A Review on Antiproliferative and Apoptotic Activities of
Natural Honey
Anticancer Agents Med Chem, 2014 Jul 21
Recent statistics revealed cancer is one among the main
reasons for death throughout the world. Several treatments are available but
still there is no cure when it is detected at late stages. One of the treatment
modes for cancer is chemotherapy which utilizes anticancer drugs in order to
eradicate the cancer cells by apoptosis. Apoptosis is programmed cell death
through which body maintains homeostasis or kills cancer cells by utilizing its
cell machinery. Recent researches have concluded that dietary agents have a
putative role in instituting apoptosis of cancer cells. Honey, one of the
victuals rich in antioxidants, has a long-standing exposure to humans and its
role in cancer prevention and treatment is a topic of current interest. Various
researchers have been experimenting honey against different cancers and
provided valuable insights about the apoptosis induced by the honey.
This
review will highlight the recent findings of apoptotic mechanism involved in
different cancer cells. Further it also reports antitumor activity of honey in
some animal models. Hence it is high-time to initiate more preclinical trials
as well as clinical experiments which would further add to the knowledge of
anticancer nature of honey and also endorse honey as a potential candidate in
the war against cancer.
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