Monday, September 16, 2019

Honey and Propolis May Help Reduce Stress in Women

Glucocorticoid and cortisol hormone in response to honey and honey propolis supplementation in mild stress women

Enferm Clin. 2019 Sep 10. pii: S1130-8621(19)30297-9

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OBJECTIVE:

This study aimed to assess the response of supplementation of honey and honey propolis to women who experience mild stress.

METHODS:

The subjects of 30 people were divided into 3 groups; control, honey, and propolis honey every 10 people per group. All groups were given the same dose of 60g/day for 14 days. Measurements of glucocorticoid and cortisol hormones using Enzyme-Linked Immunosorbent Assay (ELISA) and the difference in cortisol hormone levels before and after the intervention were analyzed by a paired T-test.

RESULTS:

Honey and propolis honey group decrease cortisol levels but none of the groups have significant changes. This is reciprocal with the changes in the hormone cortisol, the decrease in glucocorticoid hormone levels in the group given honey is the highest following propolis honey and the control group. However, changes in glucocorticoid hormones in the honey group were statistically significant.

CONCLUSION:

Our result confirmed that in women who experience mild stress, honey and honey propolis have the potential to reduce stress-related hormones, that is glucocorticoids and cortisol, this reduction does not have the potential to suppress the immune system.

Thursday, September 12, 2019

Medical Grade Honey May Help Treat Vaginal Yeast Infections (vulvovaginal candidiasis)


Sweet Relief: Determining the Antimicrobial Activity of Medical Grade Honey Against Vaginal Isolates of Candida albicans

J Fungi (Basel). 2019 Sep 9;5(3). pii: E85

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Recurrent vulvovaginal candidiasis (RVVC) is predicted to increase to almost 158 million cases annually by 2030. Extensive self-diagnosis and easily accessible over-the-counter (OTC) fungistatic drugs contribute to antifungal-resistance, illustrating the need for novel therapies.

Honey possesses multiple antimicrobial mechanisms, and there is no antimicrobial resistance towards honey reported. We evaluated the susceptibility of five clinical isolates of Candida albicans and a control strain to regular honey and a medical grade honey (MGH) gel formulation (L-Mesitran, containing 40% honey and vitamins C and E) using an adapted version of the EUCAST protocol at pH 5.2, 4.6, and 4.0. 40% regular honey did not kill or inhibit C. albicans.

In contrast, the minimal inhibitory concentration (MIC) of L-Mesitran was 25%-50%, while fungicidal effects occurred at a 50% concentration (MBC) of the MGH formulation, except for one strain which was not killed at pH 4.0. Overall, pH had little effect on antimicrobial activity. MGH formulation L-Mesitran has antimicrobial activity against C. albicans over a relevant pH range. The vitamin supplements or other components of L-Mesitran may enhance the antifungal activity of the honey.

This study supports performing clinical trials for conditions, such as RVVC, to find an alternative to available OTC fungistatic drugs.

Wednesday, September 11, 2019

Man whose penis ‘split’ has it reconstructed with HONEY – and he can now have sex again

The Sun

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...But during an examination it was revealed that the unnamed man was circumcised, according to an article published in the International Journal of Surgery Case Reports.

Medics at Zealand University Hospital discovered the patient had non-cancerous tumours at the root, shaft and tip of his penis, which were infected.

The growths were causing the skin to split - known as penile denudation.

Medics removed the tumours and attempted to reconstruct his member with skin grafts, but the procedure was unsuccessful.

Un-bee-lievable
They then decided to try Manuka honey, renowned for its anti-bacterial, anti-inflammatory and healing properties, the docs said.

Incredibly, the honey dressings had a "satisfying result" and after two weeks healthy tissue had started to fill the wound...

Monday, September 09, 2019

Wedderspoon Debuts New Bee Propolis Throat Spray Line

Wedderspoon Debuts New Bee Propolis Throat Spray Line with Monofloral Manuka Honey at Natural Products Expo East 2019

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MALVERN, Pa.--(BUSINESS WIRE)-- U.S. Leader of Genuine Manuka Honey Unveils Unique Functional Format Combining the Power of Propolis and Manuka to Soothe and Promote Oral Health

Wedderspoon, passionate steward of authentic Manuka Honey-based products and the #1 selling Manuka Honey brand in the U.S., will debut a new line of functional wellness products, Bee Propolis Throat Sprays with Monofloral Manuka Honey, at Natural Products Expo East Sept. 11-14.

