Sunday, July 15, 2018

Dietary Propolis Polyphenols May Help Treat Type 2 Diabetes

Dietary polyphenols and type 2 diabetes: Human study and clinical trials

Crit Rev Food Sci Nutr. 2018 Jul 11:1-19

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Significant evidence from epidemiological investigations showed that dietary polyphenols might manage and prevent type 2 diabetes (T2D). This review summarizes human studies and clinical trials of polyphenols as anti-diabetic agents.

Polyphenols from coffee, guava tea, whortleberry, olive oil, propolis, chocolate, red wine, grape seed, and cocoa have been reported to show anti-diabetic effects in T2D patients through increasing glucose metabolism, improving vascular function as well as reducing insulin resistance and HbA1c level. However, individual flavonoid or isoflavonoid compounds appear to have no therapeutic effect on diabetes, based on the limited clinical data. Preliminary clinical trials provided evidence that resveratrol had anti-diabetic activity in humans by improving glycemic control in subjects with insulin resistance. Besides, anthocyanins exhibited anti-diabetic properties by reducing blood glucose and HbA1c levels or the improvement of insulin secretion and resistance. The structure-activity relationship of polyphenols as anti-diabetic agents in humans has been rarely reported.

Saturday, July 14, 2018

New Zealand Thyme, Manuka and Honeydew Honeys May Help Treat Prostate Cancer

Honey reduces the metastatic characteristics of prostate cancer cell lines by promoting a loss of adhesion

PeerJ. 2018 Jul 3;6:e5115

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Honey has been shown to have a range of therapeutic effects in humans, with anti-inflammatory and anti-bacterial effects among those previously characterised.

Here, we examine the possibility of New Zealand thyme, manuka and honeydew honeys, and their major sugar and phenolic components, reducing the development of metastatic cancer.

Their activity was examined in vitro, in PC3 and DU145 prostate cancer cell lines, through measuring the compounds' effects on the metastatic characteristics of migration, invasion and adhesion. First, the phenolic compounds gallic acid, caffeic acid, quercetin, kaempferol and chrysin were quantified in the honeys using high performance liquid chromatography, and found in nanomolar concentrations.

In a Boyden chamber-based migration assay, non-toxic concentrations of thyme and honeydew honeys reduced cell migration by 20%, and all phenolic compounds except caffeic acid also lowered migration, although a mixture of only the sugars found in honey had no effect. All of the honeys, phenolics and the sugar-only mixture reduced invasive movement of cells through extracellular matrix by up to 75%.

Most notably, each of the three honeys and the sugar-only mixture reduced cell adhesion to collagen I by 90%. With the exception of quercetin, phenolic compounds did not reduce adhesion.

Therefore, honey and its sugar and phenolic components can lower the metastatic properties of cancer cells, and may do this by preventing effective cell adhesion to the extracellular matrix. The sugars and phenol compounds of honey are much more effective in combination than individually.

Friday, July 13, 2018

Manuka Honey May Help Prevent Cavities

Manuka Honey: A Potent Cariostatic Agent- An in vitro Study

Int J Clin Pediatr Dent. 2018 Mar-Apr;11(2):105-109

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Aim:

The aim of the study was to test the antibacterial activity of manuka honey and compare its efficacy with another commercially available honey (Dabur honey) on the cariogenic bacteria on Streptococcus mutans and Lactobacillus.

Materials and methods:

An in vitro study was carried out on 40 agar specimens; the samples were divided into two groups of 20 samples consisting of S. mutans and Lactobacil-lus respectively. The 20 samples in each group were further subdivided into four groups of five each, which were tested with 25% manuka honey, 100% manuka honey, 25% Dabur honey, and 100% Dabur honey for both Lactobacillus and S. mutans groups. The antibacterial activity was tested using the agar well diffusion method against S. mutans and Lacto-bacillus. Antibacterial activity was assessed by measuring the diameter of inhibition of zones surrounding the wells. The results obtained were statistically analyzed (one-way analysis of variance test, p-value).

Results:

The results showed that 25% of manuka honey has statistically significant (p ≤ 0.001) antibacterial effect than 25% of Dabur honey on both Streptococcus and Lactobacillus species, and manuka honey with 100% concentration showed a statistically significant (p ≤ 0.001) antibacterial effect than 100% Dabur honey on the same species of bacteria. 100% of both the honeys showed statistically significant (p ≤ 0.001) antibacterial effect than 25% concentrations of the same on S. mutans and Lactobacillus.

Conclusion:

Manuka honey had more antibacterial activity than Dabur honey on S. mutans and Lactobacillus bacteria in the in vitro study. This effect was dependent on the concentration of honey used.

