The protective effect of natural bees' honey to the liver of
male albino rats against melamine toxicity was studied. Melamine
supplementation at a dose of 20000 ppm in the diet for 28 days induced adverse
effects on the liver, decreased serum total protein and increased liver enzyme:
alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase.
Histological changes of the melamine supplemented group showed necrosis in the
hepatic tissues around the central veins of the liver and precipitation of
melamine crystals. Treating the male albino rats (that were presupplemented
regularly with 20000 ppm melamine) with natural bees' honey at a dose of
2.5 g/kg body weight for 28 days improved both liver functions and increased
serum protein. In addition, a positive impact on the shape of the cells after
treatment with honey compared to the positive melamine supplemented group was
observed. In conclusion, the results of this study revealed that the use of
natural bees' honey has the ability to protect the liver of rats against the
toxic effects of melamine.
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