Propolis Component May Stimulate Glucose Metabolism

CAPE (caffeic acid phenethyl ester) Stimulates Glucose Uptake Through AMPK (AMP-activated protein kinase) Activation in Skeletal Muscle Cells
Biochemical and Biophysical Research Communications, July 24, 2007

Abstract: Caffeic acid phenethyl ester (CAPE), a flavonoid-like compound, is one of the major components of honeybee propolis.

In the present study, we investigated the metabolic effects of CAPE in skeletal muscle cells and found that CAPE stimulated glucose uptake in differentiated L6 rat myoblast cells and also activated AMPK (AMP-activated protein kinase)…

In summary, our results suggest that CAPE may have beneficial roles in glucose metabolism via stimulation of the AMPK pathway.