Thursday, January 17, 2019

Royal Jelly May Help Treat Diabetes

Complementary Therapies in Medicine
Volume 43, April 2019, Pages 20-27

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Highlights

• Royal jelly may help improve glycemic status and oxidative stress in diabetes mellitus.
• Royal jelly effects on lipid profile are contradictory.
• Studies on the Royal jelly effects on inflammatory markers in diabetes mellitus were not enough.
• More studies are required to determine the exact mechanisms of Royal jelly in diabetes mellitus.

Diabetes mellitus is one of the most common endocrine disorders in the world. This systematic review was conducted with focus on the current knowledge on the effect of royal jelly on metabolic variables in diabetes mellitus. PubMed, Scopus, Embase, ProQuest and Google Scholar databases were searched from inception until June 2018. All clinical trials and animal studies that evaluated the effects of royal jelly on diabetes mellitus, and were published in English-language journals were eligible. Studies that provided insufficient outcomes were excluded. Out of 522 articles found in the search, only twelve articles were eligible for analysis. Seven studies showed a significant reduction in FBS, and one reported HbA1c decrease following royal jelly supplementation. Although royal jelly supplementation resulted in significant reductions in HOM A-I R in three studies, the findings on insulin levels were controversial. In addition, royal jelly substantially improved serum levels of triglycerides, cholesterol, HDL, LDL, VLDL and Apo-A1 in diabetes mellitus. In addition, royal jelly resulted in a decrease oxidative stress indicators and increase antioxidant enzymes levels. In conclusion, royal jelly could improve glycemic status, lipid profiles and oxidative stress in diabetes mellitus. However, exploring the underlying mechanisms warrants further studies.

Wednesday, January 16, 2019

Stingless Bee Honey May Help Treat Obesity


Supplementation of Stingless Bee Honey from Heterotrigona itama Improves Antiobesity Parameters in High-Fat Diet Induced Obese Rat Model

Evid Based Complement Alternat Med. 2018 Nov 21;2018:6371582

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Heterotrigona itama is a common stingless bee species found in Southeast Asia. Studies on the health benefits of its honey are limited in comparison with other stingless bee species.

This study examines the antiobesity benefits found in stingless bee honey (SBH) from H. itama. The parameters used to measure the benefits were weight change, morphological structures, and biochemical characteristics. The research was conducted by using rats that were given a high-fat diet (HFD). In total 48 male Sprague Dawley (SD) rats were given a formulated HFD to increase the levels of obesity, the HFD was administered with a value of 0.68 g/cm2.

The duration of the treatment was six weeks, and the results show that the induction obesity using the HFD was successful. Following this, the rats were then treated with SBH (at dosages of 1000 mg/kg, 750 mg/kg or 500 mg/kg), with orlistat or with a placebo. Compared with typical obesity treatment methods, the one that used the three dosages of SBH showed a higher reduction in body mass index (BMI), percentage of body weight gain, adiposity index, and relative organ weight (ROW). The levels of liver enzymes (ALT, AST, and ALP) were also significantly lower in SBH-treated groups. The levels of triglycerides and LDL-cholesterol were significantly lower, while the level of HDL-cholesterol was significantly higher in comparison with the control obese group.

In terms of morphological structures, the number of adipocyte cells was reduced, and the hepatocytes found in the liver were less prone to rupturing when treated with SBH.

In conclusion, the administration of SBH led to an improvement in indicators associated with obesity reduction. SBH also possesses a hepatoprotective potential which can reduce the health risks related to obesity.

Tuesday, January 15, 2019

Propolis Cream Beats Antibiotics in Treating Acne


Natural extracts outweigh synthetic antibiotics for acne treatment

Dermatology Times

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Combined plant-based therapy is more effective for treating mild-to-moderate acne than a synthetic antibiotic. (©ArtfullyPhotographer, Shutterstock.com)

A cream containing natural extracts of propolis, tea tree oil, and Aloe vera has been found to be more effective in reducing mild to moderate acne than a cream containing the synthetic antibiotic erythromycin, research published in Clinical Pharmacology: Advances and Applications shows.

