Propolis cinnamic acid derivatives induce apoptosis through
both extrinsic and intrinsic apoptosis signaling pathways and modulate of miRNA
expression
Volume 21, Issues 8–9, July–August 2014, Pages 1070–1077
Propolis cinnamic acid derivatives have a number of
biological activities including anti-oxidant and anti-cancer ones. In this
study, we aimed to elucidate the mechanism of the anti-cancer activity of 3
representative propolis cinnamic acid derivatives, i.e., Artepilin C, Baccharin
and Drupanin in human colon cancer cell lines. Our study demonstrated that
these compounds had a potent apoptosis-inductive effect even on drug-resistant
colon cancer cells. Combination treatment of human colon cancer DLD-1 cells
with 2 of these compounds, each at its IC20 concentration, induced apoptosis by
stimulating both intrinsic and extrinsic apoptosis signaling pathways.
Especially, Baccharin plus Drupanin exhibited a synergistic growth-inhibitory
effect by strengthening both intrinsic and extrinsic apoptotic signaling
transduction through TRAIL/DR4/5 and/or FasL/Fas death-signaling loops and by
increasing the expression level of miR-143, resulting in decreased expression
levels of the target gene MAPK/Erk5 and its downstream target c-Myc.
These data
suggest that the supplemental intake of these compounds found in propolis has
enormous significance with respect to cancer prevention.
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