J Enzyme Inhib Med Chem, 2013 Oct 24
Abstract Monoamine oxidase (MAO) inhibitors are generally
used in the treatment of depressive disorders and some neurodegenerative
illnesses, such as Parkinson's disease and Alzheimer's disease.
The aim of this preliminary study was to investigate the MAO
[MAO (E.C.1.4.3.4)] inhibiting effect of various apitherapeutic products, such
as chestnut honey, pollen and propolis.
Extracts' MAO inhibition was measured using
peroxidase-linked spectrophotometric assay in enzyme isolated from rat liver
microsomes, and the values are expressed as the inhibition concentration (IC50)
causing 50% inhibition of MAO. The antioxidant activity of the bee products was
also determined in terms of total phenolic content (TPC) and ferric
reducing/antioxidant power in aquatic extracts.
All samples exhibited substantial inhibition of MAO,
propolis having the highest. Inhibition was related to samples' TPCs and
antioxidant capacities.
These results show that bee products possess a sedative
effect and may be effective in protecting humans against depression and similar
diseases.
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