Thursday, July 12, 2018

Honey More Effective Than Povidone Iodine in Preventing Peritoneal Dialysis Catheter-Related Infections

A Retrospective Sequential Comparison of Topical Application of Medicated Honey and Povidone Iodine for Preventing Peritoneal Dialysis Catheter-Related Infections

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Perit Dial Int. 2018 Jul-Aug;38(4):302-305

Application of medicated honey (MH) to peritoneal dialysis (PD) catheter exit sites has been found to be as effective as intra-nasal mupirocin for preventing PD catheter-related infections (CRIs), but was associated with increased risk for CRIs in diabetics. The efficacy of topical MH as a prophylactic agent has not been compared with the exit-site application of povidone iodine (PI). This retrospective multicentre cohort study compared cumulative incidence rates of PD CRIs (peritonitis or exit-site infections) and the number of PD CRIs observed per patient over the study period with PD exit-site application of MH or PI, in both diabetic and non-diabetic patients.

Outcomes were compared in incident patients in 2 eras: January 2011 - December 2012, when 147 received exit-site care with PI (PI group), and July 2013 - June 2015, when 171 patients applied MH (MH group). Patients were followed until technique failure, death, transplant, or end of study treatment era. Cumulative incidence of PD CRIs was higher in the PI group (hazard ratio [HR] = 1.7, 95% confidence interval [CI] 1.1 - 2.6, p = 0.019) and the benefit of MH was not modified by diabetic status (present/absent, interaction p = 0.723). A similar trend was observed in the cumulative incidence of peritonitis (HR = 1.6, 95% CI 0.99 - 2.6, p = 0.059). After adjusting for months of exposure, the rate ratio for PD CRIs was 1.58 for PI compared to MH (95% CI, 1.03 - 2.42, p = 0.035).

We conclude that exit-site application of MH is more effective than PI in preventing PD CRIs, and this effect is not modified by the presence or absence of diabetes.

Wednesday, July 11, 2018

Propolis Helps Treat Palmoplantar Psoriasis


Apitherapy as a New Approach in Treatment of Palmoplantar Psoriasis

Open Access Maced J Med Sci. 2018 Jun 10;6(6):1059-1061

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BACKGROUND:

Apitherapy is the medical use of honey bee products, "honey, propolis, royal jelly, bee wax, and bee venom to relieve human ailments. Propolis is one of the most well-documented products derived from the honeybee and has always played an important role in traditional folk medicine.

AIM:

The aim was to justify the consideration of Aloe Vera as an effective remedy for the treatment of psoriasis.

METHODS:

The study follows (857) patients (354 females, 503 males) with a mean age range from (9 - 62) years, affected with moderate to severe psoriasis in palms and foot soles treated by a combination mixture of propolis and Aloe in the form of an ointment (Aloreed) and Beauty reed cream. The treatment duration was for 12 weeks. Results were evaluated by using clinical, histological and statistical parameters.

RESULTS:

After the 12 - week treatment, we observed an 86% overall response rate from which 62% showed excellent results and 24% showed good results, therefore proving the efficiency in the use of the mixture of propolis 50% and aloe vera 3% as topically applied ointment in the treatment of mild to moderate psoriasis.

CONCLUSION:

Patients who have palmoplantar psoriasis, who were treated with a topically applied mixture of propolis (50%) and aloe vera (3%), have shown noteworthy improvement thus proving the efficiency of propolis and aloe vera in the treatment of mild to moderate psoriasis.

Monday, July 09, 2018

Propolis May Help Treat Stomach Ulcers (gastric inflammation, peptic ulcer, gastric cancer, and lymphomas)


Propolis: The future therapy against Helicobacter pylori-mediated gastrointestinal diseases

Journal of Applied Biomedicine
Volume 16, Issue 2, May 2018, Pages 81-99

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Helicobacter pylori (H. pylori), which is found in the stomach of approximately 50% of humans, remains there for almost the entire lifetime of the infected individual, leading to various gastrointestinal tract-associated disorders following full-blown infection.

Due to the emergence of antibiotic resistance, recurrence and high cost of therapy, most antibiotic-based treatment strategies are not very effective in eradicating H. pylori infections. The quest for an alternative treatment free of these inconveniences is currently in demand. One of the important alternatives is propolis, produced by the honeybee Apis mellifera, which has been used to treat different diseases since it possesses a wide range of biochemical properties.

Propolis has been reported as a useful therapeutic regimen against H. pylori, which is an important cause of gastric inflammation, peptic ulcer, gastric cancer, and lymphomas of mucosa-associated lymphoid tissues. Apart from propolis, various active compounds of other natural products have also been confirmed to be effective.

