Effects of stingless bee propolis on experimental asthma
Evid Based Complement Alternat Med, 2014;2014:951478
Bee products have been used empirically for centuries,
especially for the treatment of respiratory diseases. The present study
evaluated the effect of treatment with a propolis hydroalcoholic extract (PHE)
produced by Scaptotrigona aff. postica stingless bee in a murine asthma model.
BALB/c mice were immunized twice with ovalbumin (OVA)
subcutaneously. After 14 days, they were intranasally challenged with OVA.
Groups P50 and P200 received PHE by gavage at doses of 50 and 200 mg/kg,
respectively. The DEXA group was treated with intraperitoneal injection of
dexamethasone. The OVA group received only water. The mice were treated daily
for two weeks and then they were immunized a second time with intranasal OVA.
The treatment with PHE decreased the cell number in the
bronchoalveolar fluid (BAL). Histological analysis showed reduced
peribronchovascular inflammation after treatment with PHE especially the
infiltration of polymorphonuclear cells. In addition, the concentration of
interferon- γ (IFN- γ ) in the serum was decreased. These results were similar
to those obtained with dexamethasone.
Treatment with S. aff postica propolis reduced the pathology
associated with murine asthma due an inhibition of inflammatory cells migration
to the alveolar space and the systemic progression of the allergic
inflammation.
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