Saturday, April 21, 2018

Taiwanese Green Propolis Delays Progression of Type 2 Diabetes

Taiwanese Green Propolis Ethanol Extract Delays the Progression of Type 2 Diabetes Mellitus in Rats Treated with Streptozotocin/High-Fat Diet

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Nutrients. 2018 Apr 18;10(4)

Taiwanese green propolis ethanol extract (TGPE) is produced only in Taiwan and has a different composition from other types of propolis. TGPE is known for its anti-inflammation, anti-oxidation, and anti-microbial properties, but the effects and mechanisms of TGPE in the modulation of diabetes are unclear. In this study, we investigated the effects of TGPE on type 2 diabetes mellitus (T2DM) in a streptozotocin/high-fat-diet (STZ/HFD)-induced T2DM rat model.

The results revealed that TGPE delayed the development and progression of T2DM and reduced the severity of β-cell failure. TGPE also attenuated inflammation and reactive oxygen species ROS in the rats. Moreover, there were higher levels of oxidant cytokines, leptin, and adiponectin in the serum of the TGPE-treated group. Unlike Brazilian propolis, TGPE promoted hepatic genes PPAR-α and CYP7A1, which were related to lipid catabolism and removal. TGPE may thus delay the progression of T2DM through anti-inflammation effects, anti-oxidation effects, and balancing lipid metabolism.

It is suggested that TGPE can be a potential alternative medicine for T2DM.

Friday, April 20, 2018

Propolis Might Serve as Protective Agent Against Post-Surgical Adhesive Complications

Evaluation of the effects of Iranian propolis on the severity of post operational-induced peritoneal adhesion in rats

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Biomed Pharmacother. 2018 Mar;99:346-353


Peritoneal adhesion is a major complication of surgery that can lead to serious problems such as bowel obstruction, pain, infertility and even mortality. Propolis is a honey bee product with anti-inflammatory and anti-oxidant activities that could potentially protect against adhesive surgical complications.


Forty 8-weeks-old rats (275 ± 25 g) were divided into five groups: normal group without any surgical procedure, and experimental groups treated with normal saline, 50 mg/kg, 100 mg/kg and 200 mg/kg of propolis. Peritoneal adhesions were examined macroscopically and also, the levels of inflammatory factors (IL-6, IL-1β and TNF-α), growth factors (TGF-β1 and VEGF) were evaluated in the study groups using ELISA. Biochemical indices of oxidative status including Nitric Oxide (NO), Malondialdehyde (MDA) and Glutathione (GSH) were also measured.


Peritoneal adhesion scores, IL-1β, IL-6, TNF-α, TGF-β1, VEGF, NO, GSH and MDA levels were significantly different between the study groups (p < 0.001). Propolis treatment reduced peritoneal adhesion (p < 0.001), TNF-α (p < 0.001), IL-1β (p < 0.001), IL-6 (p < 0.001), TGF-β1 (p < 0.001), VEGF (p < 0.001), NO (p < 0.001) and MDA (p < 0.001), while GSH levels were increased (p < 0.001) compared with the vehicle group. Our results showed that higher dose of propolis was associated with significantly greater reductions in peritoneal adhesion (p < 0.001), TNF-α (p < 0.001), IL-1β (p < 0.001), IL-6 (p < 0.001), VEGF (p < 0.001), NO (p < 0.001) and MDA (p < 0.001), a greater increase in GSH levels (p < 0.001) compared with the lower dose.


Propolis treatment can dose-dependently reduce peritoneal adhesion through its anti-inflammatory, anti-angiogenic and antioxidant properties. Therefore, propolis might serve as a protective agent against post-surgical adhesive complications.

Thursday, April 19, 2018

Manuka Honey Helps Treat Blemishes, Acne, Burns, and Rashes

Manuka Honey, a powerful remedy for your skin woes

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Telangana Today

Bloggers and Instagrammers swear by this dark honey and use it for their skin, teeth and for minor illnesses. And with summer playing havoc with our skin, this particular honey straight from the forests of New Zealand is a perfect foil for blemishes, tanning, burns and rashes.

Brazilian Red Propolis may Help Treat Leishmaniasis and Chagas Disease

Antitrypanosomal, antileishmanial and cytotoxic activities of Brazilian red propolis and plant resin of Dalbergia ecastophyllum (L) Taub

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Food Chem Toxicol. 2018 Apr 14

The treatment for leishmaniasis and Chagas disease can be hard and painful, such that many patients give up on the treatment.

In order to find an alternative path for the treatment of these diseases, researchers are using natural products to fight these parasites. The aim of this study was to evaluate the antiprotozoan and cytotoxic activities of red propolis samples collected from different Brazilian states and seasons whilst searching for possible activity differences.

We also compared the red propolis results with the ones obtained for the plant resin extract collected from Dalbergia ecastophyllum trees. The hydroethanolic red propolis extracts from Pernambuco and Alagoas, and the D. ecastaphyllum resin were evaluated regarding their antileishmanial, antitrypanosomal and cytotoxic activity.

All extracts showed antiprotozoan and cytotoxic activity. RP-PER showed to be more cytotoxic against protozoan parasites and fibroblast cells. All propolis extracts showed a higher cytotoxic activity when compared to resin extracts.

The propolis sample collected in Pernambuco during the rainy season killed the parasites with lower concentrations than the sample collected in the dry season. The IC50 observed against the parasites could be used without high fibroblast cell damage.

Wednesday, April 18, 2018

Propolis Boosts Tonsillectomy Wound Healing

Effect of Topical Propolis on Wound Healing Process After Tonsillectomy: Randomized Controlled Study

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Clin Exp Otorhinolaryngol


The post-tonsillectomy pain and post-tonsillectomy hemorrhage are the two main problems after tonsillectomy. The aim of this study was to investigate the beneficial effects of water soluble ethanol extract propolis on post-tonsillectomy patient.


One hundred and thirty patients who underwent tonsillectomy or adenotonsillectomy were randomly divided into the control and propolis groups, each including 65 patients. The propolis group was applied with propolis orally immediately after surgery and by gargle. The pain scores were assessed on post-tonsillectomy 0, 1st, 2nd, 3rd, and 7th-10th day using a visual analogue scale score. Postoperative wound healing was evaluated by scoring pinkish membrane of tonsillar fossae on postoperative days 3 and 7-10. The incidence of post-tonsillectomy bleeding was examined in each group.


Post-tonsillectomy pain was significantly less in propolis group compared to control group on postoperative days 3 and 7-10. Post-tonsillectomy hemorrhage was significantly less in the propolis group compared to the control group (P < 0.05). The wound healing was significantly better in the propolis group compared to the control group on postoperative day 7-10 (P = 0.002).


Applying the propolis to post-tonsillectomy wound showed beneficial effect of reducing postoperative pain, preventing hemorrhage, and accelerating of wound healing of tonsillar fossae.

Tuesday, April 17, 2018

Black Seed, Egyptian Honey Show Strong Antibacterial Effects Against Multidrug-Resistant Bacteria

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Isolation and identification of bacteria causing mastitis in small ruminants and their susceptibility to antibiotics, honey, essential oils, and plant extracts

Vet World. 2018 Mar;11(3):355-362

The present work aims to isolate and identify bacteria that cause mastitis in small ruminants and evaluates the antibacterial activity of some antibiotics, honey, essential oils, and plant extracts.

Materials and Methods:

A total of 289 milk samples were collected from udder secretions of sheep (n=189) and goat (n=100) from El-Fayoum, Beni-Suef, and Giza governorates. Screening subclinical mastitis (SCM) was done using California Mastitis Test (CMT); identification of the isolates was achieved using Gram's staining, hemolytic pattern, colony morphology, and biochemical tests using Analytical Profile Index.


