Volume 20, Issue 2, 25 March 2014, Pages 499–504
Atopic dermatitis (AD) is a chronic inflammatory skin disease that was influenced by complex interactions via genetic, environmental, immunologic, and biochemical factors, though the cause of AD is still unknown. It characterized by elevated serum immunoglobulin E (IgE) levels, immunological abnormalities, and eosinophilia in the tissues and peripheral blood. In the present study, we applied an antimicrobial moisturizing cream containing low-molecular weight water-soluble chitosan and herbal honey (AMCH) to remedy AD-like lesions.
Atopic dermatitis (AD) is a chronic inflammatory skin disease that was influenced by complex interactions via genetic, environmental, immunologic, and biochemical factors, though the cause of AD is still unknown. It characterized by elevated serum immunoglobulin E (IgE) levels, immunological abnormalities, and eosinophilia in the tissues and peripheral blood. In the present study, we applied an antimicrobial moisturizing cream containing low-molecular weight water-soluble chitosan and herbal honey (AMCH) to remedy AD-like lesions.
The inhibiting effect of AMCH on NC/Nga mice, that AD-like
lesion was induced by 1-chloro-2,4-dinitrobenzene (DNCB), was evaluated by
examining sensory evaluation scores, scratching behavior, immune cells in
blood, serum IgE level, infiltration of mast cells, and skin histology. The
total sensory evaluation scores, scratching behavior, the level of serum IgE,
interlukin-4 (IL-4), and IL-12 in AD mouse model were significantly reduced by
AMCH. Moreover, its suppressing effect resulted in decreased mast cell infiltration.
Our results suggest that AMCH might be beneficial as a potent agent for
treatment of AD-like lesion.
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