Antiviral Activity of Propolis Against Some Avian VirusesA. G. Hegazi1, F. K. Abd El Hady and A.A. Faraghli, Departments of Zoonotic Diseases and Chemistry of Natural Products, National Research Center, Dokki, Giza, Egypt. Animal Health Research Institute, Dokki, Giza, Egypt. E- mail: ahmedgaffer@mailer.eun.eg and amedhegazi128@mail.com
[Presented at APIMEDICA and APIQUALITY 2008 in Rome.]
Three Egyptian propolis samples were collected from Dakahlia, Ismailia and Sharkia provinces. The antiviral activity of propolis samples was investigated against some avian viruses as infectious bursal disease virus (IBDV), reovirus (RV), infectious bronchitis virus (IBV), larngotracheitis virus (LTV) and Newcastle disease virus (NDV). All propolis samples showed antiviral activity. It was obvious that Dakahlia propolis showed the highest antiviral activity against IB virus and LTV. While Ismailia propolis had the highest antiviral activity against IBDV and RV. On the other hand, Sharkia propolis showed the highest antiviral activity against NDV.
The influence of administration of Egyptian propolis on chicken infected with virulent Newcastle disease virus was investigated. The mortality rate of chickens was reduced in NDV infected group which was subsequently treated with propolis. Infection with vvNDV induced a significant reduction of chicken body weight. Propolis induced a significant increase in antibody titer against NDV in the infected group which was subsequently treated with propolis.
The chemical composition of propolis samples were investigated by GC/MS, 103 compounds were identified, 20 being new for propolis Dakahlia propolis was a typical poplar propolis but it contained two new caffeate esters and two new triterpenoids. Ismailia propolis was characterized by the presence of new triterpenic acid methyl esters and it did not contain any aromatic acids, esters and flavonoids.Sharkia propolis was characterized by the presence of caffeate esters only, some di- and triterpenoids.
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