Antibiotics that suppress Propionibacterium acnes are the standard treatment for acne but are becoming less effective due to the emergence of antibiotic-resistant bacterial strains. Clinicians are also encouraged to prescribe fewer antibiotics overall due to the rising threat rise of antimicrobial resistance.

Many plants are known to have innate antimicrobial action, so researchers are increasingly looking to see whether plant-based treatments might be an effective alternative to antibiotics.

This study aimed to evaluate the efficacy of a new cream based on three natural extracts (propolis, “tea tree oil” and “Aloe vera”) in treating mild to moderate acne, comparing it to a cream based on 3% erythromycin and to its vehicle alone (placebo).

The study was conducted at the Skinlab, Department of Biomedical Sciences, University of Sassari, Italy where 60 patients with mild to moderate acne vulgaris were randomly divided into three groups of 20.

All patients were aged between 14 and 34 years; had no more than 20 comedones and 50 papules and pustules; no nodules, cysts, and no more than slight erythematous scarring presence; had not received topical or systemic acne treatments during the previous three months and had previously been responsive to topical erythromycin so were not resistant to it.

Patients were excluded from the study if they were pregnant, lactating, in menopause, had polycystic ovarian syndrome, were taking oral contraceptives, had allergic contact dermatitis or sensitive skin.

Patients in the first group were treated with the new cream containing the three natural extracts - 20% propolis, 3% “tea tree oil” and 10% “Aloe vera” (PTAC). Patients in the second group received the 3% erythromycin cream (ERC) and those in the third group received placebo. Participants were asked to use their allocated cream twice a day, in the morning and in the evening for a total of 30 days and to not use any other acne treatments.

Severity of acne was assessed at baseline, and then after 15 and 30 days, by counting acne lesions through noninvasive measurements and macro-photography.

There were no significant differences between the demographic characteristics of the patients in the three groups at the start of the study. By the end of the study acne severity had improved in patients in both groups receiving active treatments compared to placebo, but patients receiving the PTAC formulation experienced a greater reduction in erythema scars, acne severity index, and total lesion count.

Erythema in papular and scar lesions was more greatly reduced after 15 and 30 days of PTAC and ERC application than with placebo; the PTAC formulation was better than ERC in reducing erythema scars, but there was no difference between the two in reducing papular erythema.

After 30 days treatment, acne severity index (ASI) in the PTAC group had fallen 66.7% compared with 49.7% in the ERC group. Over the same time period, total lesion count (TLC) fell by 63.7% in the PTAC group and 46.5% in the ERC group...

Monday, January 14, 2019

Propolis Boosts Immunity, Antioxidant Activity


Effects of raw propolis or water and ethanol extracts of propolis on performance, immune system, and some blood parameters of broiler breeders

R. Bras. Zootec. vol.47  Viçosa  2018  Epub Nov 08, 2018

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The objective of this study was to determine the effects of raw bee propolis and water or ethanol extract of propolis on growth performance, some blood parameters, and immunoglobulins in 15-20-week-old Ross-308 broiler breeders.

The birds in the control were fed a diet without propolis, whereas the birds in the treatment groups were fed diets with raw propolis (RP), water (WEP), and ethanol (EEP) extract of propolis at the level of 1200, 400, and 400 ppm, respectively. Raw propolis and propolis extracts did not affect body weight gain, feed intake, feed conversion ratio, and some blood parameters, such as aspartate aminotransferase, alanine aminotransferase, total antioxidant status, triglyceride, and phosphorus. Birds fed EEP and those in control group had a lower IgA value compared with birds fed RP. Birds fed RP had higher IgM level than those of the other groups, and birds fed EEP had lower IgM level than those of control and RP-fed group.

The IgY value of breeders fed EEP was higher than those of the other treatment birds, whereas that of WEP-fed birds was higher than those of control and RP treatment. The antibody levels of Anti-Newcastle disease virus and anti-infectious bursal disease virus were higher in EEP and RP-fed groups than those in the control and WEP-fed groups. The WEP decreased total oxidant status value compared with the control and RP treatments, whereas EEP and WEP increased plasma total protein and calcium contents compared with the control. The EEP increased plasma albumin content compared with RP.

