Gelam Honey Inhibits Lipopolysaccharide-Induced Endotoxemia in
Rats Through the Induction of Heme Oxygenase-1 and the Inhibition of Cytokines,
Nitric Oxide, and High-Mobility Group Protein 1
Fitoterapia, 2012 May 22
Malaysian Gelam honey has anti-inflammatory and
antibacterial properties, a high antioxidant capacity, and free
radical-scavenging activity. Lipopolysaccharide (LPS) stimulates immune cells
to sequentially release early pro- and anti-inflammatory cytokines and induces
the synthesis of several related enzymes.
The aim of this study was to investigate the effect of the
intravenous injection of honey in rats with LPS-induced endotoxemia.
The results showed that after 4h of treatment, honey reduced
cytokine (tumor necrosis factor-α, interleukins 1β, and 10) and NO levels and
increased heme oxygenase-1 levels. After 24h, a decrease in cytokines and NO
and an increase in HO-1 were seen in all groups, whereas a reduction in HMGB1
occurred only in the honey-treated groups.
These results support the further examination of honey as a
natural compound for the treatment of a wide range of inflammatory diseases.
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