This review compiles the scientific evidence of the role of propolis and other natural products against H. pylori-associated gastrointestinal tract-related health complexities by acing as an anti-angiogenic, anti-inflammatory, and antioxidant factor as well as via modulation of enzymatic activities.

Sunday, July 08, 2018

Australian Native Leptospermum Spp. Honey Has Potential to Surpass New Zealand’s Manuka Honey for Both Activity and Scale


CATCH THE BUZZ – OZ MAY HAVE BETTER MANUKA THAN NEW ZEALAND AFTERALL

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Bee Culture

Australia is home to 85 of the world’s 87 leptospermum species. (Photo: Sunshine Coast University)

Australian native leptospermum spp. honey has the potential to surpass New Zealand’s Manuka honey for both activity and scale.

Australia is the homeland of leptospermum with 84 of the world’s 87 species/

But in Queensland, University of the Sunshine Coast (USC) PhD researcher Simon Williams says the testing shows not all Aussie Leptospermum are equal.

Some have been found not to have the precursor compound dihydroxyacetone in their nectar while others are more active than leptospermum scoparium.

Manuka honey derived from New Zealand’s sole leptospermum tree, leptospermum scoparium is the gold standard in medicinal honey.

Scientists in the USC honey research laboratory have been working on understanding Australian leptospermum honeys for the last seven years.

They have found Australian honeys are comparable or better than New Zealand’s Manuka honey.

“Every state has bioactivity, but it has very large range, which is one of the complications in Australia,” Williams says...

Saturday, July 07, 2018

Propolis Emulgel: A natural remedy for burns and wounds.

Drug Dev Ind Pharm. 2018 Jul 5:1-41

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OBJECTIVES:

To develop an alternative medicine, propolis, in emulgel formulation for burn and wound treatment.

METHODS:

The effect of two independent variables: emulsifying agent concentration and oil concentration on the cumulative amount of propolis release (dependent variable) from liquid paraffin and isopropyl palmitate emulgels was investigated. Eight formulations were prepared and evaluated for physical appearance, pH, propolis content, viscosity and in vitro propolis release. The release results were fitted into different kinetic equations and analysed using contour plot, interaction surface plot and one-way ANOVA. The selected emulgel formulation was investigated for its wound and burn healing activity in rats.

RESULTS:

All the prepared emulgels showed acceptable physical properties concerning colour, homogeneity, consistency, and pH value. The concentration of emulsifying agent had more pronounced effect on propolis release than oil concentration. Formulations F1-F6 showed "anomalous" drug release, while Formulations F7 & F8 showed zero-order kinetic.

CONCLUSIONS:

The formulation F7 with 5% isopropyl palmitate, 5% emulsifier mixture, 1% hydroxyl propyl methyl cellulose, 1% oleic acid and 10% propylene glycol is a promising formula for better management of wound and burn.

Friday, July 06, 2018

Royal Jelly Shows Anti-Inflammatory, Bactericidal Activity to Benefit Human Gastrointestinal Tract

10-hydroxy-2-decenoic acid of royal jelly exhibits bactericide and anti-inflammatory activity in human colon cancer cells

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BMC Complement Altern Med. 2018 Jul 3;18(1):202

BACKGROUND:

Royal jelly (RJ), the exclusive food for the larva of queen honeybee, is regarded as the novel supplement to promote human health. The function of RJ may be attributed to its major and unique fatty acid, 10-hydroxy-2-decenoic acid (10-HDA). The current study investigated the anti-inflammory function of 10-HDA on human colon cancer cells, WiDr, as well as its effect on the growth of pathogenic bacterium.

METHODS:

The pro-inflammatory cytokines, receptor antagonist cytokine (IL-1ra) and nuclear factor-kappa B (NF-κB) in WiDr cells was analyzed by Enzyme-linked immunosorbent assay (ELISA) or western blot. The growth inhibition of 10-HDA on bacterium was evaluated by determination of minimal inhibitory concentrations (MIC) and minimal bactericide concentrations (MBC).

RESULTS:

The production of pro-inflammatory cytokines, Interleukin (IL)-8, IL-1β and tumor necrosis factor-alpha (TNF-α) in WiDr cells was modulated by 10-HDA. IL-8 were dramatically declined by 10-HDA at 3 mM, while IL-1β and TNF-α were significantly decreased. 10-HDA increased IL-1ra in a dose manner. NF-κB pathway is primarily in response to prototypical pro-inflammatory cytokines, and NF-κB was reduced after 10-HDA treatment. 10-HDA acted as potent bactericide against animal- or human-specific pathogens, including Staphylococcus aureus, Streptococcus alactolyticus, Staphylococcus intermedius B, Staphylococcus xylosus, Salmonella cholearasuis, Vibro parahaemolyticus and Escherichia coli (hemolytic).