On clinical examination, the incidence of clinical mastitis (CM) was found to be 5.88% and 7% in sheep and goat, respectively. On CMT, SCM was found to be 25 (13.23%) and 11 (10%) in sheep and goat, respectively. Bacteriological examination of all milk samples found the presence of Staphylococcus aureus (SA) (31.1%), coagulase-negative staphylococci (CNS) (19.5%), Escherichia coli (EC) (8.3%), Streptococcus spp. (5.6%), Klebsiella spp. (3.77%), and Pseudomonas spp. (1.89%), while no bacteria were cultured from 81.66% of the samples. Identification of 9 isolates of CNS was achieved by using API staph test to Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus cohnii, and Staphylococcus saprophyticus. The highest bacterial resistance was found in EC (67.14%) followed by Kp (45.28%) and SA (26.57%).


Onion and black cumin essential oils followed by Egyptian honey showed strong antibacterial effects against multidrug-resistant bacteria. Finally, our study proved that Egyptian honey, onion, and black cumin essential oils have a marked strong antibacterial effect against bacteria isolated from small ruminant mastitis, but still further extensive studies are needed to discover the therapeutic properties of these plant extracts and honey.

Monday, April 16, 2018

Propolis and Bee Pollen Protect the Liver

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Influence of Dietary Supplementation of Propolis and Bee Pollen on Liver Pathology in Broiler Chickens

Animals (Basel). 2018 Apr 9;8(4). pii: E54

One of the major problems in intensive breeding of chickens is liver damage. The objective of this study was to determine the influence of dietary supplementation with propolis and bee pollen on liver pathology in broiler chickens. The study was conducted on 200 Ross 308 chickens equally distributed by sex that were divided into five groups. Throughout the whole study, the control group of chickens was fed with a basal diet, while the experimental groups of chickens were fed with the same diet further supplemented with propolis and bee pollen, each supplement given separately or in combination in a certain proportion.

The study showed that the clusters of lymphocytes in the hepatocytes, the vacuolar degeneration and necrosis of the liver parenchyma, the bile ductule hyperplasia, and the various forms of pathological changes in the liver arteries and veins were more frequent in liver tissue samples of the control group compared to liver tissue samples of all the experimental groups (p < 0.001). The study further showed that all the previously mentioned histopathological lesions of liver tissue were always more extensive in the liver tissue samples of the control group than in the liver tissue samples of all the experimental groups (p < 0.001). The supplementation of broiler chickens with propolis and/or bee pollen has a strong protective effect on liver pathology in broiler chickens.

Sunday, April 15, 2018

Bee Venom Used to Treat Arthritis, Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease, Alzheimer's Disease, Liver Fibrosis, Atherosclerosis

Bee venom therapy: Potential mechanisms and therapeutic applications

Toxicon. 2018 Apr 11. pii: S0041-0101(18)30145-4

Bee venom is a very complex mixture of natural products extracted from honey bee which contains various pharmaceutical properties such as peptides, enzymes, biologically active amines and nonpeptide components.

The use of bee venom into the specific points is so called bee venom therapy, which is widely used as a complementary and alternative therapy for 3000 years. A growing number of evidence has demonstrated the anti-inflammation, the anti-apoptosis, the anti-fibrosis and the anti-arthrosclerosis effects of bee venom therapy. With these pharmaceutical characteristics, bee venom therapy has also been used as the therapeutic method in treating rheumatoid arthritis, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, liver fibrosis, atherosclerosis, pain and others.

Although widely used, several cases still reported that bee venom therapy might cause some adverse effects, such as local itching or swelling. In this review, we summarize its potential mechanisms, therapeutic applications, and discuss its existing problems.

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Saturday, April 14, 2018

Propolis Helps Treat Helicobacter pylori (H. pylori) Infections that Cause Ulcers

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Propolis: The future therapy against Helicobacter pylori-mediated gastrointestinal diseases

Journal of Applied Biomedicine
Volume 16, Issue 2, May 2018, Pages 81-99

Helicobacter pylori (H. pylori), which is found in the stomach of approximately 50% of humans, remains there for almost the entire lifetime of the infected individual, leading to various gastrointestinal tract-associated disorders following full-blown infection.

Due to the emergence of antibiotic resistance, recurrence and high cost of therapy, most antibiotic-based treatment strategies are not very effective in eradicating H. pylori infections. The quest for an alternative treatment free of these inconveniences is currently in demand. One of the important alternatives is propolis, produced by the honeybee Apis mellifera, which has been used to treat different diseases since it possesses a wide range of biochemical properties.

Propolis has been reported as a useful therapeutic regimen against H. pylori, which is an important cause of gastric inflammation, peptic ulcer, gastric cancer, and lymphomas of mucosa-associated lymphoid tissues. Apart from propolis, various active compounds of other natural products have also been confirmed to be effective.

This review compiles the scientific evidence of the role of propolis and other natural products against H. pylori-associated gastrointestinal tract-related health complexities by acing as an anti-angiogenic, anti-inflammatory, and antioxidant factor as well as via modulation of enzymatic activities.

Friday, April 13, 2018

Propolis Component May Help Prevent Diabetic Nephropathy

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Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy

Molecules 2018, 23(4), 852

Propolis is a resinous beehive product that has been used worldwide in traditional medicine to prevent and treat colds, wounds, rheumatism, heart disease and diabetes.

Diabetic nephropathy is the final stage of renal complications caused by diabetes and for its treatment there are few alternatives.

The present study aimed to determine the chemical composition of three propolis samples collected in Chihuahua, Durango and Zacatecas and to evaluate the effect of pinocembrin in a model of diabetic nephropathy in vivo. Previous research demonstrated that propolis of Chihuahua possesses hypoglycemic and antioxidant activities. Two different schemes were assessed, preventive (before renal damage) and corrective (once renal damage is established).

In the preventive scheme, pinocembrin treatment avoids death of the rats, improves lipid profile, glomerular filtration rate, urinary protein, avoid increases in urinary biomarkers, oxidative stress and glomerular basement membrane thickness.

Whereas, in the corrective scheme, pinocembrin only improves lipid profile without showing improvement in any other parameters, even pinocembrin exacerbated the damage.

In conclusion, pinocembrin ameliorates diabetic nephropathy when there is no kidney damage but when it is already present, pinocembrin accelerates kidney damage

Thursday, April 12, 2018

Brazilian Green Propolis May Help Treat Colitis

Brazilian green propolis hydroalcoholic extract reduces colon damages caused by dextran sulfate sodium-induced colitis in mice


This study investigated the effects of Brazilian green propolis hydroalcoholic extract (BPE) in 3% w/v dextran sodium sulfate (DSS)-induced colitis in mice.

The effects of BPE (3, 30 and 300 mg/kg, p.o, by 7 days) on the morphological (colon length and colon weight), clinical (disease activity index and weight loss), microscopic (histological score and mucin levels) and biochemical parameters were determined. The effects of BPE (300 mg/kg, p.o) in the gastrointestinal transit of mice were also evaluated.

As expected, the DSS ingestion damaged the colonic tissue, lowered the body weight, decreased the mucin levels, increased MPO activity, reduced SOD activity and GSH amount. In contrast, the treatment with BPE (300 mg/kg) significantly reduced macroscopic colonic injury and the mucosal damage in colon on histopathological examination and reversed the decrease in mucin levels induced by DSS. It also significantly normalized the SOD activity and the levels of GSH, but did not elicit any effect on MPO activity in the colon. In addition, BPE did not change the gastric emptying or the intestinal transit rate of mice.

Together, these results suggested that BPE reduced the signs of DSS-induced colitis in mice through maintenance of intestinal mucin barrier and favoring intestinal antioxidant defenses.


Wednesday, April 11, 2018

NIGERIA: The Health Benefits of Bee Products

Health benefits

The Nation, April 8, 2018

Exploring the heath benefits of bee products in the recent times has been an area which researchers are beaming their search light on due to the wonders which honey and its ally products are recording. According to FAO, there is a considerable history of bees and bee products having medicinal properties. For instance, honey, pollen, propolis, wax, royal jelly and venom are seen by many to have curative properties even though others suggest the contrary as a result of a lack of critical scientific scrutiny on bee products.

However, majority of the bee farmers that spoke to The Nation are very authoritative about the medicinal potency of bees and its products.

Onyema who had been in the business of bee keeping in the last two decades explained that from experience he had cured a lot of diseases with bee products. “We also have bee pollen, it is used as a food for the young bee, and it is a perfect food because it contains all what the body requires. It is also used for fertility in both man and woman. If it is taking for some days, it can also cure prostate cancer in men.”

