Thursday, September 12, 2019

Medical Grade Honey May Help Treat Vaginal Yeast Infections (vulvovaginal candidiasis)


Sweet Relief: Determining the Antimicrobial Activity of Medical Grade Honey Against Vaginal Isolates of Candida albicans

J Fungi (Basel). 2019 Sep 9;5(3). pii: E85

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Recurrent vulvovaginal candidiasis (RVVC) is predicted to increase to almost 158 million cases annually by 2030. Extensive self-diagnosis and easily accessible over-the-counter (OTC) fungistatic drugs contribute to antifungal-resistance, illustrating the need for novel therapies.

Honey possesses multiple antimicrobial mechanisms, and there is no antimicrobial resistance towards honey reported. We evaluated the susceptibility of five clinical isolates of Candida albicans and a control strain to regular honey and a medical grade honey (MGH) gel formulation (L-Mesitran, containing 40% honey and vitamins C and E) using an adapted version of the EUCAST protocol at pH 5.2, 4.6, and 4.0. 40% regular honey did not kill or inhibit C. albicans.

In contrast, the minimal inhibitory concentration (MIC) of L-Mesitran was 25%-50%, while fungicidal effects occurred at a 50% concentration (MBC) of the MGH formulation, except for one strain which was not killed at pH 4.0. Overall, pH had little effect on antimicrobial activity. MGH formulation L-Mesitran has antimicrobial activity against C. albicans over a relevant pH range. The vitamin supplements or other components of L-Mesitran may enhance the antifungal activity of the honey.

This study supports performing clinical trials for conditions, such as RVVC, to find an alternative to available OTC fungistatic drugs.

Wednesday, September 11, 2019

Man whose penis ‘split’ has it reconstructed with HONEY – and he can now have sex again

The Sun

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...But during an examination it was revealed that the unnamed man was circumcised, according to an article published in the International Journal of Surgery Case Reports.

Medics at Zealand University Hospital discovered the patient had non-cancerous tumours at the root, shaft and tip of his penis, which were infected.

The growths were causing the skin to split - known as penile denudation.

Medics removed the tumours and attempted to reconstruct his member with skin grafts, but the procedure was unsuccessful.

Un-bee-lievable
They then decided to try Manuka honey, renowned for its anti-bacterial, anti-inflammatory and healing properties, the docs said.

Incredibly, the honey dressings had a "satisfying result" and after two weeks healthy tissue had started to fill the wound...

Monday, September 09, 2019

Wedderspoon Debuts New Bee Propolis Throat Spray Line

Wedderspoon Debuts New Bee Propolis Throat Spray Line with Monofloral Manuka Honey at Natural Products Expo East 2019

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MALVERN, Pa.--(BUSINESS WIRE)-- U.S. Leader of Genuine Manuka Honey Unveils Unique Functional Format Combining the Power of Propolis and Manuka to Soothe and Promote Oral Health

Wedderspoon, passionate steward of authentic Manuka Honey-based products and the #1 selling Manuka Honey brand in the U.S., will debut a new line of functional wellness products, Bee Propolis Throat Sprays with Monofloral Manuka Honey, at Natural Products Expo East Sept. 11-14.

Consumers can seek relief with just three sprays of the Bee Propolis Sprays to help soothe throats and support their immune systems. This new line is available in three flavor offerings including Warming Orange Spice, Cooling Chamomile Mint, and Lemon Ginger. Attendees of Natural Products Expo East are invited to booth #1032 to be the first to see the brand’s newest Manuka Honey innovations...

Saturday, September 07, 2019

Royal Jelly Helps Treat Symptoms of Menopause (Hot Flashes, Aging, Ageing, Fatigue, Night Sweats, Osteoporosis, Insomnia, Anxiety, Irritability, Moodiness, Reduced Sex Drive, Vaginal Dryness)

Could royal jelly be an alternative to HRT? Researchers find the expensive honey bee secretion can help alleviate hot flushes and irritability

It’s a creamy substance bottled up and sold alongside claims it can fight ageing
A study now suggests royal jelly could also combat symptoms of the menopause
It was four times more effective at combating hot flushes as placebos, it found
It comes after a bombshell Oxford study last week linked HRT to breast cancer

By STEPHEN MATTHEWS HEALTH EDITOR FOR MAILONLINE 

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It’s a creamy substance bottled up and sold in health food stores alongside bold claims it can boost your sex drive and fight ageing.

But research now suggests royal jelly – secreted by honey bees to feed their queen – could also be used to combat symptoms of the menopause.

Scientists found taking 'bee milk' daily was four times more effective at combating hot flushes as placebos in women going through ‘the change’.

It comes after a bombshell study last week linked HRT – often dished out to alleviate symptoms in menopausal women – to breast cancer...