Consumers can seek relief with just three sprays of the Bee Propolis Sprays to help soothe throats and support their immune systems. This new line is available in three flavor offerings including Warming Orange Spice, Cooling Chamomile Mint, and Lemon Ginger. Attendees of Natural Products Expo East are invited to booth #1032 to be the first to see the brand’s newest Manuka Honey innovations...

Saturday, September 07, 2019

Royal Jelly Helps Treat Symptoms of Menopause (Hot Flashes, Aging, Ageing, Fatigue, Night Sweats, Osteoporosis, Insomnia, Anxiety, Irritability, Moodiness, Reduced Sex Drive, Vaginal Dryness)

Could royal jelly be an alternative to HRT? Researchers find the expensive honey bee secretion can help alleviate hot flushes and irritability

It’s a creamy substance bottled up and sold alongside claims it can fight ageing
A study now suggests royal jelly could also combat symptoms of the menopause
It was four times more effective at combating hot flushes as placebos, it found
It comes after a bombshell Oxford study last week linked HRT to breast cancer

By STEPHEN MATTHEWS HEALTH EDITOR FOR MAILONLINE 

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It’s a creamy substance bottled up and sold in health food stores alongside bold claims it can boost your sex drive and fight ageing.

But research now suggests royal jelly – secreted by honey bees to feed their queen – could also be used to combat symptoms of the menopause.

Scientists found taking 'bee milk' daily was four times more effective at combating hot flushes as placebos in women going through ‘the change’.

It comes after a bombshell study last week linked HRT – often dished out to alleviate symptoms in menopausal women – to breast cancer...

Friday, September 06, 2019

Honey May Help Treat Malaria, Giardia, Amoebic Dysentery (Gastroenteritis, Diarrhea, Parasites)


In vitro activity of some natural honeys against Entamoeba histolytica and Giardia lamblia trophozoites

Saudi J Biol Sci. 2019 Feb;26(2):238-243

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Considering the potentiality of honey in combating diseases, the present study was carried out aiming to assess the in vitro antiprotozoal activity of several honeys (Ziziphus spina-christi, Acacia nilotica, Acacia seyal, and Cucurbita maxima) against Entamoeba histolytica and Giardia lamblia by employing the sub-culture method.

All the tested honeys inhibited the growth of trophozoites, and the level of inhibition varied according to the assayed concentrations and incubation times. Acacia seyal honey had completely stopped motility of E. histolytica trophozoites at a concentration ≤ 50 µg/ml after incubation for 72 h. Ziziphus spina-christi, Acacia seyal, and Acacia nilotica honeys had completely inhibited the growth of Giardia lamblia trophozoites at concentration ≤ 200 µg/ml after 72 h.

These inhibitory activities were similar to that of Metronidazole™ which showed IC50  = 0.27. The mammalian cytotoxicity of these honeys against normal Vero cell line which determined by applying MTT method verified the nontoxicity of the examined honeys. Also the proximate composition of the samples indicated compliance with the natural honey standards.

The findings of the study indicate the need for in vivo studies and further investigations to identify active principles with antiprotozoal activities from natural honeys.

Wednesday, September 04, 2019

Brazilian Propolis May Help Treat Colitis (Irritable Bowel Syndrome [IBS], Inflammatory Bowel Disease [IBD], Crohn's Disease, Ulcerative Colitis)


Brazilian propolis extract reduces intestinal barrier defects and inflammation in a colitic mouse model

Nutr Res. 2019 Jul 30;69:30-41

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Brazilian propolis is rich in cinnamic acid derivatives and reportedly reduces intestinal inflammation in rodents; however, the underlying mechanisms remain unclear. We hypothesized that the regulation of tight junction (TJ) barrier, Th17 cell differentiation, and/or, macrophage activation by cinnamic acid derivatives were involved in the propolis-mediated anti-inflammatory effect.

Mice were orally administered 2% dextran sodium sulfate (DSS) in combination with either the feeding control or a diet containing 0.3% ethanol extract of Brazilian propolis for 9 days.

DSS administration induced acute colitis in mice, whereas the propolis extract mitigated DSS-induced weight loss; colon shortening; increased plasma levels of lipopolysaccharide-binding protein; reduced expression of TJ proteins, such as zonula occludens, junctional adhesion molecule-A, occludin, and claudins; and increased expression of inflammatory cytokines, such as tumor necrosis factor (TNF) α, interleukin (IL) 6, and IL-17a. Cinnamic acid derivatives, such as artepillin C and caffeic acid phenethyl ester, present in the propolis extract suppressed the IL-17 production from cultured murine splenocytes through decreased retinoic acid-related orphan receptor gT expression. Baccharin, drupanin, and culifolin, which are also present in Brazilian propolis, reduced the TNF-α and/or IL-6 production by suppressing inflammatory signaling in murine RAW 264.7 macrophages.

