Effect of NFκB Inhibition by CAPE on Skeletal Muscle Ischemia-Reperfusion InjuryJournal of Surgical Research, 12 May 2008
Background/Aims: Nuclear factor κ B (NFκB) plays important role in the pathogenesis of skeletal muscle ischemia/reperfusion (I/R) injury. Caffeic acid phenyl ester (CAPE), a potent NFκB inhibitor, exhibits protective effects on I/R injury in some tissues. In this report, the effect of CAPE on skeletal muscle I/R injury in rats was studied…
Results: Animals submitted to ischemia showed a marked increase in aminotransferases after reperfusion, but with lower levels in the CAPE group. Tissue glutathione levels declined gradually during ischemia to reperfusion, and were partially recovered with CAPE treatment. The histological damage score, muscle edema percentage, tissue malondialdehyde content, apoptosis index, and neutrophil and mast cell infiltration, as well as 4HNE and NFκB p65 labeling, were higher in animals submitted to I/R compared with the ischemia group. However, the CAPE treatment significantly reduced all of these alterations.
Conclusions: CAPE was able to protect skeletal muscle against I/R injury in rats. This effect may be associated with the inhibition of the NFκB signaling pathway and decrease of the tissue inflammatory response following skeletal muscle I/R.
See: Pinocembrin Protects Rat Brain Against Oxidation and Apoptosis Induced by Ischemia–Reperfusion Both In Vivo and In Vitro
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