Significance of propolis administration for homeostasis of
CD4+CD25+ immunoregulatory T cells controlling hyperglycemia
7th Space, 9/15/2014
In the present study,
we examined the effect of ethanolic soluble derivative of propolis (EEP)
extract on immunological function in diabetic mouse models with the aim of
highlighting the role of regulatory T cell, the change of cell surface
molecule, and in vivo productions of IFN-gamma. Murine models of diabetes
mellitus (DM) were created by injecting normal mice with S961 peptide.
Normal BALB/c mice were injected intraperitoneally with
peptide S961 300 mg/kg body weight (BW) twice a day for eight days. On day 15,
the spleen was isolated; then, cell surface molecules and regulatory T cells
were analyzed using flow cytometry…
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