The addition of propolis extracts, especially WEP and EEP, to diet improves immunity and antioxidant activity, as well as enhances Ca absorption of broiler breeders.

Sunday, January 13, 2019

Royal Jelly Effective for Nutrition, Menopause, Premenstrual Syndrome, Wound Healing, Diabetes


What are the benefits of royal jelly?



Royal jelly is a creamy white substance with a high nutrient content that young bees make to feed queen bee larvae. There are claims that it offers a range of health benefits, such as easing the symptoms of premenstrual syndrome and supporting wound healing.

Royal jelly is highly nutritious and may have antibacterial, antioxidant, and anti-inflammatory properties. These properties may be responsible for many of the health claims about royal jelly. People usually consume it orally or apply it directly to the skin.

Research suggests that certain nutrients in royal jelly are beneficial for health. However, there is little evidence that these benefits come specifically from royal jelly itself.

In this article, we examine the potential benefits of royal jelly and the science that supports these claims.

Nutrition

Royal jelly contains a high percentage of proteins and carbohydrates.
The nutritional content of royal jelly is a potential benefit in itself as the substance provides a range of essential nutrients that are necessary for good health. Royal jelly comprises:

water (50 to 60 percent)
proteins (18 percent)
carbohydrates (15 percent)
lipids (3 to 6 percent)
mineral salts (1.5 percent)

There are small amounts of vitamins and minerals in royal jelly, including several types of vitamin B. It also contains some polyphenols, which are a type of plant-based chemical that is rich in antioxidants.

Menopause symptoms

Royal jelly may provide relief from the symptoms of menopause.

A 2011 study looked at the effect of a combination of four natural ingredients, including royal jelly, on menstrual symptoms. The researchers gave 120 women either a capsule containing the four ingredients or a placebo twice a day over 4 weeks.

The women in both groups noted a reduction in symptoms, but those who took the capsule had significantly better results than those in the placebo group.

A more recent study found that taking 150 milligrams of royal jelly daily over 3 months could help improve cholesterol levels in healthy postmenopausal women.

Premenstrual syndrome

Royal jelly may also be beneficial for people with premenstrual syndrome.

In a 2014 study, the investigators gave 110 participants either a royal jelly capsule or a placebo once every day over two menstrual cycles. The participants who took the royal jelly capsules had less severe premenstrual syndrome symptoms over the 2 months.

Wound healing

According to some research, royal jelly could speed up the process of wound healing.

The results of a laboratory study in the journal Nutrition Research and Practice showed that royal jelly might significantly increase the movement of fibroblasts to a wound. Fibroblasts are a type of cell that coordinates the process of wound healing.

Type 2 diabetes

There is some evidence that royal jelly may have benefits for people with type 2 diabetes.

In one study, 50 female participants with type 2 diabetes received either a 1-gram dose of royal jelly gel or a placebo once a day for 8 weeks.

The results indicated that taking royal jelly may lead to a reduction in the level of blood glucose. Lower glucose levels in the blood are beneficial for people with type 2 diabetes.

However, the researchers note that more studies with a larger number of participants are necessary.

Friday, January 11, 2019

Quantitation and Seasonal Variation of Key Odorants in Propolis

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J Agric Food Chem. 2019 Jan 10

Application of a comparative aroma extract dilution analysis (cAEDA) to the volatiles isolated from propolis of three consecutive seasons by solvent extraction and solvent-assisted flavor evaporation (SAFE) afforded 48 odorants with flavor dilution (FD) factors ≥ 4, including 21 compounds that have not been previously reported in propolis.

Despite differences in FD factors of some compounds, the overall temporal variation in the odorants was low. Compounds identified with FD ≥ 64 were quantitated by stable isotope dilution assays (SIDAs) and odor activity values (OAVs) were calculated.

Twenty-two compounds showed OAVs ≥ 1, including (E)-isoeugenol (clove; OAV 3700), linalool (floral; OAV 380), butanoic acid (sweaty, rancid; OAV 370), 3-phenylpropanoic acid (floral; OAV 270), 3-methylbutanoic acid (sweaty, rancid; OAV 210), eugenol (clove; OAV 190), and β-ionone (floral; OAV 170).

