Thursday, November 20, 2014

The Anti-Inflammatory and Wound Healing Properties of Honey

December 2014, Volume 239, Issue 6, pp 1003-1014
Honey is a natural product produced by bees and has been used for thousands of years as a medicinal agent and dietary supplement. It is known to cure a wide variety of ailments and can be used as a potent anti-inflammatory and wound healing agent. These vital bioactivities of honey are far less well known than its antibacterial, antioxidant, and any other biological activities. Many clinical trials have been reported and revealed that, when honey is applied to wound, there is a decrease in inflammation and will have a soothing effect. There is much evidence for the anti-inflammatory and wound healing effects of honey in terms of publications in modern medical and scientific journals. The exact mechanism of anti-inflammatory activity and wound healing property of honey has yet to be demonstrated. Possibly there are several mechanisms of action. There are also some reports where honey exerts negligible side effects. The article focuses on the components of honey involved in its anti-inflammatory effect, possible mechanism of action, properties of honey responsible for its wound healing activity, and its adverse effects. Overall the review presents the evidence and explanation for the anti-inflammatory and wound healing properties of honey.

Wednesday, November 19, 2014

Manuka Honey Reduces Motility of Bacteria

Manuka honey reduces the motility of Pseudomonas aeruginosa by suppression of flagella-associated genes
J Antimicrob Chemother. 2014 Nov 16. pii: dku448
Manuka honey is a broad-spectrum antimicrobial agent that seems to affect different bacteria in many different ways. It has been shown to be bactericidal against Pseudomonas aeruginosa by destabilizing the cell wall, but we aimed to investigate whether there were further intracellular target sites.
In this study inhibitory effects of manuka honey on P. aeruginosa were investigated using hydrophobicity assays, two-dimensional electrophoresis, quantitative RT-PCR, transmission electron microscopy and motility assays.
Exposure of P. aeruginosa to manuka honey reduced both swarming and swimming motility. Moreover, this was a consequence of de-flagellation of the bacterial cell, which was correlated with decreased expression of the major structural flagellin protein, FliC, and concurrent suppression of flagellin-associated genes, including fliA, fliC, flhF, fleN, fleQ and fleR. The differential expression of the flagellar regulon in the presence of manuka honey was mapped schematically. Flagella are integral to bacterial adhesion, the initiation of infection and biofilm formation, and swarming has been associated with increased virulence.
By limiting motility in vitro, we infer that manuka honey impacts on the virulence of P. aeruginosa. This deduction must now be tested in vivo.

Tuesday, November 18, 2014

Bee Venom May Help Treat Rheumatoid Arthritis (RA)

Bee venom acupuncture for rheumatoid arthritis: a systematic review of randomised clinical trials
BMJ Open, 2014 Nov 7;4(11):e006140
To assess the clinical evidence for bee venom acupuncture (BVA) for rheumatoid arthritis (RA).
Systematic review of randomised controlled trials (RCTs).
We searched 14 databases up to March 2014 without a language restriction.
Patients with RA.
BVA involved injecting purified, diluted BV into acupoints. We included trials on BVA used alone or in combination with a conventional therapy versus the conventional therapy alone.
Morning stiffness, pain and joint swelling
Erythrocyte sedimentation rate (ESR), C reactive protein (CRP), rheumatoid factor, the number of joints affected by RA and adverse effects likely related to RA.
A total of 304 potentially relevant studies were identified; only one RCT met our inclusion criteria. Compared with placebo, BVA may more effectively improve joint pain, swollen joint counts, tender joint counts, ESR and CRP but was not shown to improve morning stiffness.
There is low-quality evidence, based on one trial, that BVA can significantly reduce pain, morning stiffness, tender joint counts, swollen joint counts and improve the quality of life of patients with RA compared with placebo (normal saline injection) control. However, the number of trials, their quality and the total sample size were too low to draw firm conclusions.

