J. Agric. Food Chem, Article ASAP
The objective of this study was to evaluate
anti-inflammatory and antimicrobial activities of neovestitol and vestitol
isolated from Brazilian red propolis (BRP).
BRP ethanolic extract (EEP), neovestitol, and vestitol were
evaluated by anti-inflammatory properties using a neutrophil migration assay.
The antimicrobial activity was evaluated by minimal inhibitory and bactericidal
concentrations (MIC and MBC) against Streptococcus mutans, Streptococcus
sobrinus, Staphylococcus aureus, and Actinomyces naeslundii. Neovestitol,
vestitol, and EEP inhibited neutrophil migration at a dose of 10 mg/kg.
Regarding antimicrobial activity, neovestitol showed MICs ranging from < 6.25
to 25–50 μg/mL and MBCs ranging from 25–50 to 50–100 μg/mL, while vestitol
showed MICs ranging from 25–50 to 50–100 μg/mL and MBCs ranging from 25–50 to
50–100 μg/mL.
Both isoflavonoids neovestitol and vestitol are consistent
bioactive compounds displaying anti-inflammatory and antimicrobial activities
that can strongly act in a low dose and concentration and have a promising
potential to be applied in the pharmaceutical and food industries.
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