Neuro-Protective Effects of Bee Venom by Suppression of Neuroinflammatory
Responses in a Mouse Model of Parkinson's Disease: Role of Regulatory T Cells
Brain Behav Immun, 2012 Sep 5
In the present study, we sought to determine whether bee
venom (BV) promotes the survival of dopaminergic (DA) neurons in the
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's
disease (PD).
Treatment with BV prevented degeneration of DA neurons in
the substantia nigra (SN). This neuro-protective effect of BV was associated
with microglial deactivation and reduction of CD4 T cell infiltration.
Additionally, BV treatment significantly increased the proportion of
CD4(+)CD25(+)Foxp3(+) Tregs in vivo and in vitro. The increased proportion of
Tregs by BV treatment remained suppressive activity ex vivo. Interestingly, BV
treatment did not prevent MPTP neurotoxicity in mice depleted of Tregs by anti-CD25
antibody injection.
Therefore, our present studies suggest that modulation of
peripheral immune tolerance by Treg may contribute to the neuroprotective
effect of BV in the MPTP model of Parkinson's disease.
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