Research From Kobe University, Japan Provides New Insights Into Human HealthLab Business Week, 11/12/2006
Administration of Artepillin C may prevent colon cancer.
According to a study from Japan, "Potential chemopreventive agents exist in foods. Artepillin C in Brazilian propolis was investigated for its effects on colon carcinogenesis."
"We had found that artepillin C was a bioavailable antioxidant, which could be incorporated into intestinal Caco-2 and hepatic HepG2 cells without any conjugation and inhibited the oxidation of intracellular DNA…
The researchers concluded, "Artepillin C appears to prevent colon cancer through the induction of cell-cycle arrest by stimulating the expression of Cip1/p21 and to be a useful chemopreventing factor in colon carcinogenesis."
Shimizu and colleagues published the results of their research in Molecular Carcinogenesis (Artepillin C in Brazilian propolis induces G(0)/G(1) arrest via stimulation of Cip1/p21 expression in human colon cancer cells. Mol Carcinog, 2005;44(4):293-299).
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