Monday, November 17, 2014

Pine Hone Protects Frozen Sperm Cells

Evaluation of cryoprotective effect of Turkish pine honey on common carp (Cyprinus carpio) spermatozoa

Cryo Letters, 2014 September/October;35(5):427-437


The cryopreservation procedures that allow preserving sperm cells have been applied for sperm of many species. A sugar like glucose, fructose and sucrose were frequently used in cryomedia but up to the present pine honey was not used for cryopreservation of sperm cells.


The objective of present study is to investigate the effect of pine honey in various concentrations of 100, 200, 300, 400 and 500 mg/ml solutions on cryopreservation and fertilization ability of spermatozoa of common carp (Cyprinus carpio).MATERIALS AND METHODS: Totally 12.5 % (v/v) Me2SO as a cryoprotectant and 10 % (v/v) egg yolk added all extenders. Pine honey also compared with sugars as glucose, fructose (monosaccharide) and sucrose (disaccharide). Collected semen samples were diluted at the ratio of 1:9 with the extenders. After dilutions, the sperm motility was assessed for each group and then the diluted semen samples were cryopreserved.


The extenders containing 300 mg ml-1 pine honey group showed both highest post thaw motility 75.3 ± 5.1 %, motility duration (s) 47.3 ± 2.5 % and hatching ratio 42.6 ± 4.2 % than other cryopreserved groups (P < 0.05).


Using the pine honey in cryomedia is effective for cryopreservation especially about hatching success of egg fertilized by frozen-thawed sperm of common carp.

Sunday, November 16, 2014

Anti-Aging Serum with Bee Venom

Bénir Beauty BV-9 Platinum Provectus Super Serum with Bee Venom Review
Truth in Aging, 11/15/2014
Today marks exactly 31 days since I started using Bénir BV-9 Platinum Provectus Super Serum with bee venom ($249). I was anxious to try this serum after reading the ingredients (seven powerful peptides with antioxidants and bee venom), and their claim that, "After 30 days of use, wrinkles and lines look less pronounced, skin is firmer and behaves more youthfully…

Saturday, November 15, 2014

Health from the hive: propolis as an adjuvant in the treatment of chronic periodontitis - a clinicomicrobiologic study

J Clin Diagn Res. 2014 Sep;8(9):ZC41-4
This study was aimed at the clinical and microbiological evaluation of the efficacy of subgingivally delivered Indian propolis extract as an adjunct to scaling and root planing (SRP) in the treatment of periodontitis.
Twenty patients diagnosed with chronic periodontitis presenting a minimum of two pockets (probing depth ≥5 mm) were selected. Sites were assigned randomly into control sites (n=20) which received SRP alone or test sites (n=20) which received SRP and locally delivered propolis. At selected sites, the clinical parameters were assessed and subgingival plaque samples were collected at baseline, 15 days and one month. The samples were cultured anerobically for periodontal pathogens.
The results indicated that there was a significant improvement in both clinical and microbiological parameters (p < 0.01) in the test sites compared to the control sites at the end of the study.
Subgingival delivery of propolis showed promising results as an adjunct to SRP in patients with chronic periodontitis when assessed by clinical and microbiological parameters.

Friday, November 14, 2014

Effectiveness of Propolis on Oral Health: A Meta-Analysis

J Nurs Res. 2014 Dec;22(4):221-9
The use of propolis mouth rinse or gel as a supplementary intervention has increased during the last decade in Taiwan. However, the effect of propolis on oral health is not well understood.
The purpose of this meta-analysis was to present the best available evidence regarding the effects of propolis use on oral health, including oral infection, dental plaque, and stomatitis.
Researchers searched seven electronic databases for relevant articles published between 1969 and 2012. Data were collected using inclusion and exclusion criteria. The Joanna Briggs Institute Meta Analysis of Statistics Assessment and Review Instrument was used to evaluate the quality of the identified articles.
Eight trials published from 1997 to 2011 with 194 participants had extractable data. The result of the meta-analysis indicated that, although propolis had an effect on reducing dental plaque, this effect was not statistically significant. The results were not statistically significant for oral infection or stomatitis.
Although there are a number of promising indications, in view of the limited number and quality of studies and the variation in results among studies, this review highlights the need for additional well-designed trials to draw conclusions that are more robust.

