Propolis Component Helps in Radiation Treatment

CAPE Sensitizes CT26 Colorectal Adenocarcinoma to IR, Does Not Affect Marrow Radioresponse, Biotech Week, 12/21/05

Caffeic acid phenethyl ester preferentially sensitizes CT26 colorectal adenocarcinoma to ionizing radiation without affecting bone marrow radioresponse.

According to a study from Taiwan, "Caffeic acid phenethyl ester (CAPE), a component of propolis, was reported capable of depleting glutathione (GSH). We subsequently examined the radiosensitizing effect of CAPE and its toxicity. The effects of CAPE on GSH level, GSH metabolism enzyme activities, NF-kappa B activity, and radiosensitivity in mouse CT26 colorectal adenocarcinoma cells were determined."

Y.J. Chen and colleagues at the Taipei Veterans General Hospital explained, "BALB/c mouse with CT26 cells implantation was used as a syngeneic in vivo model for evaluation of treatment and toxicity end points. CAPE entered CT26 cells rapidly and depleted intracellular GSH in CT26 cells, but not in bone marrow cells. . ."

Chen and colleagues published the results of their research in International Journal of Radiation Oncology, Biology, & Physics (Caffeic acid phenethyl ester preferentially sensitizes CT26 colorectal adenocarcinoma to ionizing radiation without affecting bone marrow radioresponse. Int J Radiat Oncol Biol Phys, 2005;63(4):1252-1261).

For additional information, contact M.S. Shiao, Taipei Veterans General Hospital, Dept. of Medical Research & Education, 201 Shih Pai Rd., Section 2, Taipei 11217, Taiwan.

The publisher of the International Journal of Radiation Oncology, Biology, & Physics can be contacted at: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-1710, USA.