CONCLUSIONS:

The current study showed that in vitro 10-HDA from RJ exhibited anti-inflammatory activity in WiDr cells, as well as anti-bacterial activity against animal pathogens. 10-HDA showed its potential as anti-imflammtory agent and bactericide to benefit human gastrointestinal tract.

Thursday, July 05, 2018

Even Low Concentrations of Propolis Tincture Killed More Than 99% of Salivary Bacteria

Activity of preparations from Spilanthes oleracea, propolis, Nigella sativa, and black garlic on different microorganisms involved in oral diseases and on total human salivary bacteria: A pilot study

Phytother Res. 2018 Jun 25

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Due to continuous rise in antibiotic resistance, there is a need for alternative treatment options to reduce the levels of oral pathogens for the maintenance of oral as well as overall health. The aim of this study was to evaluate the in vitro antibacterial potential of tinctures of Spilanthes oleracea and propolis, Nigella seed oil, and an ethanolic extract of black garlic on microorganisms involved in oral diseases. Both the minimum inhibitory concentration assay and the minimum bactericidal/fungicidal concentration assay were used in this study. Inhibition effects against total human salivary bacteria were also determined.

Our results show that all of the preparations tested had potent antimicrobial activities. When measured 10 min after exposure, even low concentrations of the propolis tincture were found to have killed more than 99% of salivary bacteria, whereas Spilanthes tincture and black garlic extract killed more than 90% and Nigella seed oil more than 60% of the pathogens.

This suggests that all preparations are promising candidates for the use in oral health care products and that all have the potential to control biofilm associated infections.

Wednesday, July 04, 2018

New Zealand Kanuka Honey Helps Treat Actinic Keratosis (Squamous Cell Cancer)


Successful Treatment of Actinic Keratosis with Kanuka Honey

Case Rep Dermatol Med. 2018 May 31;2018:4628971

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Actinic keratoses form as rough, scaly plaques on sun-exposed areas; they can be an important step in premalignant progression to squamous cell cancer of the skin. Currently, pharmacological treatments consist of topical immunomodulatory agents with poor side effect profiles.

Use of honey has been common in both ancient and modern medicine, where it is now a key therapy in the management of wound healing. In vitro studies show the New Zealand native Kanuka honey to have immunomodulatory and antimitotic effects, with recent evidence suggesting efficacy of topical application in a variety of dermatological contexts, including rosacea and psoriasis.

Here, we present a case report of a 66-year-old gentleman with an actinic keratosis on his hand, which had been present for years. Regular application of Kanuka honey over three months resulted in remission immediately following the treatment period with no signs of recurrence at nine months.

Tuesday, July 03, 2018

Medical-Grade Honey Helps Treat Wounds Associated with Cochlear Implant Wounds in Pediatric Patients

The use of honey in cochlear implant associated wounds in pediatric patients

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Int J Pediatr Otorhinolaryngol. 2018 Aug;111:80-83

INTRODUCTION:

The use of honey in wound care is becoming more common due to the proven benefit in all three phases of wound healing, as well as the antibacterial and antibiofilm properties. We present our experience using TheraHoney gel, a medical grade honey, for the successful treatment of cochlear implant associated skin breakdown.

OBJECTIVE:

To describe the role of TheraHoney gel in the management of cutaneous infection and ulceration associated with cochlear implants.

METHODS:

Three cases of wounds treated traditionally with antibiotics, plus the addition of TheraHoney, were retrospectively reviewed. The first patient had a superficial 1 × 1 cm ulcer, the second patient had bilateral ulcers: one superficial 1.5 × 1.5 cm ulcer and the other a 1.5 × 2 cm stage III pressure ulcer with an exposed receiver stimulator, and the third patient with a 3 × 3.5 cm stage III ulcer with an exposed receiver stimulator.

RESULTS:

With the addition of TheraHoney gel, complete wound closure was achieved at all three patients without the need for surgical reconstruction.

CONCLUSION:

Cutaneous infection with or without skin breakdown is a common delayed complication after cochlear implantation. We demonstrate the efficacy of adding medical grade honey in promoting healing in infected scalp pressure ulcers overlying the cochlear implant site.