The bee bread which the bee itself takes is a good medicinal product. “It is useful because of the enzymes present through the worker bee. Royal jelly is one of the precious gems given to the Queen bee. The Queen bee can live up to six years, but the worker bee, for only a month. By taking royal jelly one will be looking younger than ones actual age. It helps in taking care of women infertility. If a woman can be taking it few days to her ovulation period, it will actually boost it.”

According to him, “The bee venom is the stings; it serves as its defensive mechanism, it comes out of the bee lancets, it carries a liquid that it injects into the body, it is poured into the body through venom sack. That is why when it stings you, you can quickly remove it to reduce the venom pumped into the body. This bee venom is telepathic.  I used it to treat a diabetic and arthritics patients.”

Speaking in the same vein, Adegun who had a long romance with bee explained that the healing prowess of the wonderful insect cannot be quantified.  “There are different types of honey. The bitter honey is highly medicinal and there is no disease it cannot treat, blood pressure, diabetes even cancer and skin rashes.

“With honey it can assist against ageing, it can also   be used for preservatives. That is why the old Egyptians usually used honey to embalm their dead bodies.   It is rich in propolis that is good for preservation. It also contains a royal jelly which can be combined with other things and used for fertility drug and impotence.”

He explained that “Through articulated and methodological approach to honey product, a lot of sickness can be cured. Honey can cure some diseases that cannot be emphatically or scientifically proved.”

Given credence to the medicinal efficacy of bee products Prof. Siyanbola said that beeswax is used in food processing industries as an additive and a common ingredient in chewing gum adding that skin care and cosmetic industry are using it in making lips and gloss balm.

The researcher said bee glue is used as antibiotic and anti -fungal agent in the pharmaceutical industries while in natural medicine it is used to treat inflammations, viral disease, ulcers skin burns and scalds...

Major Royal Jelly Proteins Can Reach the Small Intestine When Ingested

The fate of major royal jelly proteins during proteolytic digestion in the human gastrointestinal tract

J Agric Food Chem. 2018 Apr 9

Royal jelly (RJ) is a beehive product with a complex composition, major royal jelly proteins (MRJPs) being the most abundant proteins. Cell culture and animal studies suggest various biological activities for the full-length/native MRJPs.

In the field of apitherapy it is assumed that MRJPs can positively affect human health. However, whenever RJ is administered orally, the availability for assimilation in the gastrointestinal tract is a prerequisite for MRJPs to have any effect on humans.

We here show that MRJPs vary in resistance to Pepsin digestion with MRJP2 being most stable and still present as full-length protein after 24h of digestion. In the intestinal phase, using Trypsin and Chymotrypsin, MRJPs are rapidly digested with MRJP2 again showing longest stability (40 min) suggesting that MRJPs can reach the small intestine as full length proteins but then have to be resorbed quickly if full length proteins are to fulfil any biological activity.

Tuesday, April 10, 2018



About the product
  • Double-Sealed Bottle to Ensure Freshness and Purity
  • 100 Count, Capsule Shell: Vegetable Cellulose
  • Bottled in the United States at an NSF, Organic and Kosher Certified-Facility that Adheres to Good Manufacturing Practices (GMP)
  • Stringent Quality Control Process Monitors Production from Raw Materials to Finished Product
  • Product is Tested and Inspected at Intervals During Manufacture

Brazilian Green Propolis Protects Against Cognitive Decline in the Elderly (Alzheimer's Disease & Dementia)

Brazilian Green Propolis Prevents Cognitive Decline into Mild Cognitive Impairment in Elderly People Living at High Altitude

J Alzheimers Dis. 2018 Apr 4


Systemic inflammation is known as a risk factor of cognitive decline.


To investigate the effects of propolis on cognitive decline and systemic inflammation in elderly people living at high altitude.


Sixty participants (average 72.8 years) living at altitude (2,260 meters) were randomized to receive propolis (0.83 g, n = 30) or placebo (n = 30) for 24 months. Cognitive outcomes were assessed using MMSE and serum cytokine levels were measured for 24 months in a double-blind study.


MMSE scores were 26.17 at baseline and 23.87 at 24 months in placebo group. Compared to placebo group, improvements of MMSE scores were significant in propolis-treated subjects (p  =  0.007) with a response emerging over time (time points×group interaction, p  =  0.016). In addition, the serum IL-1β and IL-6 levels were significantly different across treatments (p  <  0.0001) showing upward and downward trends in placebo- and propolis-treated subjects, respectively (p  <  0.0001). Serum levels of TNF-α were not significantly different across treatment (p  =  0.0528) but with a response emerging over time (time points×group interaction, p  =  0.016). In contrast, serum levels of TGFβ1 were significantly different across treatments (p  <  0.0001) showing downward and upward trends in placebo- and propolis-treated subjects, respectively. Serum levels of IL-10 were significant for the effect of groups (p  =  0.0411). Furthermore, MMSE scores correlated with the decrease in IL-1β and the increase in TGFβ1 in serum.


Elderly people living at high altitude developed to MCI in 24 months with exacerbation of systemic inflammation. Ingestion of propolis (>12 months) protected against cognitive decline after systemic inflammation was reduced.

Monday, April 09, 2018

Bee Venom may Help Treat House Dust Mite-Induced Atopic Dermatitis

Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor

Toxins (Basel). 2018 Apr 2;10(4). pii: E146

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite extract (Dermatophagoides farinae extract, DFE) in a murine model. However, the underlying mechanisms of PLA2 action in actopic dermatitis remain unclear.

In this study, we showed that PLA2 treatment inhibited epidermal thickness, serum immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration in the ear of an AD model induced by DFE and DNCB. In contrast, these effects were abrogated in CD206 mannose receptor-deficient mice exposed to DFE and DNCB in the ear.

These data suggest that bvPLA2 alleviates atopic skin inflammation via interaction with CD206.

Sunday, April 08, 2018

Bee Pollen Extract Lowers Cholesterol, Level of Low Density Lipoproteins (LDL)

Protective Effect of Polyphenol-Rich Extract from Bee Pollen in a High-Fat Diet

Molecules. 2018 Mar 31;23(4)

We have studied a preventive effect of polyphenol-rich bee pollen ethanol extract (EEP) against histological changes in the liver and cardiac blood vessels, abnormalities of lipid profile, and the levels of oxidized low density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) caused by a high-fat diet in C57BL₆ mice.

Supplementing the diet with EEP in the doses of 0.1 g/kg body mass (BM) and 1 g/kg BM resulted in a decrease of total cholesterol by 31% and 35%, respectively. It also decreased the level of low density lipoproteins by 67% and 90%, respectively. No differences in the levels of high density lipoprotein and triacylglycerols were observed. EEP reduced the level of ox-LDL by 33% and 47%, ADMA by 13% and 51%, ACE by 17% and 30%, as well as ANG II by 11% and 15% in a dose-dependent manner, which proves a protective effect of EEP in a high-fat diet. EEP reduces and/or prevents hepatic steatosis and degenerative changes caused by a high-fat diet in C57BL₆ mice, which indicates its hepatoprotective effect.

EEP used with standard feed does not disturb a normal concentration of the assayed parameters.

Saturday, April 07, 2018

Thai Propolis Can Help in Replantation of Avulsed Teeth

Inhibitory effect of Thai propolis on human osteoclastogenesis

Dent Traumatol. 2018 Apr 3


Avulsed teeth should be immediately replanted into the socket or otherwise kept in a physiologic storage medium to maintain periodontal ligament cell viability. A previous study has demonstrated that Thai propolis extract can maintain viability of human periodontal ligament cells. However, root resorption by osteoclasts often occurs when the avulsed teeth are replanted. The aim of this study was to determine the inhibitory effect of Thai propolis extract on human osteoclastogenesis in vitro.


Human peripheral blood mononuclear cells were isolated for osteoclast precursors and cultured in the presence or absence of various non-toxic concentrations of propolis extract, as determined by the alamarBlue® assay, during in vitro induction of osteoclastogenesis. Osteoclast formation was examined by tartrate-resistant acid phosphatase staining, actin ring formation, and real time polymerase chain reaction. The resorption pit assay was performed to determine osteoclast function.


