Propolis Has Immunomodulatory Effect

Immunomodulatory Action of Propolis: VII. A Comparative Study on Cinnamic and Caffeic Acid Lysine Derivatives
Comptes Rendus de l'Academíe Bulgare des Sciences
Ivanovska, N., Stefanova, Z., Valeva, V., Neychev, H.
Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

Lysine derivatives of two components of propolis, cinnamic acid and caffeic acid, were prepared (acid to lysine ratio 2:1), and their effects on residual alternative pathway (AP) and C3 activities were determined.

AP haemolysis was strongly inhibited by both compounds and C3 activity by the derivative of cinnamic acid, whereas that of caffeic acid had less effect. Further studies on the probable mechanisms involved, including in vivo tests using mice, are described.