J Clin Biochem Nutr. 2014 Jul;55(1):7-10
Aging weakened innate and adaptive immunity both
quantitatively and qualitatively. Some components in propolis could stimulate
immune function in young animals or cultured immune cells in vitro. Few studies
had been carried out in the aged. The present study was to evaluate the effects
of Brazilian green propolis supplementation on the immunological parameters in
aged mice.
Eighty Kunming mice, aged 15-18 months, were randomly
assigned to the control and three experimental groups supplemented with
different doses (83.3, 157.4 and 352.9 mg/kg.bw respectively) of Brazilian
green propolis. The experiment lasted for 4 weeks. Contents of total
polyphenol, flavonoid, cinnamic acid and artepillin-C in Brazilian green
propolis were analyzed. Splenic NK cytotoxic, T lymphocyte proliferation and
antibody generation cells, as well as the phagocytosis of peritoneal
macrophages, ear swelling, and serum contents of IgG, IgM, hemolysin and
cytokines were measured.
After 4 weeks of treatment, the phagocytosis of peritoneal macrophages
was enhanced in 157.4 mg/kg and 352.9 mg/kg groups. Ear swelling increased in
all propolis treatmented groups. Antibodies specific to sheep erythrocytes were
higher in the groups receiving 157.4 and 352.9 mg/kg.bw than that of control
group. IgG level dramatically increased in the groups receiving 83.3 and 157.4
mg/kg.bw in comparison to the control group.
These results indicate that administration of Brazilian
green propolis have a positive effect on innate and adaptive immunity in aged
mice.
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