Possible Mechanism for Sustained Release of Bee Venom

Sustained Release of Bee Venom Peptide from Biodegradable Thermosensitive PLGA-PEG-PLGA Triblock Copolymer-Based Hydrogels in Vitro
Die Pharmazie, 2006 Mar;61(3):199-202

The release of bee venom peptide from the copolymer-based hydrogel and hydrogel degradation in the phosphate buffer (pH 7.4) was studied at 37 degrees C under agitation. Bee venom peptide was released from the copolymer-based hydrogels over 40 days in vitro and the variation of DL-lactide/glycolide molar ratio in the PLGA block of the copolymer did not significantly affect the release rate of bee venom peptide (P > 0.05)…

These results indicate that the PLGA-PEG-PLGA copolymer-based hydrogel could be a promising platform for sustained delivery of bee venom peptide.