Chemical composition, antioxidant and anti-AGEs activities of
a French poplar type propolis
J Agric Food Chem, 2014 Jan 20
Accumulation in tissues and serum of advanced glycation
end-products (AGEs) plays an important role in pathologies such as Alzheimer's
disease or, in the event of complications of diabetes, atherosclerosis or renal
failure. Therefore there is a potential therapeutic interest in compounds able
to lower intra and extracellular levels of AGEs. Among them, natural
antioxidants (AO) with true anti-AGEs capabilities would represent good
candidates for development.
The purpose of this study was to evaluate the AO and
anti-AGEs potential of a propolis batch, then to identify the main compounds
responsible for these effects. In vivo, protein glycation and oxidative stress
are closely related. Thus AO and antiglycation activities were respectively
evaluated using both DPPH and ORAC assays as well as a newly developed
automated anti-AGEs test.
Several propolis extracts exhibited very good AO and
anti-AGEs activities and a bio-guided fractionation allowed us to identify
pinobanksin-3-acetate as the most active component.
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