Non-toxic concentrations of propolis extract suppressed osteoclast formation by significantly decreasing the percentages of tartrate-resistant acid phosphatase-positive multinuclear cells and the ratios of cells with F-actin ring formation (P < 0.01) in a dose-dependent fashion. Expression of several osteoclast-specific genes was significantly down-regulated by propolis in a dose-dependent manner (P < 0.05). The percentages of resorption areas on dentin slices were significantly decreased by propolis (P < 0.05).


Thai propolis can inhibit human osteoclast formation and function, which may be beneficial for prevention of root resorption following replantation of avulsed teeth

Friday, April 06, 2018

Royal Jelly Helps Boost Memory, Prevent Signs of Aging

Long-term administration of Greek Royal Jelly decreases GABA concentration in the striatum and hypothalamus of naturally aged Wistar male rats
Neurosci Lett. 2018 Mar 22;675:17-22

Royal Jelly (RJ) is a unique substance obtained from bees that has been used widely in European and Asian traditional medicine for its potential to prevent signs of aging through its antioxidative, anti-inflammatory, anti-hyperglycemic and anti-hypercholesterolemic properties. We recently reported an enhancement in spatial memory along with changes in monoaminergic transmission in aged rats after chronic RJ administration.

Here, we aim to further explore the action of RJ on central nervous system activity by examining levels of amino acids in selected brain structures of aged male Wistar rats following 2-months of Greek RJ administration. RJ powder was previously chemically characterized and given orally (50 or 100 mg of powder/kg b.w./day) by gastric gavage.

The concentrations of amino acids (alanine, aspartic acid, gamma-aminobutyric acid, glutamic acid, histidine and taurine) in the brain regions examined (prefrontal cortex, hippocampus, striatum and hypothalamus) were quantified using HPLC. We also examined basic biochemical parameters of renal and hepatic activity, as damage of these organs could potentially explain the changes in brain function and behavior. Upon biochemical examination, a decrease in the concentration of gamma-aminobutyric acid was observed in both the striatum and hypothalamus. Liver and kidney functions were not changed by chronic RJ-administration.

Our results provide insight toward understanding the mechanism of action of RJ and its effects on neurotransmission in the central nervous system.

Pollen is Rich in Protein, Minerals, Vitamins, Vitamin B12, and Amino Acids

The many benefits of bee pollen

Dear Betty,

Please give me some information on bee pollen. How much to take and the benefits?

Bees produce a variety of products besides honey, the pollen is one of the more than seven different products. Propolis is the most well known of these products. It is resinous material collected from plants used by the bees to seal the cracks or openings in their hives. It is sold in health food stores, used as an additive to skin lotions, soaps, beauty creams, shampoos, lipsticks, toothpaste, chewing gum, mouthwashes, sunscreens, etc. Different plants have different characteristics, making is difficult to get a product with uniform medical properties.

Bee pollen has been called the beef steak of the bee colony and provides more and better nutrition than does the nectar. The pollen is very beneficial containing nearly all the nutrients required by humans.

Pollen is rich in protein, minerals, and vitamins. It is particularly rich in vitamin B12 and amino acids, but its remarkable properties are not fully known. It improves endurance, promotes longevity aids recovery from chronic illnesses and helps prevent some diseases. Bee pollen is a remedy for allergies and hay fever. Like the propolis it has a wide variation in the nutritional value depending on flower source. One teaspoon of pollen takes one bee approximately one month to gather if it works eight hours a day...

Thursday, April 05, 2018

FLASH SALE: Concentrated Bee Propolis - Just $9.95


Propolis From Indian Tribal Region Shows Antibacterial Activity

Antibacterial effect of propolis derived from tribal region on Streptococcus mutans and Lactobacillus acidophilus: An in vitro study

J Indian Soc Pedod Prev Dent. 2018 Jan-Mar;36(1):48-52


The study aimed at investigating in vitro antimicrobial activity of ethanolic extract of propolis (EEP) and water extract of propolis against two main cariogenic oral pathogens: Streptococcus mutans and Lactobacillus acidophilus.

Material and Methodology:

Propolis was obtained from beehives in the Jhabua region of India. Ethanolic and water extracts were prepared at concentrations of 5% and 20% weight/volume (w/v). To support the results, a positive control (chlorhexidine 0.2%) and a negative control (distilled water) were used. S. mutans was cultured on brain-heart infusion agar and L. acidophilus was cultured on De Man, Rogosa, and Sharpe agar.


The results showed that at concentrations of 5% and 20%, EEP was effective against S. mutans and L. acidophilus. However, at similar concentrations, water extract was effective only against L. acidophilus. The highest activity was shown by chlorhexidine (0.2%) with mean zones of inhibition of 13.9 mm and 15.1 mm against S. mutans and L. acidophilus, respectively.


It can be concluded that the propolis extracted from tribal regions of Jhabua possesses antibacterial efficacy against S. mutans and L. acidophilus.

Wednesday, April 04, 2018

Bee Venom Shows Significant Anti-fungal Properties

Antifungal Effects of Bee Venom Components on Trichophyton rubrum: A Novel Approach of Bee Venom Study for Possible Emerging Antifungal Agent

Ann Dermatol. 2018 Apr;30(2):202-210


Bee venom (BV) has been widely investigated for potential medical uses. Recent inadvertent uses of BV based products have shown to mitigate signs of fungal infections. However, the component mediating the antifungal effect has not been identified.


This investigation compares bee venom in its whole and partial forms to evaluate the possible component responsible for the antifungal effect.


Forty-eight plates inoculated with Trichophyton rubrum were allocated into four groups. The groups were treated with raw BV (RBV), melittin, apamin and BV based mist (BBM) respectively and each group was further allocated accordingly to three different concentrations. The areas were measured every other day for 14 days to evaluate the kinetic changes of the colonies.


The interactions of ratio differences over interval were confirmed in groups treated with RBV and BBM. In RBV, the level of differences were achieved in groups treated with 10 mg/100 µl (p = 0.026) and 40 mg/100 µl (p = 0.000). The mean difference of ratio in groups treated with RBV was evident in day 3 and day 5. The groups that were treated with melittin or apamin did not show any significant interaction. In BBM groups, the significant levels of ratio differences over time intervals were achieved in groups treated with 200 µl/100 µl (p = 0.000) and 300 µl/100 µl (p = 0.030).


The the bee venom in its whole form delivered a significant level of inhibition and we concluded that the venom in separated forms are not effective. Moreover, BV based products may exert as potential antifungal therapeutics.

Tuesday, April 03, 2018

SALE: Concentrated Bee Propolis in Veggie Capsules, Produced at Organic and Kosher-Certified Facility

About the product

  • Double-Sealed Bottle to Ensure Freshness and Purity
  • 100 Count, Capsule Shell: Vegetable Cellulose
  • Bottled in the United States at an NSF, Organic and Kosher Certified-Facility that Adheres to Good Manufacturing Practices (GMP)
  • Stringent Quality Control Process Monitors Production from Raw Materials to Finished Product
  • Product is Tested and Inspected at Intervals During Manufacture

Bone Defect Repaired with Graft Preserved in Honey

Surgical management of long bone fractures in cats using cortical bone allografts preserved in honey

Can Vet J. 2018 Apr;59(4):393-396

This report describes comminuted fractures in 2 cats repaired by stabilization with cortical bone allografts that had been preserved in honey. Both cats exhibited appropriate post-operative weight-bearing. Preservation of bone in honey is a simple and widely available alternative for bone banking. This is the first report of a bone defect in cats repaired with bone preserved in honey.

Monday, April 02, 2018

Propolis Helps Treat Oral Lichen Planus

To Evaluate the Efficacy of Topical Propolis in the Management of Symptomatic Oral Lichen Planus: A Randomized Controlled Trial

Contemp Clin Dent. 2018 Jan-Mar;9(1):65-71


Lichen planus (LP) is a chronic inflammatory, autoimmune, mucocutaneous disease of unknown etiology. The first line of treatment for oral LP (OLP) has been corticosteroids, but because of their adverse effects, alternative therapeutic approaches are being carried out, of which the recent natural alternative is propolis.


