Up to 6.6% of Patients Are Sensitive to Propolis

Allergic Contact Dermatitis from Propolis
Susan E. Walgrave; Erin M. Warshaw; Lynn A. Glesne, Dermatitis, 1/19/2006

Abstract: Propolis is commonly used in cosmetic and medicinal preparations because of its antiseptic, antiinflammatory, and anesthetic properties. Its therapeutic qualities have been well documented. However, 1.2 to 6.6% of patients who are patch-tested for dermatitis are sensitive to propolis. The main allergens are 3-methyl-2-butenyl caffeate and phenylethyl caffeate. Benzyl salicylate and benzyl cinnamate are less frequent sensitizers. Propolis is found in a number of "natural" products, including lip balms, cosmetics, lotions and ointments, shampoos, conditioners, and toothpastes. Dermatologists should consider patch testing with propolis in users of such remedies.

Also in this article:

* Composition of Propolis
* Responsible Allergens
* Potential Medical Uses and Biologic Properties of Propolis
* Type IV Contact Dermatitis Reactions to Propolis
* Type I Immunoglobulin E–Mediated Reactions to Propolis
* Reactions to Ingested Propolis
* Patch Testing
* Summary