J Arthropod Borne Dis, 2012 Dec;6(2):136-43
BACKGROUND:
Diabetes is an important disease. This disease is a
metabolic disorder characterized by hyperglycemia resulting from perturbation
in insulin secretion, insulin action or both. Honey bee venom contains a wide
range of polypeptide agents. The principle components of bee venom are mellitin
and phospholipase A(2). These components increase insulin secretion from the
β-cells of pancreas. This study was conducted to show the hypoglycemic effect
of honey bee venom on alloxan induced diabetic male rats.
METHODS:
Eighteen adult male rats weighting 200±20 g were placed into
3 randomly groups: control, alloxan monohydrate-induced diabetic rat and
treated group that received honey bee venom daily before their nutrition for
four months. Forty eight hours after the last injection, blood was collected
from their heart, serum was dissented and blood glucose, insulin, triglyceride
and total cholesterol were determined.
RESULTS:
Glucose serum, triglyceride and total cholesterol level in
treated group in comparison with diabetic group was significantly decreased (P <
0.01). On the other hand, using bee venom causes increase in insulin serum in
comparison with diabetic group (P < 0.05).
CONCLUSION:
Honeybee venom (apitoxin) can be used as therapeutic option
to lower blood glucose and lipids in diabetic rats.
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