The Effects of Bee (Apis Mellifera) Venom Phospholipase A2 on Trypanosoma Brucei Brucei and EnterobacteriaExperimental Parasitology, Article in Press
Abstract: The potential role of phospholipases in trypanosomiasis was investigated using bee venom phospholipase A2 (bvPLA2) as a model…
Even very low concentrations of bvPLA2 (10−12 mg ml−1) had some trypanocidal activity. Bee venom PLA2 was bactericidal to 2 h bacterial cultures but bacteriostatic to 12 h ones. Minimum bactericidal concentrations were 10−5–10−6 mg ml−1.
The results showed that bvPLA2 had significant trypanocidal and antibacterial effects on Gram-negative bacteria. The relationship to events occurring during infection is discussed. Phospholipases may play a role in increased endotoxin levels in trypanosomiasis.
No comments:
Post a Comment