Wednesday, November 12, 2014

Honey: A Potential Therapeutic Agent for Managing Diabetic Wounds

Diabetic wounds are unlike typical wounds in that they are slower to heal, making treatment with conventional topical medications an uphill process. Among several different alternative therapies, honey is an effective choice because it provides comparatively rapid wound healing. Although honey has been used as an alternative medicine for wound healing since ancient times, the application of honey to diabetic wounds has only recently been revived. Because honey has some unique natural features as a wound healer, it works even more effectively on diabetic wounds than on normal wounds. In addition, honey is known as an "all in one" remedy for diabetic wound healing because it can combat many microorganisms that are involved in the wound process and because it possesses antioxidant activity and controls inflammation.
In this review, the potential role of honey's antibacterial activity on diabetic wound-related microorganisms and honey's clinical effectiveness in treating diabetic wounds based on the most recent studies is described. Additionally, ways in which honey can be used as a safer, faster, and effective healing agent for diabetic wounds in comparison with other synthetic medications in terms of microbial resistance and treatment costs are also described to support its traditional claims.

Tuesday, November 11, 2014

New Zealand Firm Comvita Moves to Secure Manuka Honey Supply

NBR, 11/10/2104
Comvita, which produces health products derived from manuka honey, has entered into a joint venture with East Taupo Lands Trust to harvest manuka honey, securing the supply of its main ingredient.
The joint venture Kaimanawa Honey GP will initially start with 3,000 hives to harvest manuka honey on Ngati Tūwharetoa trust's land holdings, the Te Puke-based company said in a statement. Comvita will provide the beekeeping equipment and management systems while East Taupo Lands Trust will lease the land to the joint venture.
“It is not so long ago that manuka trees on Maori land blocks were being cut down for firewood," said  East Taupo Lands Trust chairman Jim Maniapoto. "Today we recognise the value of manuka and the initiatives offered by Comvita…

Monday, November 10, 2014

Bee Venom Therapy Helps Treat Adhesive Capsulitis

Long-Term Effectiveness of Bee Venom Acupuncture and Physiotherapy in the Treatment of Adhesive Capsulitis: A One-Year Follow-Up Analysis of a Previous Randomized Controlled Trial
Objective: An earlier randomized controlled trial (RCT) study showed that bee venom acupuncture (BVA) in combination with physiotherapy can be more effective in functional improvement and pain reduction in patients with adhesive capsulitis (AC). The objective of the current study was to examine the long-term effect of BVA in combination with physiotherapy on AC of the shoulder.
Design: Retrospective 1-year follow-up analysis of a previous RCT using a telephone interview method.
Setting: Outpatient joint center at the Gang Dong Kyung Hee University Hospital of Seoul, Republic of Korea.
Patients: A total of 192 patients had been enrolled in the previous study, and 124 of these were excluded from the current study. Sixty-eight patients who had been treated with combined BVA and physiotherapy for AC of the shoulder for 2 months were interviewed at approximately 1 year after treatment by telephone.
Intervention: Sixty of 68 patients were included in the follow-up analysis. Twenty received BV 1 treatment (1:10,000 concentration BVA plus physiotherapy), 22 received BV 2 treatment (1:30,000 concentration BVA plus physiotherapy), and 18 received control treatment (normal saline injection plus physiotherapy).
Outcome measures: The primary outcome measure was Shoulder Pain And Disability Index (SPADI) score. Secondary outcome measure was score on verbal rating scale for pain and patient satisfaction.
Results: Baseline characteristics of the groups did not significantly differ. SPADI scores at 1 year significantly differed between the BV 1 group and the control group (p=0.043). No significant differences were found in pain verbal rating scores after 1 year. Treatment satisfaction with therapy was also assessed, and the BV 1 and BV 2 groups showed significantly greater satisfaction compared with the control group.
Conclusions: BVA combined with physiotherapy remains clinically effective 1 year after treatment and may help improve long-term quality of life in patients with AC of the shoulder.

