Toxicology, April 2013
The present work aimed to study the toxic effect of cadmium
(Cd) on rabbits’ blood indices, as well as the therapeutic effect of the
antioxidant agents, vitamins C and B complex and bee honey on Cd intoxicated
rabbits.
Cadmium chloride (CdCl2) was injected subcutaneously at a
dose of 3 mg/kg of body weight. The results showed a significant increase in serum
glucose, triglycerides, cholesterol, total protein, albumin, globulin, urea and
creatinine, compared to the control group. In addition, CdCl2 intoxication
increased the levels of uric acid, aspartate aminotransferase, alanine
aminotransferase, alkaline phosphatase and bilirubin. Concerning haematological
parameters, the more obvious changes were an increase in mean corpuscular
volume and a decrease in white blood cells count, platelets, lymphocytes,
heamatocrit, haemoglobin and red blood cells count.
Treatment of CdCl2-intoxicated animals with vitamins C and B
complex and bee honey showed a decrease in the harmful effects of Cd by
restoring haematological and biochemical changes. Bee honey treatment was the
most effective in providing recoveries in the altered blood parameters.
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