Propolis Stimulates Development of Blood Cells

Hematostimulative Action of Water - Soluble Derivative of Propolis (WSDP)

Oršolić N, Tadić Z, Benković V, Horvat Knežević A, Ličić D, Đikić D, Bašić I.Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000 Zagreb, Croatia

Presented at: 5th German Apitherapy Congress, March 23-25, 2007, Passau, Germany

Summary: We have investigated the effect of a water - soluble derivative of propolis (WSDP) on hematopoiesis of CBA mice using exogenous spleen colony assay (CFUs assay). Given perorally (p.o.) 50 mg/kg to mice for 20 consecutive days WSDP increased the number of exogenous C.F.U.s as compared to control. WSDP given either for 20 or 40 days elevated the number of cells in hematopoietic tissue and increased the number of leucocytes in peripheral blood; prolonged treatment with WSDP also elevated histological appearance of myeloid and megakaryocytic types of C.F.U.s. These studies encourage further investigations on the mode of the radioprotective action of WSDP and its use not only in research concerning hematopoiesis, but also in studies related to its use in combined therapy with radiation and/or cytotoxic drugs.