Effect of Royal Jelly on Spatial Learning and Memory in Rat
Model of Streptozotocin-Induced Sporadic Alzheimer's Disease
Adv Biomed Res, 2012;1:26
BACKGROUND:
It has been recently demonstrated that Royal jelly (RJ) has
a beneficial role on neural functions. Alzheimer's disease (AD) is associated
with impairments of learning and memory. Therefore, the present study was
designed to examine the effect of RJ on spatial learning and memory in rats
after intracerebroventricular injection of streptozotocin (icv-STZ).
MATERIALS AND METHODS:
Rats were infused bilaterally with an icv injection of STZ,
while sham rats received vehicle only. The rats were feed with RJ-contained
food (3% w/w) (lyophilized RJ mixed with powdered regular food) or regular food
for 10 days. Then spatial learning and memory was tested in the rats by Morris water
maze test.
RESULTS:
Results showed that in icv-STZ group latency and path length
were increased as compared to sham group, also icv-STZ rats less remembered the
target quadrant that previously the platform was located; however, these were
protected significantly in STZ group that received RJ-containing food.
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