Tuesday, March 06, 2012

Honey Boosts Impact of Antibiotic on MRSA

Synergy Between Oxacillin and Manuka Honey Sensitizes Methicillin-Resistant Staphylococcus aureus to Oxacillin
Journal of Antimicrobial Chemotherapy, Advance Access

Objectives

Honey is an ancient wound remedy that has recently been introduced into modern clinical practice in developed countries. Manuka honey inhibits growth of methicillin-resistant Staphylococcus aureus (MRSA) by preventing cell division. In Gram-negative bacteria a synergistic interaction between honey and antibiotics has been suggested. We aimed to determine the effect of manuka honey on oxacillin resistance in MRSA.

Methods

Inhibition of MRSA by manuka honey and oxacillin separately and in combination was tested by disc diffusion, Etest strips, serial broth dilution, chequerboards and growth curves.

Results

Manuka honey and oxacillin interacted synergistically to inhibit MRSA. Manuka honey reversed oxacillin resistance in MRSA, and down-regulation of mecR1 was found in cells treated with manuka honey.

Conclusions

Microarray analysis showed that exposure of MRSA to inhibitory concentrations of manuka honey resulted in down-regulation of mecR1. Here we demonstrated that subinhibitory concentrations of honey in combination with oxacillin restored oxacillin susceptibility to MRSA. Other honey and antibiotic combinations must now be evaluated.

1 comment:

  1. Nice info, i think people seemed to get quite confused with the various types of manuka honey available, I found this helpful guide which explains the honey ratings.

    http://www.greenbayharvest.co.uk/shop/pages/Honey+Ratings+Explained

    ReplyDelete