This study aims to evaluate the efficacy of topical propolis in the management of OLP.

Materials and Methods:

The research group consisted of 27 patients diagnosed with symptomatic OLP, among which 15 patients were in the control group and the rest 12 were in the study group. The patients in the control group received triamcinolone acetonide 0.1% (topical application) while the patients in the study group received propolis gel. Both the groups were evaluated for pain and erythema at baseline (1st visit), first follow-up (7th day), and second follow-up (14th day) using numerical rating scale and modified oral mucositis index.


The patients in both the study and control groups showed a statistically significant reduction (P = 0.000 for the study group and P = 0.000 for the control group) in pain and erythema scores from baseline to second follow-up visit. However, on comparison of the reduction in pain and erythema scores between the two groups, the difference was found to be statistically insignificant (P = 0.255).

Statistical Analysis Used:

Chi-square and Cramer's V test were used.


The topical propolis was found to be of comparative effectiveness with respect to triamcinolone acetonide 0.1% in the management of OLP.

Sunday, April 01, 2018

Propolis May Help Treat Benign Prostate Hypertrophy (BPH)

Caffeic acid phenethyl ester guards against benign prostate hypertrophy in rats: Role of IGF-1R/protein kinase-B (Akt)/β-catenin signaling

IUBMB Life. 2018 Mar 30

Benign prostate hypertrophy (BPH) is among the most common diseases with a huge impact on the quality of life of elderly men. There is a current need for the development of well-tolerated and effective preventive strategies to improve the clinical outcome.

Caffeic acid phenethyl ester (CAPE) is an important active ingredient isolated from honey-bee propolis with potent anti-proliferative, anti-inflammatory and antioxidant effects. These properties promote CAPE as a promising candidate to be tested as an alternative therapy for BPH, which is still uninvestigated. Herein, we tested the ability of CAPE to guard against testosterone-induced BPH and investigated the involvement of IGF1-R/Akt/β-catenin signaling as a protective mechanism in testosterone-induced BPH rat model.

Treatment with CAPE reduced testosterone-induced increase in the prostate index and histopathological alterations. In addition, co-treatment with CAPE significantly suppressed insulin-like growth factor-1 receptor (IGF-1R)/Akt/β-catenin/cyclinD1 axis as well as tumor necrosis factor-α level and nuclear factor (NF)-kB activity. Furthermore, the treatment with CAPE replenished the antioxidant defense systems, superoxide dismutase (SOD) and reduced glutathione (GSH) with subsequent reduction in prostate tissue lipid peroxides.

This study highlights the potential merit of CAPE-enriched propolis formulations to protect elderly men against the development of BPH.

Saturday, March 31, 2018

Propolis May Help Treat Colon and Breast Cancer

Cytotoxic, proapoptotic and antioxidative potential of flavonoids isolated from propolis against colon (HCT-116) and breast (MDA-MB-231) cancer cell lines

Food Res Int. 2018 Apr;106:71-80

Isolated and structurally confirmed, eleven flavonoids from propolis were examined for their cytotoxicity toward human colon cancer and human breast cancer cells. Their effect on induction of apoptosis and their antioxidative activities were also evaluated. Six flavonoids induced cytotoxic effects in both cell lines.

Luteolin had a marked effect on both cell lines, especially on HCT-116 cells (IC50 72h, 66.86μM). Also, luteolin was observed to have the highest apoptotic potential after 72h treatment of examined cell lines (27.13% and 37.09%, respectively). Myricetin exhibited selective inhibition of cell growth (IC50 114.75μM) and induced apoptosis in MDA-MB-231 cells only. Luteolin and galangin exhibited prooxidative properties 24h after the treatment in HCT-116 cells, while myricetin induced prooxidative effects in MDA-MB-231 cells. On the other hand, selected flavonoids exhibited antioxidative properties 72h after the treatment, decreasing superoxide anion radical and nitrite levels in both cell lines.

Cytotoxic and proapoptotic effects on colon and breast cancer cell lines and the influence on their redox status make tested flavonoids good candidates for developing new anticancer drugs.

Friday, March 30, 2018

FLASH SALE: Concentrated Propolis

Just $9.95 - Concentrated Bee Propolis in Veggie Capsules, Produced at Organic and Kosher Facility

Today is World Apitherapy Day

March 30 marks the annual celebration of “World Apitherapy Day," an event designed to enhance international understanding of the therapeutic use and health benefits of bee products.

Apitherapy is the use of bee hive products such as honey, propolis, bee-collected pollen, beeswax, drone larvae extract, bee venom, and royal jelly to maintain good health and in the treatment of a variety of medical conditions.

(Propolis is a resinous substance collected by bees from plants and trees and is used to coat the inside of the beehive and the honeycomb cells with an antiseptic layer. Royal jelly is a substance produced by young worker bees and fed to queens.

March 30 was chosen for World Apitherapy Day because it is the birth date of Dr. Philipp Terc (formerly Filip Tertsch), the first scientific researcher to investigate the medical uses of 'apitoxin," or bee venom. Terc was born on March 30, 1844, in Praporiste, Bohemia (Czech Republic).

Propolis All the Rage in French Pharmacies

Well+Good, March 29, 2018

When a skin-care item starts flying off the shelves in French pharmacies, you know it’s only a matter of time before it reaches cult status here, too. The upcoming star ingredient set to reach this status? Propolis.

Propolis is the resin that bees create out of trees, flowers, and wax, which they carry back to their hives to seal it and keep it sterile. “It’s full of bioflavanoids, it’s antiseptic, and anti-inflammatory,” says Angelina Umansky, the facialist and skin-care guru behind San Francisco’s Spa Radiance. “Bees bring it into their hives so they don’t get diseases.”

The long-time esthetician notes that the ingredient used to be around a lot in the 80s and 90s, but then vanished. “Old is becoming new again,” she says. “It’s in the French and Italian pharmacies, and I’ve seen a whole section for propolis.” It’s back, baby...

Thursday, March 29, 2018

Pectin-Honey Hydrogel Wound Dressings Show Antibacterial Activity

Pectin-honey hydrogel: Characterization, antimicrobial activity and biocompatibility

Biomed Mater Eng. 2018;29(3):347-356


Novel pectin-honey hydrogels have been developed and characterized as medical device. Ideally, a wound dressing should maintain optimal fluid affinity, permit moisture evaporation, protect the wound from microbes, and have shape-conformability, biocompatibility, and antibacterial activity.


A novel, simple and fast method to produce pectin-honey wound dressings is described.


The properties of these pectin-honey hydrogels were investigated, including swelling ability, water vapour transmission rate, hydrogen peroxide production, methylglyoxal content and antibacterial activity. Biocompatibility was assessed by proliferation assays using cultured fibroblast cells and by in vivo study with subcutaneous and intraperitoneal implantation in rats.


Hydrogel showed a good water vapour transmission rate, fluid uptake and were not cytotoxic for fibroblasts. The hydrogel demonstrated good antibacterial activity toward clinically relevant pathogens, including S. aureus and E. coli. Biocompatibility was confirmed by the measurement of plasma levels of interleukin (IL)1 beta, IL-6, tumour necrosis factor (TNF) alpha, and prostaglandin (PG)E2. No histological changes were observed.


The presence of a natural active component, conformability, and complete resorbability are the main characteristics of this new biocompatible biomaterial that is well tolerated by the body, possibly improves healing, may be used for surgical complications prevention, with a simple and inexpensive production process.

Wednesday, March 28, 2018

Honey Helps Boost Exercise Performance

Effects of honey on exercise performance and health components: A systematic review

Effets du miel sur la performance et la santé : revue générale

Science & Sports
Available online 19 March 2018


Honey consists mainly of carbohydrates (CHO), minerals, and vitamins which are properties that are believed able to improve exercise performance and general health. This review aimed to elucidate findings on the effects of honey on exercise performance as well as combined effects of honey and exercise on health-related outcomes.


