Inflammatory Bowel Diseases
22 January 2020
To the Editors,
Microscopic colitis is a frequent cause of nonbloody chronic watery diarrhea. The diagnosis of microscopic colitis is based upon mucosal biopsy of the colon with specific histologic features in the mucosa. There are 2 subtypes, collagenous colitis and lymphocytic colitis, based on a subepithelial collagen band and increased intraepithelial lymphocytes, respectively. Although its exact etiology is unknown, the disorder is associated with medication such as nonsteroidal anti-inflammatory drugs and proton pump inhibitors and autoimmune disorders such as celiac disease, polyarthritis, and thyroid disorders. The standard therapy for microscopic colitis consists of glucocorticosteroids, antidiarrheals, and cholestyramine. Although these treatments often cause cessation of symptoms, relapses are seen...
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