Anti-Inflammatory Activity of a Honey Flavonoid Extract on Lipopolysaccharide-Activated
N13 Microglial Cells
J Agric Food Chem, 2012 Nov 26. [Epub ahead of print]
Neuroinflammation is an important contributor to
pathogenesis of age-related neurodegenerative disorders as Alzheimer or
Parkinson´s disease. Accumulating evidence indicates that inhibition of
microglia-mediated neuroinflammation may become a reliable protective strategy
for neurodegenerative processes. Flavonoids, widely distributed in the
vegetable kingdom and in aliments like honey have been suggested as novel
therapeutic agents for the reduction of the deleterious effects of
neuroinflammation. In the present study, we investigated the potential
protective effect of a honey flavonoid extract (HFE) on the production of
proinflammatory mediators by lipopolysaccharide-stimulated N13 microglia. Our
results show that HFE significantly inhibited the release of the
proinflammatory cytokines as TNF-alpha and IL-1beta. The expressions of iNOS
and the production of ROS were also significantly inhibited.
Accordingly, present study demonstrates that HFE is a potent
inhibitor of microglial activation and thus a potential preventive-therapeutic
agent for neurodegenerative diseases involving neuroinflammation.
No comments:
Post a Comment