Literature was searched systematically based on PRISMA guidelines, using PubMed, Science Direct, SPORTDiscus and Web of Science databases. Thirteen human and animal studies were included in the final analysis. Surprisingly, there were only three randomised-controlled studies that investigated the effect of honey on exercise performance per se, meanwhile, ten reported the combined effects of honey and exercise on bone health, hormones, immune system, and inflammation. Acute honey ingestion improved endurance performance in two studies, while, five studies reported improvements in bone health after consuming honey combined with jumping exercises or aerobic dance. One study reported that stress and reproductive hormones were positively regulated. Five studies reported increase in white blood cells and neutrophils after ingesting honey combined with resistance or aerobic exercises which boosted the immune system.


Honey alone could potentially improve aerobic exercise performance; however studies are limited. Meanwhile, honey in combination with exercise promotes bone health and improves immune systems. It is believed that CHO and other constituents of honey play an important role during exercise in exerting the said benefits.



Le miel est principalement composé de glucides, minéraux, et vitamines, susceptibles d’avoir des effets bénéfiques sur la performance à l’exercice et sur la santé. Nous présentons une revue générale des travaux portant sur les effets du miel sur la performance et sur les effets d’une ingestion de miel associée à l’exercice sur la santé.


Une recherche systématique selon les guidelines PRISMA a été effectuée à l’aide des bases de données PubMed, Science Direct, SPORTDiscus et Web of Science. Treize études humaines ou animales ont été retenues pour l’analyse finale. Étonnamment, il n’y avait que trois études randomisées contrôlées investiguant l’effet du miel sur la performance. Dix études portaient sur les effets combinés du miel et de l’exercice sur la santé osseuse, les hormones, le système immunitaire et l’inflammation. Deux études montraient que l’ingestion aiguë de miel améliore la performance lors d’un exercice en résistance. Cinq études objectivaient des améliorations des paramètres de santé osseuse après consommation de miel combinée à des exercices de type saut ou danse aérobie. Une étude a montré un effet bénéfique sur les hormones du stress et de la reproduction. Cinq études ont montré une augmentation des globules blancs et des neutrophiles après ingestion du miel associée à des exercices en résistance ou en endurance qui ont amélioré les fonctions immunitaires. La simple ingestion de miel semblerait améliorer la performance en endurance, mais les données sur cette question restent limitées.


Le miel associé à l’exercice favorise donc la santé osseuse et améliore les fonctions immunitaires. On peut ainsi supposer que les glucides et d’autres constituants du miel jouent un rôle important durant l’exercice en raison de ces divers effets.

Tuesday, March 27, 2018

FLASH SALE: Concentrated Bee Propolis in Veggie Capsules, Produced at Organic and Kosher-Certified Facility, Equals 500 mg of Raw Propolis

JUST $9.95 TODAY on Amazon

About the product
  • Double-Sealed Bottle to Ensure Freshness and Purity
  • 100 Count, Capsule Shell: Vegetable Cellulose
  • Bottled in the United States at an NSF, Organic and Kosher Certified-Facility that Adheres to Good Manufacturing Practices (GMP)
  • Stringent Quality Control Process Monitors Production from Raw Materials to Finished Product
  • Product is Tested and Inspected at Intervals During Manufacture

Honey-Based Gel Helps Treat Skin and Ear Infection in Dogs

In vitro efficacy of a honey-based gel against canine clinical isolates of Staphylococcus pseudintermedius and Malassezia pachydermatis

Vet Dermatol. 2018 Mar 22


Staphylococcus pseudintermedius and Malassezia pachydermatis are important agents in canine pyoderma and otitis.


Determine the in vitro efficacy of a honey-based gel (HBO) against meticillin-susceptible S. pseudintermedius (MSSP), meticillin-resistant S. pseudintermedius (MRSP) and M. pachydermatis, by minimum bactericidal concentration (MBC), minimum fungicidal concentration (MFC) and time-kill assay (TKA). Efficacy of the product's honey component (HO) also was evaluated.


Sixty S. pseudintermedius and 10 M. pachydermatis canine isolates were selected. All isolates were tested against serial dilutions of an HBO containing 40% HO (40%, 20%, 10%, 5% and 2.5% w/v) and HO alone (undiluted, 40%, 20%, 10%, 5% and 2.5% w/v). Microbroth assay followed by subculture was used to determine MBC and MFC. The same protocol was applied after product exposure to catalase. A well-diffusion assay for S. pseudintermedius was used to generate inhibition zones. A TKA for 10 isolates of S. pseudintermedius and 10 isolates of M. pachydermatis was performed.


MBC was 20% w/v (5-20% w/v) for HBO and HO. HBO had lower MBC values when compared to HO (P = 0.003). No statistical difference was observed between MSSP/MRSP isolates (HBO P = 0.757, HO P = 0.743). Only HO was affected by catalase (P = 0.015). MFC for HBO was 10% w/v (5-10% w/v) and 40% w/v for HO (20-≥40% w/v). All isolates were killed after 4 h of exposure.


Staphylococcus pseudintermedius and M. pachydermatis are susceptible to the HBO and these results can be used for future clinical trials.

Monday, March 26, 2018

Honey-Based Mouthwash Helps Treat Cavities, Plaque and Gingivitis

Effectiveness of three mouthwashes - Manuka honey, Raw honey, and Chlorhexidine on plaque and gingival scores of 12-15-year-old school children: A randomized controlled field trial

J Indian Soc Periodontol. 2018 Jan-Feb;22(1):34-39


The aim of this study is to compare the effectiveness of three types of mouthwashes manuka honey (MH), raw honey (RH), and chlorhexidine (CHX) on plaque and gingival scores of 12-15-year-old government school children.

Study Design: 

This study was a double-blind, randomized controlled field trial conducted in Belagavi city, India.

Materials and Methods: 

One hundred and thirty-five government school children aged 12-15 years were randomly selected and allocated into three groups, RH, MH, and CHX mouthwash groups. Ten milliliters each of honey-based mouthwash formulation and CHX mouthwashes (0.2%) were administered according to the group allocation twice daily for 21 days. All the children were examined at baseline, 22nd day (after discontinuation of mouthwash) and 28th day (1 week after discontinuation of mouthwash) for Gingival (Loe and silness 1963) and Plaque Index (Silness and Loe, 1964).


Descriptive statistics was applied for distribution of study participants according to age and gender. One-way ANOVA followed by Tukey's post hoc test and repeated measures ANOVA test followed by Bonferroni's post hoc were applied for inter- and intragroup comparison, respectively. Statistically significant reductions (P < 0.001) in plaque and gingival scores were observed in all the three types of mouthwash groups at the end of the 22nd day and 28th day. MH and RH mouthwash demonstrated equal effectiveness, whereas CHX mouthwash showed the maximum reduction in clinical parameters.


Honey-based mouthwash showed a promising antimicrobial effect on dental caries and plaque and gingival scores.

Sunday, March 25, 2018

Taiwanese Green Propolis Has Significant Antibacterial Activity

Antibacterial activity of propolins from Taiwanese green propolis

J Food Drug Anal. 2018 Apr;26(2):761-768

Taiwanese green propolis is a prenylated flavonoid rich honeybee product and propolins isolated from Taiwanese green propolis exert a broad spectrum of biological activities, such as anti-cancer and anti-oxidant. However, the anti-bacterial effects of Taiwanese green propolis or propolins are still poorly understood.

In the current study, the antibacterial effects of Taiwanese green propolis and propolins were evaluated. Results show that the maximum dry matter yields of Taiwanese green propolis were observed in the 95% and 99.5% ethanol extracts compared to other extraction methods. Consistently, the highest concentration of propolins C, D, F and G from Taiwanese green propolis was obtained in 95% and 99.5% ethanol extracts. Propolins inhibited the growth of gram-positive bacterial strains (Staphylococcus aureus, Bacillus subtilis, Listeria monocytogenes and Paenibacillus larvae).

The average minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of propolins from ethanol extracts were 20 μg/ml. Among the propolins, propolin C had the highest antibacterial activity. Furthermore, Taiwanese green propolis also showed antibacterial activity against methicillin-resistant S. aureus (MRSA).

