Protective Effect of Sundarban Honey against
Acetaminophen-Induced Acute Hepatonephrotoxicity in Rats
Evid Based Complement Alternat Med. 2014;2014:143782
Honey, a supersaturated natural product of honey bees,
contains complex compounds with antioxidant properties and therefore has a wide
a range of applications in both traditional and modern medicine.
In the present study, the protective effects of Sundarban
honey from Bangladesh against acetaminophen- (APAP-) induced hepatotoxicity and
nephrotoxicity in experimental rats were investigated. Adult male Wistar rats
were pretreated with honey (5 g/kg) for 4 weeks, followed by the induction of
hepatotoxicity and nephrotoxicity via the oral administration of a single dose
of APAP (2 g/kg). Organ damage was confirmed by measuring the elevation of
serum alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate
transaminase (AST), total protein (TP), total bilirubin (TB), urea, creatinine,
and malondialdehyde (MDA). Histopathological alterations observed in the livers
and the kidneys further confirmed oxidative damage to these tissues.
Animals pretreated with Sundarban honey showed significantly
markedly reduced levels of all of the investigated parameters. In addition,
Sundarban honey ameliorated the altered hepatic and renal morphology in
APAP-treated rats. Overall, our findings indicate that Sundarban honey protects
against APAP-induced acute hepatic and renal damage, which could be attributed
to the honey's antioxidant properties.
No comments:
Post a Comment