Propolis Component as Effective as Steroid in Reducing Eye Inflammation

Effect of Caffeic Acid Phenethyl Ester on Treatment of Experimentally Induced Methicillin-Resstant Staphylococcus Epidermidis Endophthalmitis in a Rabbit Model
Cell Biochemistry and Function, Volume 25, Issue 6 , Pages 693 - 700

Abstract: This study investigated the anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a natural bee-produced compound, and compared it with corticosteroids in the treatment of experimentally induced methicillin-resistant Staphylococcus epidermidis (MRSE) endophthalmitis in addition to intravitreal antibiotics…

There were no statististically significant differences between clinical scores of all groups in examinations at 24 and 48 h post-infection (p = 0.915 and p = 0.067 respectively), but in examinations at 72 h post-infection and after 7 days post-infection, although the clinical scores of treatment groups were not significantly different from each other, they were significantly lower than the control group (p < 0.05).

The culture results of all groups were sterile. As a result, CAPE was found to be as effective as dexamethasone in reducing inflammation in the treatment of experimental MRSE endophthalmitis when used with antibiotics. More studies are needed to determine the optimal administration route and effective dosage of this compound.