J BUON, 2013 Apr-Jun;18(2):504-10
Purpose: Natural products have been investigated for
promising new leads in pharmaceutical development. The purpose of this study
was to analyze the biological effect of GE132+Natural, a novel supplement
consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane,
Lycopene and Royal jelly.
Methods: The antiproliferative activity of GE132+Natural was
tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3
(prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy
926 (normal human endothelial cell line). In addition, the cytotoxicity of
GE132+- Natural on the proliferation of primary human mesenchymal stem cells
isolated from dental pulp (DP=MSC), along with its in vitro impact on different
peripheral blood parameters, was determined.
Results: The results revealed high antiproliferative
activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and
SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent
manner. However, applied in a wide range of concentrations GE132+Natural did
not affect both the proliferation of primary mesenchymal stem cells and the
peripheral blood cells counts.
Conclusion: The data obtained demonstrated that
GE132+Natural is effective in inhibiting cancer cell proliferation, indicating
its potential beneficial health effects. In addition, the results pointed that
adult mesenchymal stem cells might be valuable as a test system for evaluating
the toxicity and efficacy of new medicines or chemicals.
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