Taken together, the regulation of Th17 differentiation and macrophage activation by cinnamic acid derivatives, at least in part, contribute to the anti-inflammatory effect mediated by Brazilian propolis.

Monday, September 02, 2019

Royal Jelly Helps Treat Limb-Threatening Diabetic Foot Wounds


Efficacy of a new local limb salvage treatment for limb-threatening diabetic foot wounds - a randomized controlled study

Dove Press

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Background: Diabetic foot ulcer (DFU) is the main risk factor for nontraumatic lower-limb amputation. We hypothesized that by reversing the offending local tissue factors resulting from the low tissue supply of oxygen, inefficient fuel metabolism and acidosis, we can eradicate the infection and help to promote healing. This might be enhanced with the help of an innovated local preparation (PEDYPHAR®,) through its enriched alkaline ointment base and the regenerating growth factors of Royal Jelly (RJ) plus the antimicrobial, immune-modulatory nutritional and other biochemical properties of RJ and Panthenol. We conducted this study to test the safety and efficacy of PEDYPHAR ointment as an adjuvant in limb salvage management for patients with limb-threatening diabetic foot wounds.

Methods: A prospective, randomized, controlled open-label study design with a mean follow-up period of 12 weeks. One hundred and nineteen eligible patients with diabetic foot wounds presenting to 3 outpatient clinics in Egypt were randomized to be treated with the local application of either PEDYPHAR or Panthenol ointment under dressing after conservative debridement of necrotic tissue and irrigation with warm normal saline.

Results: At the end of the 12-week follow-up period, PEDYPHAR showed a higher rate of complete healing of limb-threatening wounds in the intent-to-treat population, 11 of 34 (32.4%) in PEDYPHAR-treated group versus 3/25 (12%) in the Panthenol-treated (control) group (p = 0.034* [*indicates it is statistically significant]).

Conclusion: We can conclude that PEDYPHAR could be an effective and safe conservative local adjuvant treatment for cases of diabetic foot infection.

Friday, August 30, 2019

Brazilian Red Propolis Varnish Helps Prevent Tooth Decay (Cavities)

Dose-response evaluation of propolis dental varnish in children: A randomized study.

Recent Pat Biotechnol. 2019 Aug 26

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OBJECTIVE:

The objective of this study was to evaluate the dose-response concentration of alcoholic extract of Brazilian red propolis (BRP), in the form of dental varnish, against Streptococcus mutans (S. mutans) in children.

METHODOLOGY:

Twenty-four children, aged between 36 and 71 months, of both genders and without caries, were selected to participate in this pilot study and grouped randomly into four groups to receive different concentrations of BRP varnish (1%, 2.5%, 5% and 10%). The varnish was applied to the surface of all second deciduous molars. The antimicrobial activity was observed in saliva, which was collected in two phases: Before applying the BRP varnish and after use.

RESULTS:

There was microbiological reduction of S. mutans in the oral cavity of the children in all the tested concentrations. The highest percentage reduction of S. mutans was observed at the concentration of 2.5% (P = 0.0443).

CONCLUSION:

The BRP extract in the form of dental varnish has antimicrobial activity against S. mutans and constitutes a possible alternative in the prevention of dental caries.

Wednesday, August 28, 2019

Malaysian Tualang Honey Improves Quality of Life for HIV Positive Patients (AIDS)


Tualang honey ameliorates viral load, CD4 counts and improves quality of life in asymptomatic human immunodeficiency virus infected patients

J Tradit Complement Med. 2018 Sep 28;9(4):249-256. doi: 10.1016/j.jtcme.2018.05.003. eCollection 2019 Oct.

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This is the first study to report on the effects of honey in asymptomatic HIV positive subjects in ameliorating CD4 count, viral load (VL) and quality of life (QOL). It is a randomized, controlled, open labelled study, comparing the effects of Tualang honey (TH) administration for six months at three different doses: 20 g (THL), 40 g (THI) or 60 g (THH) daily compared with control (no administered treatment, THC).

Only asymptomatic HIV positive subjects (n = 95) having CD4 count 250-600 cell/ml, not on antiretrovirals were enrolled. Blood, (together with QOL questionnaires administration) were investigated at baseline, three and six months (CD4 cell count) while VL was determined only at baseline and six months. Significant reductions in CD4 counts in THL and THC groups (p = 0.003 for both) were seen with no significant reductions in the CD4 counts in THI and THH groups (p = 0.447 and 0.053 respectively). There was improvement in VL in THC and THI (130% and 32% respectively) and reductions in THL and THH (26% and 8% respectively). Within and between group analyses for VL indicated significant differences between THL and THH compared to THC.