Friday, September 06, 2019

Honey May Help Treat Malaria, Giardia, Amoebic Dysentery (Gastroenteritis, Diarrhea, Parasites)


In vitro activity of some natural honeys against Entamoeba histolytica and Giardia lamblia trophozoites

Saudi J Biol Sci. 2019 Feb;26(2):238-243

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Considering the potentiality of honey in combating diseases, the present study was carried out aiming to assess the in vitro antiprotozoal activity of several honeys (Ziziphus spina-christi, Acacia nilotica, Acacia seyal, and Cucurbita maxima) against Entamoeba histolytica and Giardia lamblia by employing the sub-culture method.

All the tested honeys inhibited the growth of trophozoites, and the level of inhibition varied according to the assayed concentrations and incubation times. Acacia seyal honey had completely stopped motility of E. histolytica trophozoites at a concentration ≤ 50 µg/ml after incubation for 72 h. Ziziphus spina-christi, Acacia seyal, and Acacia nilotica honeys had completely inhibited the growth of Giardia lamblia trophozoites at concentration ≤ 200 µg/ml after 72 h.

These inhibitory activities were similar to that of Metronidazole™ which showed IC50  = 0.27. The mammalian cytotoxicity of these honeys against normal Vero cell line which determined by applying MTT method verified the nontoxicity of the examined honeys. Also the proximate composition of the samples indicated compliance with the natural honey standards.

The findings of the study indicate the need for in vivo studies and further investigations to identify active principles with antiprotozoal activities from natural honeys.

Wednesday, September 04, 2019

Brazilian Propolis May Help Treat Colitis (Irritable Bowel Syndrome [IBS], Inflammatory Bowel Disease [IBD], Crohn's Disease, Ulcerative Colitis)


Brazilian propolis extract reduces intestinal barrier defects and inflammation in a colitic mouse model

Nutr Res. 2019 Jul 30;69:30-41

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Brazilian propolis is rich in cinnamic acid derivatives and reportedly reduces intestinal inflammation in rodents; however, the underlying mechanisms remain unclear. We hypothesized that the regulation of tight junction (TJ) barrier, Th17 cell differentiation, and/or, macrophage activation by cinnamic acid derivatives were involved in the propolis-mediated anti-inflammatory effect.

Mice were orally administered 2% dextran sodium sulfate (DSS) in combination with either the feeding control or a diet containing 0.3% ethanol extract of Brazilian propolis for 9 days.

DSS administration induced acute colitis in mice, whereas the propolis extract mitigated DSS-induced weight loss; colon shortening; increased plasma levels of lipopolysaccharide-binding protein; reduced expression of TJ proteins, such as zonula occludens, junctional adhesion molecule-A, occludin, and claudins; and increased expression of inflammatory cytokines, such as tumor necrosis factor (TNF) α, interleukin (IL) 6, and IL-17a. Cinnamic acid derivatives, such as artepillin C and caffeic acid phenethyl ester, present in the propolis extract suppressed the IL-17 production from cultured murine splenocytes through decreased retinoic acid-related orphan receptor gT expression. Baccharin, drupanin, and culifolin, which are also present in Brazilian propolis, reduced the TNF-α and/or IL-6 production by suppressing inflammatory signaling in murine RAW 264.7 macrophages.

Taken together, the regulation of Th17 differentiation and macrophage activation by cinnamic acid derivatives, at least in part, contribute to the anti-inflammatory effect mediated by Brazilian propolis.

Monday, September 02, 2019

Royal Jelly Helps Treat Limb-Threatening Diabetic Foot Wounds


Efficacy of a new local limb salvage treatment for limb-threatening diabetic foot wounds - a randomized controlled study

Dove Press

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Background: Diabetic foot ulcer (DFU) is the main risk factor for nontraumatic lower-limb amputation. We hypothesized that by reversing the offending local tissue factors resulting from the low tissue supply of oxygen, inefficient fuel metabolism and acidosis, we can eradicate the infection and help to promote healing. This might be enhanced with the help of an innovated local preparation (PEDYPHAR®,) through its enriched alkaline ointment base and the regenerating growth factors of Royal Jelly (RJ) plus the antimicrobial, immune-modulatory nutritional and other biochemical properties of RJ and Panthenol. We conducted this study to test the safety and efficacy of PEDYPHAR ointment as an adjuvant in limb salvage management for patients with limb-threatening diabetic foot wounds.

Methods: A prospective, randomized, controlled open-label study design with a mean follow-up period of 12 weeks. One hundred and nineteen eligible patients with diabetic foot wounds presenting to 3 outpatient clinics in Egypt were randomized to be treated with the local application of either PEDYPHAR or Panthenol ointment under dressing after conservative debridement of necrotic tissue and irrigation with warm normal saline.

Results: At the end of the 12-week follow-up period, PEDYPHAR showed a higher rate of complete healing of limb-threatening wounds in the intent-to-treat population, 11 of 34 (32.4%) in PEDYPHAR-treated group versus 3/25 (12%) in the Panthenol-treated (control) group (p = 0.034* [*indicates it is statistically significant]).

Conclusion: We can conclude that PEDYPHAR could be an effective and safe conservative local adjuvant treatment for cases of diabetic foot infection.