Ameliorative effect of propolis against
cyclophosphamide-induced toxicity in mice
Pharm Biol, 2014 Oct 7:1-7. [Epub ahead of print]
Context: Cyclophosphamide (CTX) is a common anticancer agent
used for the treatment of several malignancies. However, upon treatment, it
induces severe toxicity due to its oxidative stress capability. Propolis, a
natural product collected by honey bees, has shown several biological
activities, such as free radical scavenging and antioxidant agent.
Objective: This study elucidates the protective effects of
propolis against CTX-induced changes in mice. Materials and methods:
Forty-eight male Swiss albino mice were divided into four groups; group 1 was
intraperitoneally (i.p.) injected with 200 µL of phosphate buffer saline (PBS),
group 2 was injected with 100 mg/kg/d propolis, group 3 was injected with a
single dose of CTX (200 mg/kg), and group 4 was injected with a single dose of
CTX (200 mg/kg) followed by propolis (100 mg/kg) for 7 consecutive days. After
12 d, mice were bled and then sacrificed to analyze the hematological,
biochemical, and histological parameters.
Results: The results indicated that CTX-injected mice showed
an increase in the levels of alanine aminotransferase (ALT), aspartate
aminotransferase (AST), urea, and creatinine and a decrease in the total number
of white blood cells (WBCs) and platelets. Moreover, dramatically changes in
the histological architectures of the liver and kidney were observed. The mice
that were injected with CTX/propolis showed an improvement in the levels of
ALT, AST, urea, creatinine, WBCs, and platelets. Moreover, the histological
picture of the liver and kidney was significantly improved.
Conclusions: In conclusion, propolis might be considered an
effective agent in ameliorating the toxicity resulted from CTX treatment.
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