In addition, significant improvement in QOL of groups which received TH was noted. TH has the potential to improve the QOL (physical and psychological) and CD4 counts. There was a trend of lower VL in asymptomatic HIV subjects following TH administration thus supporting the possible role of TH in boosting the immune system by improving CD4 counts, causing VL reductions in HIV positive subjects.

Monday, August 26, 2019

Propolis Supplementation Improves Immune response


Propolis supplementation improved productivity, oxidative status, and immune response of Barki ewes and lambs

Vet World. 2019 Jun;12(6):834-843

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Aim:

The present study was conducted to study the effect of propolis administration on bio-hematological parameters, antioxidant enzyme activities, and productivity of Barki ewes during late pregnancy and lactation under the arid conditions.

Materials and Methods:

Twenty-five pregnant Barki ewes were fed the basal diet (n = 12, control) and the basal diet plus propolis (5 g/kg diet, n = 13) for 1 month before parturition and continued 2 months after parturition. Milk yield and milk composition, hematological constituents, antioxidant enzyme activities, thyroid hormones, and lambs birth and weaning weights, and antioxidants were determined.

Results:

Significant (p < 0.05) increase in white blood cells in the propolis group compared to control was observed. Mean corpuscular hemoglobin (Hb) (MCH) and corpuscular Hb (MCH concentration %) were decreased (p < 0.05) in propolis compared to control group. Milk yield was increased (p < 0.05) in the propolis group compared with control and continued to increase with the advancement of lactation. Milk fat and milk total solids increased (p < 0.05) in the propolis group than the control. Plasma immunoglobulin A (IgA) was increased (p < 0.05) in propolis compared to control with no effect in IgM and IgG. Superoxide dismutase, hydrogen peroxide (HP), and nitric oxide were decreased (p < 0.01) in the propolis group compared to control. Weaning weight for lambs born to ewes fed propolis was increased (p < 0.05) at week 8 after birth compared with control lambs. Malondialdehyde and HP activities were decreased (p < 0.01) in lambs born to propolis ewes compared to control.

Conclusion:

Crude Chinese propolis (5 g/d) supplementation improved milk yield, milk composition, and the antioxidant enzymes in Barki ewes and immune functions, growth performance and antioxidant status in their lambs under arid conditions.

Sunday, August 25, 2019

Pollen Extracts May Help Treat Benign Prostatic Hyperplasia (BPH) and Chronic Prostatitis (CP) - (Enlarged Prostate, Bladder, Urinary Tract, Kidney)


Therapeutic efficacy of orally administered pollen for nonallergic diseases: An umbrella review.

Phytother Res. 2019 Aug 21

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Pollen has been used for centuries as a tonic and a multipurpose remedy in traditional medicine. The present umbrella review aims to qualitatively assess the therapeutic efficacy of orally administered pollen in the management of nonallergic diseases.

MEDLINE via PubMed, Embase, Scopus, Web of Science, CINAHL, Cochrane Library, and Google Scholar were systematically searched for relevant systematic reviews and meta-analyses. Articles were independently screened and selected, then quality of evidence of included studies was evaluated with a dedicated NIH tool. Retrieved evidence was critically appraised and discussed. Two hundred four articles were found and, after selection process, five systematic reviews were included in the present work, including one with a meta-analysis.

Evidence from these reviews supports the use of grass pollen extracts for symptomatic benign prostatic hyperplasia (BPH) and chronic prostatitis (CP). Additional preliminary evidence on the topic indicates the potential use of grass pollen extracts for vasomotor symptoms in women. Overall, results of the present review suggest that flower pollen extracts may be useful as a complementary remedy for the management of BPH, CP, and vasomotor symptoms. Evidence regarding bee pollen is too limited to draw any conclusion on its clinical efficacy. Further studies are needed.

Saturday, August 24, 2019

Asian Giant Honey Bee Honey May Help Treat Osteoporosis (Ageing, Aging, Old, Elderly, Bones, Diagnosis, Treatment)


Protective effects of honey by bees (Apis dorsata) on decreased cortical thickness and bone impact strength of ovariohysterectomized rats as models for menopause

Vet World. 2019 Jun;12(6):868-876

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Aim:

This study aimed to determine the potential of honey as anti-osteoporosis by evaluating its effectiveness in increasing bone impact strength and cortical thickness, through scanning electron microscopy (SEM) examination.