In conclusion, these results demonstrate that Taiwanese green propolis and propolins have significant antibacterial activity, particularly against gram-positive bacterial strains.

Saturday, March 24, 2018

SAVE 51% - Concentrated Bee Propolis in Veggie Capsules, Produced at Organic and Kosher-Certified Facility, Equals 500 mg of Raw Propolis

SAVE 51% - Concentrated Bee Propolis in Veggie Capsules, Produced at Organic and Kosher-Certified Facility, Equals 500 mg of Raw Propolis

Propolis Helps fight Acne

The Buzzy Ingredient That's Brightening, Acne-Fighting & Youth-Promoting For Sensitive Skin Types

Mind and Body Green, March 19

For all my sensitive skin ladies out there, I present the natural beauty ingredient you need to know about for brightening, acne fighting, and a youthful glow: propolis. This powerful substance, made by honeybees, has been around for centuries yet flown under the radar in modern times, where (often harsh) acids and retinols are touted as the best skin-smoothing ingredients. But if you’re like me and the sheer mention of strong acids and vitamin A derivatives incites the onset of a skin reaction, you’ll be relieved to know about this alternative skin enhancing ingredient.

What is propolis?

I first learned about propolis while interviewing Tanya Hawkes, sustainable beekeeper and founder of organic skin care line Therapi Honey Skincare, who said, "To truly understand what a powerful compound propolis is, you have to look at the plant world. Propolis comes from the giants in the plant kingdom, trees. And trees have evolved to live thousands of years, but in order to do this they have to survive all environmental aggressors: viral, bacterial, pollution, insects, etc. To withstand all of this, trees have created a strong immunity of plant phenol chemicals and bioflavonoids to defend themselves," she said. Bees then piggyback off the trees' powerful immune systems. They harvest the immunity-boosting tree secretions like sap and resin and add enzymes through their body processes, as well as plant and beeswax, to produce an end product that's antiviral, antibacterial, antifungal, anti-inflammatory, and an antioxidant. "The end result is propolis,” she explained.

Wow. Hawkes continued to explain that bees mainly line their hives with propolis as an external immune system but that it can be used in many other ways. For instance, if a mouse were to get inside the hive, which happens with relative frequency, the bees can sting the mouse to death, neutralizing the intruder. But since it’s too large to carry out of the hive, and a decaying rodent would unquestionably bring disease and bacteria, the bees mummify the mouse with propolis, protecting themselves completely from the decaying animal.

Propolis in skin care.

This powerful natural ingredient has become a staple in the natural world. As you might imagine, it can help reduce pigmentation and inflammatory redness, boost collagen, and offer antioxidant protection from environmental aggressors like pollution, sunlight, and radiation.

Personally, I’ve found when using propolis products, my skin appears brighter, and my inflammatory red acne marks fade more quickly. But what I love the most about this ingredient is its ability to produce powerful results gently. Instead of exfoliating my skin with harsh acids to reveal brighter, more youthful skin, propolis allows me to achieve these ends without stripping the skin.

Therapi Honey Skincare’s Propolis + Ultra Radiance Cream is one of my favorite propolis skin care products. I call this cream the "natural alternative to La Mer." It’s made with organic ingredients, including powerful propolis, and offers the perfect blend of water, oil, and waxes to keep my dry, dehydrated skin plump and nourished.

Farmacy’s Honey Potion Renewing Antioxidant Mask is another great option for sensitive skin in need of soothing and revitalizing. The creamy, warming mask contains potent propolis along with another powerful healing substance created by bees: royal jelly, a glandular secretion rich in antioxidants and fatty acids "nurse bees" feed to a larva when they want to turn it into a queen bee.

If I’m dealing with a skin reaction, which undoubtedly happens as a sensitive-skinned beauty blogger (aka guinea pig), in the past I’ve always opted for soothing Manuka honey masks, but recently I’ve discovered and been loving Beekeeper’s Naturals Bee Powdered to quell any irritations. Bee Powered is a potent blend of raw honey, propolis, royal jelly, and bee pollen that makes for a great mask alone or mixed with a spoonful of clay power, like S. W. Basics Hibiscus Mask, for gentle detoxing...

Friday, March 23, 2018

Propolis and Sahara Honeys Prevent Biofilm Formation on Urinary Catheters

Propolis-Sahara honeys preparation exhibits antibacterial and anti-biofilm activity against bacterial biofilms formed on urinary catheters

Asian Pacific Journal of Tropical Disease
Volume 6, Issue 11, November 2016, Pages 873-877


To evaluate the antibacterial effect of Sahara honeys (SHs) against bacterial biofilms formed on urinary catheters in combination with propolis-Sahara honeys (P-SHs).


Three clinical isolates were subjected to biofilm detection methods. The antibacterial and anti-biofilm activity for SHs and P-SHs were determined using agar well diffusion and the percentage of biofilm inhibition (PBI) methods.


The PBI for Gram-positive bacteria [Staphylococcus aureus (S. aureus)] was in the range of 0%–20%, while PBI for Gram-negative bacteria [Pseudomonas aeruginosa and Escherichia coli (E. coli)] were in range of 17%–57% and 16%–65%, respectively. The highest PBI (65%) was produced by SH2 only on E. coli. In agar well diffusion assay, zones of inhibition ranged from 11–20 mm (S. aureus), 9–19 mm (Pseudomonas aeruginosa) and 11–19 mm (E. coli). The highest inhibition (20 mm) was produced by SH1 only on S. aureus. In addition, the treatment of SHs and P-SHs catheters with a polymicrobial biofilms reduced biofilm formation after 48 h exposure period.


SHs and P-SHs applied as a natural agent can be used as a prophylactic agent to prevent the formation of in vitro biofilm.

Thursday, March 22, 2018

Corn Starch Film Containing Propolis Proposed for Wound Dressing, Skin Tissue Engineering

Physicochemical, Antimicrobial and Cytotoxic Characteristics of Corn Starch Film Containing Propolis for Wound Dressing

Journal of Polymers and the Environment pp 1–7

Modern dressings increase the rate of wound healing rather than just covering them. Dressing can protect the injured skin and keep it appropriately moist to speed up the healing process.

In this study, the ethanolic extract of propolis loaded with corn starch was successfully prepared using solvent casting. Characterizations of the samples performed in respect to their mechanical properties were examined by scanning electron microscopy, contact angle, and attenuated total reflectance—fourier transform infrared spectroscopy, as well as antimicrobial capacities.

The MTT assay using fibroblast cells showed the cell viability of corn starch in the ethanolic extract of propolis wound dressing.

The results showed that by increasing the amount of ethanolic propolis extract from 0.25 to 1%, the tensile strength and the Young’s modulus of the samples were decreased, the elongation at the break increased about 15% as compared to the control films, and the contact angle properties were detected by a slightly hydrophobic character of the films in the antibacterial activity against Escherichia coli and Staphylococcus aureus even at low ethanolic extract of propolis concentrations (1%), mainly due to its phenolic compounds.

Therefore, ethanolic extract of propolis loaded with corn starch film will be a potential candidate for wound dressing and skin tissue engineering.

Wednesday, March 21, 2018

Propolis Syrup Delayed Radiation-Induced Esophagitis with Lung Cancer

Efficacy of a Propolis-Based Syrup (FARINGEL) in Preventing Radiation-Induced Esophagitis in Locally Advanced Lung Cancer

Chemotherapy. 2018 Mar 19;63(2):76-82


To evaluate the efficacy of a propolis-based syrup, FARINGEL®, in preventing radiation-induced esophagitis in locally advanced lung cancer patients.


Patients were treated with concurrent chemoradiotherapy (CRT) using involved-field radiotherapy (RT). Every patient received FARINGEL at the beginning of CRT until the first follow-up. The data of the study group were compared with the data of a control group treated without the administration of the syrup.


