Topical Anti-Inflammatory Activity of a Monofloral Honey of
Mimosa scabrella Provided by Melipona marginata During Winter in Southern
Brazil
J Med Food, 2014 Mar 20
Melipona marginata is an endangered species of stingless bee
from Brazil that produces honey with particular physicochemical features and a
remarkable exotic flavor. To the best of our knowledge, this is the first
report devoted to exploring the medicinal potential of this honey. Thus, the
aim of this paper was to investigate the potential anti-inflammatory activity
of honey extract from M. marginata on skin inflammation.
The honey sample was classified as a monofloral honey of
Mimosa scabrella. The presence of 11 phenolic compounds as kaempferol and
caffeic acid was detected using the high-performance liquid
chromatography-electrospray ionization-tandem mass spectrometry
(HPLC-UV-ESI-MS) method. The anti-inflammatory activity was measured using a
12-O-tetradecanoylphorbol-13-acetate-induced ear edema model of inflammation in
mice. The topical application of the M. marginata honey extract (1.0 mg/ear)
was able to reduce ear edema with an inhibitory effect of 54±5%. This extract
decreased the myeloperoxidase activity in 75±3%, which suggests a lower
leucocyte infiltration that was confirmed by histological analysis. This
extract also provided a reduction of 55±14% in the production of reactive oxygen
species. This anti-inflammatory activity could be due to a synergic effect of
the phenolic compounds identified in the honey sample.
Taken together, these results open up new possibilities for
the use of M. marginata honey extract in skin disorders.
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