Dental Abstracts
Volume 62, Issue 4, July–August 2017, Pages 237–238
The treatment for advanced stage head and neck cancer typically involves radiotherapy, chemotherapy, or their combined use (radio/chemotherapy) in addition to surgical resection.
Radio/chemotherapy is unable to distinguish between normal human cells and malignant proliferating cancer cells and kills both types of cells equally. Oral mucosal cells have a high rate of proliferation and self-renewal and can become a target for radio/chemotherapy. The resulting mucositis is manifest as pain, erythema, and ulcers, leading to patient noncompliance with treatment.
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