Antibacterial Activity of Propolis Against MRSA and Synergism with Topical MupirocinThe Journal of Alternative and Complementary Medicine, 2007, 13(7): 713-718.
Objectives: The aim of the present study was to investigate the activity of the propolis and its combinations with mupirocin against methicillin-resistant Staphylococcus aureus (MRSA) in nasal carriage.
Methods: This study was carried out between June and August 2005. To infect nares of the rabbits, MRSA (ATCC 33591) strain was used. Minimum inhibitory concentration was determined according to National Committee for Clinical Laboratory Standards…
Results: The colony numbers of bacteria in group 1 were determined to be significantly lower than in group 2 (p = 0.0001), group 3 (p = 0.0001), and group 4 (p = 0.0001). The mean bacterial cell counts of groups 1–4 were 360.2 ± 52.4 cfu/mL, 4120.6 ± 860.4 cfu/mL, 5980.8 ± 1240.6 cfu/mL, and 11500.0 ± 2568.4 cfu/mL, respectively. Mupirocin + propolis administration (group 1) resulted in a significant reduction in the polymorphonuclear leukocyte (PMNL) count in the mucous membranes of rabbits compared with the other treatment groups (p
Conclusions: Propolis addition to mupirocin regimen was found to result in more profound reduction in bacterial cell count and inflammatory response compared with the rest of the treatment modalities.
Mupirocin antibiotic used to treat impetigo as well as protect from other skin infections caused by bacteria. It is not effective against fungal or viral infections.This medication is sometimes prescribed for other uses.
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