An odor reconstitution model prepared from deodorized beeswax and the 22 odorants in their natural concentrations closely matched the olfactory profile of authentic propolis.

Thursday, January 10, 2019

Beeswax By-Products Show Antioxidant Effects


Beeswax by-Products Efficiently Counteract the Oxidative Damage Induced by an Oxidant Agent in Human Dermal Fibroblasts

Int J Mol Sci. 2018 Sep 19;19(9)

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The antioxidant capacity and the phytochemical composition of two by-products from beeswax recycling processes were recently investigated.

The aim of the present work was to evaluate the efficacy of one of these by-products, MUD1, against the oxidative stress induced by 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH) in human dermal fibroblast (HDF) cells.

After a preliminary viability assay, the protective effect of MUD1 was investigated through the measurement of apoptosis level, the reactive oxygen species (ROS) and nitrite (NO₂-) production, the level of protein and lipid biomarkers (carbonyl groups, total glutathione and thiobarbituric acid-reactive substance) of oxidative damage, and the measurement of antioxidant enzymes activities (glutatione peroxidase, glutathione reductase, glutathione transferase, superoxide dismutase and catalase).

The obtained results showed that MUD1 exerted protective effects on HDF, increasing cell viability and counteracted the oxidative stress promoted by AAPH-treatment, and improved mitochondria functionality and wound healing capacities.

This work shows the antioxidant effects exerted by beeswax by-products, demonstrating for the first time their potential against oxidative stress in human dermal fibroblast cells; however, further research will be necessary to evaluate their potentiality for human health by more deeply in vitro and in vivo studies.

Wednesday, January 09, 2019

Honey Effective Against Infections, Dental Plaque and Cavities, Gingivitis and Halitosis (Bad Breath)


Honey in oral health and care: a mini review

Journal of Oral Biosciences
Available online 3 January 2019

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Background

Honey is a natural product made from the nectar of flowers by honey bees and has over 200 compounds in it, including sugars, water, organic acids, minerals and polyphenols - the exact structure and composition of honey often determined by which plant source(s) the honey bee took the nectar from. Honey has been used in diets and medicines for thousands of years; however, this review, for the first time, aims to look at its place in modern medicine concerning oral health.

Highlight

The present review for the first time attempted to address the protective effect of honey in the oral care.

Conclusion

For the first time this review addresses the usefulness of honey against Streptococcus mutans infections, dental plaque and caries, gingivitis and halitosis. Honey was also useful in preventing side effects associated with treatment of cancers of the head and neck, namely, radiation induced mucositis, xerostomia and poor wound healing. This is well supported by evidence in literature and was examined in this review.

Tuesday, January 08, 2019

Propolis Exerts Protective Effect Against Ovarian Reperfusion Injury


The protective effect of propolis on rat ovary against ischemia-reperfusion injury: Immunohistochemical, biochemical and histopathological evaluations

Biomedicine & Pharmacotherapy
Volume 111, March 2019

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Highlights

• Ischemia/reperfusion caused increases in cytokines and oxidative-DNA damage in ovary.
• Propolis reversed the biochemical and immunohistochemical parameters in ovarian.
• Propolis restored histopathological changes and reduction of antioxidant enzymes.
• Propolis decreased germ cell apoptosis, DNA and tissue injury, infalammation.

In conclusion, the above findings demonstrate that propolis exerted a protective effect against ovarian I/RI in rats, through the inhibition of oxidative stress, the suppression of inflammatory processes, downregulation of 8-OHdG formations and the inhibition of ovarian cell apoptosis.

Monday, January 07, 2019

Royal Jelly Prevents Fatigue, Anorexia in Renal Cell Cancer Patients


Oral Intake of Royal Jelly Has Protective Effects Against Tyrosine Kinase Inhibitor-Induced Toxicity in Patients with Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled Trial.

