Propolis Modulates Fibronectin Expression in the Matrix of
Thermal Injury
Volume 2014 (2014), Article ID 748101, 10 pages
The aim of the study was to assess the propolis effect on
fibronectin metabolism in the course of burn wounds healing process. A model of
burn wound healing of pig skin was applied. The amount of the released
glycoprotein was assessed by a surface plasmon resonance. The profile of
extracted fibronectin components was also assessed by an electrophoresis in
polyacrylamide gel, with a subsequent immunodetection by Western Blotting.
Propolis burn treatment decreased the release of fibronectin components from healing
wounds in relation to damages treated with silver sulfadiazine. The main reason
of decreased extraction of fibronectin components from wounds treated with
propolis was a substantial decrease of degradation product release of the
mentioned glycoprotein, which was observed particularly from the 3rd to 5th day
of the repair.
Wounds treatment with propolis demonstrated, especially in
relation to damages treated with silver sulfadiazine, the decreased release of
synthesized fibronectin molecules. The obtained results suggest that propolis
modifies fibronectin metabolism in the course of wound healing process. The
influence of propolis is reflected in prevention of fibronectin biosynthesis as
well as its degradation in the wound area. The above-mentioned metabolic
changes may decrease the risk of complications in the repair wounds process.
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