Materials and Methods:

Forty-five female rats at 3 months of age, weighing 150-200 g were used in the study. They were placed in individual cages and adapted to food and environment for 10 days. On the 11th day, after the animals were adapted for 10 days, the animals were randomly divided into five treatment groups (n = 9): Sham operation group (SH); ovariohysterectomized (OVX) group with no treatment; OVX with treatment Apis dorsata 1 g/kg BW (AD-1); OVX with treatment A. dorsata 2 g/kg BW (AD-2); and OVX with treatment A. dorsata 4 g/kg BW (AD-3). Furthermore, those nine rats in each treatment group were divided into three groups. Three of them were observed at months 1st, 2nd, and 3rd so that in each observation taken three rats in each treatment group. At the end of the study, the rats were euthanized and necropsy for taking their second femoral bone, i.e. dexter region for examining their bone impact strength, while the sinister region was used for measure the cortical thickness of the femoral diaphysis and examining their bone microarchitecture using SEM analysis.

Results:

Based on results of the ANOVA test, the cortical thickness measurements of femoral diaphyseal can be seen that from month 1 to month 3 the lowest result was found in the group of rats that were OVX-I. Meanwhile, the highest result was found in the group of rats that were not OVX (SH-III). It was significantly different from the other treatment groups (p < 0.05). The groups of rats were OVX with honey supplementation at doses of 2 g/kg BW had shown an increasing pattern in the cortical bone thickness from month 1 to month 3. Even on the observation of the 3rd month, the cortical bone thickness in the AD-2 (AD-2-III) group was not significantly different (p > 0.05) from that in the group of rats was not OVX in month 1 (SH-I). The results of the bone impact strength measurement from month 1 to month 3 indicated that the groups of rats were OVX without the administration of honey supplements had the lowest value. The highest bone impact strength was found in the group of rats that was not OVX, but not significantly different (p > 0.05) with the groups of rats that were OVX administered honey supplement with a dose of 2 g/kg BW (AD-2) and 4 g/kg BW (AD-3).

Conclusion:

The supplement of honey A. dorsata at doses of 2 g/kg BW in the group of rats was that OVX can inhibit the decreasing of the cortical bone thickness and repair damage in microarchitecture to generate bone impact strength. As a result, bones are not easily broken.

Thursday, August 22, 2019

Honey Helps Treat Eczema


Eczema treatment: A certain sweet tasting natural product could help relieve symptoms

ECZEMA is a general term that relates to a set of chronic skin conditions which is caused by inflammation. The symptoms of the condition have been described as “agonising”. What natural product could help soothe the symptoms?

By JESSICA KNIBBS

Eczema is a condition in which a person’s skin becomes dry, red and itchy. The symptoms are at their worst when a person experiences a flare-up. This often happens as a result of coming into contact with certain irritants that are known to trigger the condition. People can use creams, natural products, and dietary and lifestyle changes to manage or prevent eczema flares. Natural remedies cannot cure eczema, but can help manage the symptoms and prevent future flares.

Honey is a natural antibacterial and anti-inflammatory agent, and people have used it to heal wounds for centuries.

Honey is one of the most appreciated and valued natural products introduced to humankind since ancient times.

Traditionally, honey has been used around the world to treat skin disorders with a microbiological aetiology.

In Ayurvedic medicine, honey is used to treat cuts and wounds, dermatitis, burns, and eczema.

In modern day practice, manuka honey, produced by honey bees feeding on the manuka tree, is applied topically in the treatment of wounds.

A 2016 study looked at honey and how it could help with skin disorders.

The study by Taylor and Francis Online said: “Studies have shown that honeys form around the world can inhibit the growth of a range of dermatologically important microbes.

"Studies suggest that honey is able to modulate immunological parameters related to the skin immune system...

Wednesday, August 21, 2019

New Zealand Propolis May Help Treat Gastric Cancer


Antiproliferative Acylated Glycerols from New Zealand Propolis

J Nat Prod. 2019 Aug 20

Previous work has shown that a number of phenolic components of NZ propolis possess antiproliferative activity against certain human gastrointestinal cancer cell lines.

Here we report on a series of acylglycerols isolated from the nonpolar fraction of propolis resin, which represent further bioactive constituents unrelated to the more usual phenolic compounds generally found in propolis. NZ propolis is sourced from poplar trees, and the acylglycerols have been shown to be present in the leaves and buds of some common poplars. The compounds are a series of monoglycerides containing 3,8-dihydroxy fatty acids, many of which are further acylated with acetic acid residues. The dihydroxy fatty acids are C18 to C24, with the most abundant being C20 and C22.

These acylglycerols were found to have strong antiproliferative activity against three human gastrointestinal cell lines, particularly gastric cancer cell line NCI-N87, where one example shows an IC50 of less than 50 μM.