Medicines (Basel). 2018 Dec 20;6(1)

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Background: Although tyrosine kinase inhibitors (TKIs) are still recommended as the standard therapy in renal cell carcinoma (RCC), the high frequency of adverse events is a weakness of this therapy. Because royal jelly (RJ) possesses anti-inflammatory and antioxidant properties, we assessed its protective effects on TKI-induced toxicities in RCC patients.

Methods: We enrolled 33 patients with advanced RCC who were assigned to start TKI therapy in combination with a randomized, double-blinded, placebo-controlled RJ trial consisting of a placebo group with 17 subjects and an RJ group with 16 subjects.

Results: Fatigue and anorexia frequencies in the RJ group were significantly lower than in the placebo group (p = 0.003 and 0.015, respectively). A statistically significant correlation between RJ and fatigue or anorexia was detected in sunitinib-treated patients. The dose reduction- or discontinuation-free periods were significantly longer (p = 0.013) in the RJ group than in the placebo group. Furthermore, similar observations were made in sunitinib-treated patients (p = 0.016).

Conclusions: Our clinical trial showed that RJ exerted protective effects against TKI-induced fatigue and anorexia and lowered TKI dose reduction or discontinuation. Hence, RJ is beneficial for maintaining the quality of life and medication compliance in TKI-treated RCC patients.

Sunday, January 06, 2019

Propolis Better Than Erythromycin Cream at Treating Acne, Scars


Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations

Clin Pharmacol. 2018 Dec 13;10:175-181

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Introduction:

Antibiotics that suppress Propionibacterium acnes are the standard treatment for acne but are becoming less effective, due to the appearance of antibiotic-resistant strains. Many plants are known to have innate antimicrobial action and can be used as alternatives to antibiotics; thus, it is necessary to prove their effectiveness in vivo. This study aimed to evaluate the anti-acne efficacy of a new cream based on three natural extracts, comparing it to erythromycin cream and placebo.

Patients and methods:

Sixty patients with mild to moderate acne vulgaris were randomly divided into three groups: treated with cream containing 20% propolis, 3% "tea tree oil", and 10% "Aloe vera" (PTAC) (n = 20); or with 3 % erythromycin cream (ERC) (n = 20); or with placebo (n = 20). At baseline, after 15 and 30 days, investigators evaluated response to treatment by counting acne lesions through noninvasive measurements and macrophotography.

Results:

All the clinical and instrumental values studied were statistically different from placebo except for sebometry, pHmetry, and erythema index values, measured on healthy skin. Unlike in the placebo group, papular and scar lesions showed high erythema reduction after 15 and 30 days of PTAC and ERC application.

Conclusion:

The PTAC formulation was better than ERC in reducing erythema scars, acne severity index, and total lesion count.

Saturday, January 05, 2019

Propolis Effective in Dental and Oral Health (Surgical Wound Healing, Cavity Prevention, Hypersensitivity, Ulcers Avulsed Teeth, Root Canal, Mouthwash)


Applications of Propolis in Dentistry: A Review

Ethiop J Health Sci. 2018 Jul;28(4):505-512

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Background:

Propolis is a resinous substance obtained from the beehives that has antioxidant, anti-bacteria, anti-virus, anti-fungal, anti-tumor and anti-inflammatory activity. The aim of this study was to review the studies about the role of propolis in improving dental and oral health.

Methods:

This study reviewed the published articles regarding the applications of propolis in dentistry. An electronic search of the literature was carried out in Farsi electronic databases including Google, Medlib.ir, SID, Iranmedex and Magiran as well as English electronic databases such as PubMed and ISI Web of Knowledge. These databases were searched for articles published between 1997 and October 20, 2017. Non-dental books and journals were also manually searched.

Results:

This study reviewed published articles on the efficacy of propolis for surgical wound healing, caries prevention, treatment of dentin hypersensitivity, treatment of aphthous ulcers and propolis as a storage medium for avulsed teeth, root canal irrigating solution and mouthwash.

Conclusion:

The result of the reviewed article showed that propolis is effective an agent that is used for multiple purpose in oral health.