Forty-five patients were enrolled. Forty-one (91.1%) completed the protocol and were evaluable for esophagitis. Grade ≥2 toxicity occurred in 9/41 patients (22%). No differences in overall toxicity were detected between the study group and the control group (n = 55, 60.9 vs. 54.5%; p = ns). Grade 2-3 esophagitis was lower in the study group in comparison with the control group (22 and 38%, respectively), but statistical significance was not reached (p = 0.09). However, the onset of grade ≥2 esophagitis was delayed in the study group compared to the control group, occurring at higher doses of RT (41.8 vs. 25.4 Gy; p < 0.001). Furthermore, the mean number of interruption days for esophagitis was lower in the study group than in the control group (0.6 ± 2.0 vs. 2.1 ± 3.6; p = 0.025).


FARINGEL was well-tolerated and delayed esophagitis that was induced by CRT for locally advanced lung cancer.

Tuesday, March 20, 2018

Clinical Trial: The Effect of Royal Jelly Vaginal Gel Compared to IUI Technique on Fertility Rate of Women With Low-Fertility Husbands

Brief Summary:

The present Pocock clinical trial study was conducted In the city of Mashhad in Iran between 2015 and 2016. The study inclusion criteria were men with low fertility of sperm motility < 25% and total motility < 50% (asthenozoospermia), no history of endocrine diseases, no diabetes men, no hormonal problems in their wives, and a healthy salpingography in their wives.

The study subjects were voluntarily assigned to royal gel and IUI groups. In royal gel group, 5 grams of royal gel was used after menstruation and every other night before and after intercourse. IUI group received 75 units of FSH from the second day of the cycle. Then vaginal ultrasound was performed from the sixth day of menstrual cycle to determine the right size of follicle. 10000 units of HCG was administered when follicle diameter reached 16mm, and the study subject was prepared for IUI 32-36 hours later. Each subject alternately swapped groups following fertility failure.

Monday, March 19, 2018

Manuka Honey May Help Prevent, Treat Colon Cancer

Inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cells growth. Part 1: Suppression of proliferation, promotion of apoptosis and arrest of cell cycle 

Food & Function, Accepted Manuscript

Numerous investigations have been made on plant phenolic compounds and cancer prevention in recent decades. Manuka honey (MH) represents a good source of phenolic compounds such as luteolin, kaempferol, quercetin, gallic acid and syringic acid.

The aim of this work was to evaluate the chemopreventive effects of MH on human colon cancer HCT-116 and LoVo cells. Both cells were exposed to different concentration of MH (0-20 mg/mL for HCT-116 cells and 0-60 mg/mL for LoVo cells) for 48 h to measure apoptosis and cell cycle arrest as well as apoptosis and cell cycle regulatory gene and protein expression. MH exhibited profound inhibitory effects on cellular growth by reducing the proliferation ability, inducing apoptosis and arresting cell cycle in a dose-dependent manner.

Interestingly, MH treatment in non-malignant cells did not exert any significant toxicity at similar concentration. The apoptosis event was associated with increasing expression of p53, cleaved-PARP and caspase-3, and with the activation of both intrinsic (caspase-9) and extrinsic (caspase-8) apoptotic pathways. MH induced cell cycle arrest at S phase in HCT-116 cells, simultaneously, in LoVo cells, it arrested at G2/M phase through the modulation of cell cycle regulator genes (cyclin D1, cyclin E, CDK2, CDK4, p21, p27 and Rb). The expression of p-Akt was suppressed while the expression of p-p38MAPK, p-Erk1/2 and endoplasmic stress markers (ATF6 and XBP1) was increased for apoptosis induction.

Overall, these findings indicate that MH could be a promising preventive or curative food therapy for colon cancer.

Sunday, March 18, 2018

Propolis Helps Heal Diabetic Foot Ulcers

Topical propolis improves wound healing in patients with diabetic foot ulcer: a randomized controlled trial

Natural Product Research
Formerly Natural Product Letters
Latest Articles

In this randomized controlled trial, diabetic patients with foot ulcers (Wagner grades 1 and 2) were randomly assigned to conventional therapies for diabetic foot ulcer plus topical propolis ointment (5%; twice daily) or conventional therapies alone.

The process of ulcer healing was observed during 4 weeks and compared between the two groups regarding the size, erythema, exudates, white blood cell (WBC) count and erythrocyte sedimentation rate (ESR). The process of ulcer size reduction during the four-week period of study was significantly different between the groups. However, this difference was not significant between the third and fourth weeks. There was no significant difference between two groups regarding erythema and exudate reduction as well as WBC count and ESR.

Administration of topical propolis ointment in addition to the conventional treatments of diabetic foot ulcer could reduce the size of ulcers with Wagner grades 1 and 2.

Saturday, March 17, 2018

NEW PRODUCT: 2:1 Concentrated Bee Propolis in Veggie Capsules, Produced at Organic and Kosher-Certified Facility, Equals 500 mg of Raw Propolis

NEW PRODUCT: 2:1 Concentrated Bee Propolis in Veggie Capsules, Produced at Organic and Kosher-Certified Facility, Equals 500 mg of Raw Propolis

About the product

• Double-Sealed Bottle to Ensure Freshness and Purity
• 100 Count, Capsule Shell: Vegetable Cellulose
• Bottled in the United States at an NSF, Organic and Kosher Certified-Facility that Adheres to Good Manufacturing Practices (GMP)
• Stringent Quality Control Process Monitors Production from Raw Materials to Finished Product
• Product is Tested and Inspected at Intervals During Manufacture

BUY ApisVita Standardized Bee Propolis

Product description

• Propolis, often called “bee glue,” is a natural resinous compound produced by honey bees from botanical sources and is used to seal openings in the hive and to protect its interior from bacteria and fungi. The word “propolis” is derived from the Greek words “pro” (before) and “polis” (city), meaning “before the city” or “defender of the city.” In this case, the “city” is the hive.

• Propolis contains flavonoids, caffeic acid esters and diterpenic acids, which give it bactericidal, antiviral and antifungal properties.

• Propolisis reputed to have antiseptic, antibacterial, anti-mycotic, astringent, spasmolytic, anti-inflammatory, anaesthetic, antioxidant, anti-tumor, anti-fungal, anti-ulcer, anti-cancer, and immunomodulatory effects.

• Propolis has been used in traditional medicine for millennia. Propolis pellets were even found among the grave goods in Paleolithic and Mesolithic burials of northeastern Italy.

“Throughout their 6,000 year civilization, the Egyptians used propolis medicinally as well as for the mummification of cadavers. The ancient Greeks used propolis to speed up the healing of wounds and Aristotle recommended it for all afflictions of the skin. The Roman legionnaires reportedly carried small amounts of propolis with them into battle, not only to help speed up wound healing but for its analgesic (numbing) properties. The Incas used propolis for infections. During the Boer War, the British used it to keep wounds from becoming infected. Throughout history, propolis has played an important role in veterinary medicine since many of the human uses for propolis are applicable to animals.” (Bee Culture Magazine, 10/21/2016)

Brazilian Red Propolis Shows Antimicrobial, Anti-Inflammatory, Antiparasitic, Antitumor, Antioxidant, Metabolic and Nutraceutical Activities

Biological activities of red propolis: a review

Recent Pat Endocr Metab Immune Drug Discov. 2018 Feb 23

• Background: The red propolis (RdProp) is a resin produced by Apis mellifera bees, which collect the reddish exudate on the surface of its botanic source, the species Dalbergiae castophyllum, popularly known in Brazil as "rabo de bugio". Considered as the 13th type of Brazilian propolis, this resin has been gaining prominence due to its natural composition, rich in bioactive substances not found in other types of propolis.

• Objective: This review aims to address the most important characteristics of PV, its botanical origin, the main constituents, its biological properties and the patents related to this natural product.

• Method: By means of the SciFinder, Google Patents, Patus® and Spacenet, scientific articles and patents involving the term "red propolis" were searched until August 2017

• Results: A number of biological properties, including antimicrobial, anti-inflammatory, antiparasitic, antitumor, antioxidant, metabolic and nutraceutical activities are attributed to RdProp, demonstrating the great potential of its use in the food, pharmaceutical and cosmetics industries.

• Conclusion: The available papers are associated to pharmacological potential of RdProp, but the molecular mechanisms or bioactive compounds responsible for each activity have not yet been fully elucidated.