Acute administration of natural honey protects isolated
heart in normothermic ischemia
Iran J Pharm Res. 2012 Fall;11(4):1275-84.
This study intended to assess the efficacy of acute
administration of natural honey on cardiac arrhythmias and infarct size when it
is used during the normothermic ischemia in isolated rat heart.
During 30 min of regional normothermic ischemia followed by
120 min of reperfusion, the isolated hearts were perfused by a modified drug
free Krebs-Henseleit solution (control) or the solution containing 0.125, 0.25,
0.5 and 1% of freshly prepared natural honey (test groups), respectively.
Cardiac arrhythmias were analyzed and determined through the recorded ECGs. The
infarct size was measured using computerized planimetry package.
At the ischemic phase, honey (0.25 and 0.5%) decreased the
number and duration of ventricular tachycardia (VT), total number of
ventricular ectopic beats (VEBs), duration and incidence of reversible
ventricular fibrillation (VF) and total VF (p < 0.05 for all). During the
reperfusion, concentrations of 0.125, 0.25 and 0.5% lowered the number of VT (p
< 0.05), duration of reversible VF (p < 0.01) and total number of VEBs (p
< 0.05). In addition, VT duration was reduced significantly with honey 0.125
and 0.25%. Moreover, the infarct size was 45.6 ± 3.4% in the control group,
while the perfusion of honey (0.125, 0.25 and 0.5%) reduced it to 14.8 ± 5.1 (p
< 0.001), 24.6 ± 7.3 (p < 0.01) and 31.4 ± 7.3% (p < 0.05), respectively.
Regarding the results, it is concluded that the acute
administration of natural honey in normothermic ischemia conditions can protect
the rat heart as the reduction of infarct size and arrhythmias. Conceivably,
the antioxidant and free radical scavenging activity, the reduction of
necrotized tissue and the providence of rich energy source are more important
mechanisms in cardioprotective effects of natural honey.
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