Friday, January 04, 2019

Propolis, an Antibacterial of Choice

Honey, propolis and royal jelly: the benefits of the hive

By Thomas Channeton - January 2, 2019

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Honey, wax, pollen, propolis, and venom, the bee alone is responsible for a real pharmacy. The use of the products of the hive to relieve some of the pain is not new. “Apitherapy is a medical very serious and can truly help cure some diseases of everyday life “, explains Dr. Albert Becker, a doctor, a beekeeper and president of the francophone Association of apitherapy (AFA).

And each product of the hive’s interest. In 400 bc J.-C., Hippocrates, boasted already the advantages of the wax to relieve the skin diseases. Secreted in the form of scales by the young workers, it is used in the coatings of medications. In dermatology, it imposes itself as an essential component, because of its protective properties, cosmetic and herbal. The wax integrates in creams, soaps, lotions, coatings for pills, ear plugs noise, molds, dental, bone surgery, suture, etc

Propolis, an antibacterial of choice

Another flagship product of the hive : propolis. The tree resin is collected by bees from the buds of trees ; in Europe, mostly poplar and birch. Transformed into propolis in the hive, it is used in traditional medicine in the prevention of wound infections. “Today, alcoholic extracts modern from propolis of european content guarantee in polyphenols are used for their antioxidant properties high. Its activities antibacterial and antiviral helping to effectively fight germs that infect the teeth, the cavities ENT. Used orally, it is effective in many infections of the gastro-intestinal and uro-genital, in the preventive and curative treatment of the side effects of chemotherapy, ” explains Dr. Becker.

Before adding that its antifungal action is also recognised and used in gynaecological infections. “The propolis also has a major interest in the fight against certain viruses such as influenza, HIV, herpes, HPV virus responsible for cancers. It is also effective as an anti-inflammatory and acts favorably on the immune system, but can also be allergenic “...

Thursday, January 03, 2019

Chinese Doctor Uses Bee Stings to Treat Pain


TCM doctor raises honey bees, claims painful bee-sting treatments really work

Global Times Published: 2019/1/3

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A traditional Chinese medicine (TCM) doctor in South China treating patients with bee stings has gained popularity through a viral video.

The method is known as apitherapy, which uses honey bee products like bee venom to treat many illnesses and alleviate pain. Apitherapy is a branch in TCM with a long history.

The TCM doctor She Ruitao uses tweezers to hold honeybees on a patient's skin, forcing it to sting the patient, according to a Yishou Video.

"It hurts," one patient shrieks. "It reduces swelling and alleviates pain," another patient said...

Wednesday, January 02, 2019

Chilean Propolis Exhibits Antimicrobial Activity, Decreases Biofilm Proliferation

Antimicrobial and Antibiofilm Activity against Streptococcus mutans of Individual and Mixtures of the Main Polyphenolic Compounds Found in Chilean Propolis

BioMed Research International
Volume 2019, Article ID 7602343, 7 pages

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Dental caries is multifactorial disease and an important health problem worldwide. Streptococcus mutans is considered as a major cariogenic agent in oral cavity. This bacteria can synthetize soluble and insoluble glucans from sucrose by glucosyltransferases enzymes and generate stable biofilm on the tooth surface.

Biological properties of Chilean propolis have been described and it includes antimicrobial, antifungal, and antibiofilm activities. The main goal of this study was to quantify the concentrations of main flavonoids presents in Chilean propolis and compare some biological properties such as antimicrobial and antibiofilm activity of individual compounds and the mixture of this compounds, against S. mutans cultures. Chilean propolis was studied and some polyphenols present in this extract were quantified by HPLC-DAD using commercial standards of apigenin, quercetin, pinocembrin, and caffeic acid phenethyl ester (CAPE).

MIC for antimicrobial activity was determined by serial dilution method and biofilm thickness on S. mutans was quantified by confocal microscopy. Pinocembrin, apigenin, quercetin, and caffeic acid phenethyl ester (CAPE) are the most abundant compounds in Chilean propolis. These polyphenols have strong antimicrobial and antibiofilm potential at low concentrations. However, pinocembrin and apigenin have a greater contribution to this action.

The effect of polyphenols on S. mutans is produced by a combination of mechanisms to decrease bacterial growth and affect biofilm proliferation due to changes in their architecture.