Monday, July 02, 2018

Propolis Can Help Stabilize Natural Beauty Products


Is Propolis the Key to Safe Natural Emulsion Products? - Chromatography Explores

Chromatography Today

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As consumers become more conscious of their health and the effect they can have on the environment they turn to natural and organic products. In a 2018 UK report, the Soil Association reported that the growth in the UK market for organic food and drink increased for the sixth year in a row, this time by 6% with total sales of £2.2 billion.

And it is not just food and drink products that are seeing an increase in sales. In 2017, the Soil Association reported that sales of health and beauty products increased by over 20% — with the UK market worth over £61 million. A recent paper published in the Saudi Pharmaceutical Journal — Effect of poplar-type propolis on oxidative stability and rheological properties of O/W emulsions — has investigated whether propolis can help to make natural beauty products stable.

Sunday, July 01, 2018

Propolis Reduces Risk of Colon Cancer (changes in bowel habits, diarrhea, constipation, rectal bleeding, cramps, sudden weight loss, weakness, and fatigue)


Propolis can reduce the risks of Colon cancer, study claims

Top Health Journal

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Honey isn’t the only product by the bees. Bees also produce a greenish-blue, glue-like substance named “Propolis”. It is a mixture of bees’ saliva, beeswax, and the nectar they collect from flowers and buds. Propolis is used by the bees for coating their hives and sealing the superfluous gaps present in it.

History also reveals plentiful benefactions offered by propolis. It has long been used by the Greeks to treat swelling and blisters while the Assyrians treated infections with propolis and used it to improve the process of healing. The Egyptians used it to prevent the decay of mummies.

In addition, a recent study has proved propolis to be effective against the spreading of colon cancer.

Colon cancer is the third most frequently occurring cancer all around the globe. One individual in every twenty people is diagnosed with colon cancer. Colon cancer is caused by genetic alterations inside the body which causes the Polyps to turn into cancerous cells. Polyps are present naturally underlying the gut region. At the point of initiation, polyps form small and benign clumps of cells which over the time turn metastatic causing the death of the organism directly.

The symptoms of the diseases include changes in bowel habits, diarrhea, constipation, rectal bleeding, cramps, sudden weight loss, weakness, and fatigue...

Saturday, June 30, 2018

Bee Pollen May Help Treat Neurological Disorders

Therapeutic and Protective Potency of Bee Pollen Against Neurotoxic Effects Induced by Prenatal Exposure of Rats to Methyl Mercury

J Mol Neurosci. 2018 Jun 26

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MeHg is a widely distributed environmental toxicant with harmful effects on the developing and adult nervous system.

This study aimed to evaluate the therapeutic and protective efficacy of pollen grain in improving the toxic effects of MeHg, through the measurement of selected biochemical parameters linked to oxidative stress, energy metabolism, and neurotransmission in brain homogenates of male pups' neonates.

Forty healthy pregnant female rats were randomly divided into five groups, and after delivery, each group was consisting of 10 male neonates: (1) neonates delivered by control mothers, (2) neonates delivered by bee pollen treated mothers who received bee pollen at the dose of 200-mg/kg body weight from postnatal day 0 for 4 weeks, (3) neonates delivered by MeHg-treated mothers who received MeHg at the dose of 0.5 mg/kg/day via drinking water from gestational day 7 till postnatal day 7 of delivery, (4) therapeutic group: neonates delivered by MeHg-treated mothers followed by bee pollen treatment who received bee pollen at the dose of 200-mg/kg body weight from postnatal day 0 for 4 weeks, and (5) protective group: neonates delivered by MeHg and bee pollen-treated mothers. Mothers continued receiving the bee pollen at the same dose until day 21.

Biochemical parameters linked to oxidative stress and energy metabolism and neurotransmission were investigated in brain homogenates of neonates from all the five groups. MeHg treatment showed an increase in oxidative stress markers like lipid peroxidation and catalase activity coupled with a non-significant decrease in glutathione level. Impaired energy metabolism was ascertained via the inhibition of creatine kinase and lactate dehydrogenase activities.

Dramatic decrease of Mg2+ and K+ concentrations confirmed the neurotransmission defect. Interestingly, the bee pollen treatment was highly effective in restoring the catalase, lactate dehydrogenase, and creatine kinase activities in addition to normalizing the levels of Mg2+, K+, lipid peroxidation, and glutathione.

Overall, the exposure to MeHg during the developing brain stages was highly effective to show signs and symptoms of neuronal toxicity. Furthermore, it has been concluded that bee pollen can be used safely to ameliorate oxidative stress, poor detoxification as well as metal ion defects, and neuronal death as a critical mechanisms involved in the etiology of numerous neurological disorders.