Anti-Recombinogenic Effect of Propolis is Dose-Dependent

Inhibitory Effects of Water Extract of Propolis on Doxorubicin-Induced Somatic Mutation and Recombination in Drosophila Melanogaster
Food and Chemical Toxicology, Article in Press, Corrected Proof

Abstract: Propolis is a substance produced by honeybees (Apis mellifera L.). Its components are strong antioxidants and free radical scavengers.

The aim of this study was to evaluate the protective effects of a water extract of Brazilian green propolis (WEP) combined with the antitumor agent doxorubicin (DXR) on Drosophila melanogaster wing cells through the somatic mutation and recombination test (SMART)…

The results obtained with the two different crosses were rather similar. Neither toxicity nor genotoxicity were observed in WEP treated series. Simultaneous treatment with different concentrations of WEP and DXR led to a reduction in the frequency of recombination compared to the treatment with DXR alone.

This anti-recombinogenic effect was proportional to the concentrations applied, indicating a dose–response correlation and can be attributed to the powerful scavenger ability of WEP.