Caffeic Acid Phenethyl Ester Attenuates IgE-Induced
Immediate Allergic Reaction
Inflammopharmacology, 2012 May 19
Caffeic acid phenethyl ester (CAPE) is the active component
of honey bee propolis extracts. The results of the current study demonstrate
that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast
cells.
Oral administration of CAPE inhibited IgE-mediated passive
cutaneous anaphylaxis. CAPE effectively reduced both histamine and serotonin
(5-HT)-induced vascular permeability in rats. CAPE also reduced histamine and
leukotrienes (LTs) release from isolated rat peritoneal mast cells. Moreover,
CAPE suppressed contraction induced by histamine (3 × 10(-8)-3 × 10(-5) M),
5-HT (3 × 10(-9)-10(-6) M) and adenosine (3 × 10(-8)-10(-5) M) in guinea pig
tracheal zigzag.
These findings provide evidence that CAPE may serve as an
effective therapeutic agent for allergic diseases.
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