Sunday, November 09, 2014

Honey Reduces Pain

The antinociceptive effects of tualang honey in male sprague-dawley rats: a preliminary study
J Tradit Complement Med. 2014 Oct;4(4):298-302
Tualang honey ( Fēng Mì) is known to have anti-inflammatory property, but its antinociceptive property has not been extensively investigated.
In this study, we examined the preemptive effects on administering different doses of Tualang honey and prednisolone on the nociceptive response in male Sprague-Dawley rats. Thirty-five male Sprague-Dawley rats were randomized into five groups (n = 7) and each group received either distilled water, Tualang honey (0.2, 1.2 or 2.4 g/kg) or prednisolone (10 mg/kg) for 10 days. The response to noxious thermal stimulus was assessed using tail flick test on Day 10. The well-being of the rats was also assessed by monitoring their food intake and body weight. Data were analyzed using one-way Analysis of Variance (ANOVA) with post-hoc Scheffe's test and P value less than 0.05 was considered significant. In tail flick test, the tail flick latency time was significantly higher in the groups that received 1.2 g/kg and 2.4 g/kg of Tualang honey and 10 mg/kg of prednisolone, compared to the control group (P < 0.05). 
There was significant reduction in the total food pellet intake in the groups receiving prednisolone and Tualang honey (1.2 g/kg and 2.4 g/kg) compared to controls; however, the body weight gain was only significantly reduced in the prednisolone group. All the parameters were not significantly affected in the group receiving 0.2 g/kg of Tualang honey.
In conclusion, preemptive administration of Tualang honey (1.2 g/kg and 2.4 g/kg) and prednisolone (10 mg/kg) had reduced the pain responses. The reduced weight gain in the prednisolone group is an unwanted effect due to its metabolic and central actions. Further studies are required to confirm the antinociceptive effects and elucidate the mechanism of antinociceptive action of Tualang honey in the rats.

Saturday, November 08, 2014

Royal Jelly, Bee Pollen Recommended for Mental Health, Allergies

Unsung heroes of supplements
Royal jelly is reserved for the aristocracy in the bee hive. The makeup of royal jelly is mostly water, about 10 percent protein, including small amounts of many different amino acids, and about12 percent simple sugars. It also contains many trace minerals, some enzymes, antibacterial and antibiotic components, pantothenic acid (vitamin B5), vitamin B6 (pyridoxine) and trace amounts of vitamin C. When checking Pub Med hundreds of studies were referenced, (for example go to This one concluded, "Six-month ingestion of Royal Jelly in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects". Putting this in normal language what they are saying is that they found benefits in improving red cell numbers/production, sugar tolerance, mental health and an improvement in natural testosterone production.
Bee Pollen has long been used to reduce allergy to pollen. It has been called a nutrition super-food and described as having beneficial effect on health and beauty and cholesterol (lowers bad, increases good), while enhancing physical activity. Because this is pollen-based be careful of using this if you're prone to allergic reaction. Some people believe the more local the bee pollen, the better effect it will have. This may or may not hold true.

Friday, November 07, 2014

Fresh and Old Propolis Samples Have Similar Qualitative Composition

A Comparison between Characterization and Biological Properties of Brazilian Fresh and Aged Propolis
Volume 2014 (2014), Article ID 257617, 10 pages
Objective. As propolis is a highly valued bee product, we aimed to verify the quality of aged propolis, investigating their phenolic and flavonoid composition, levels of toxic metals, radical scavenging and antimicrobial activities.
Material and Methods. Samples of fresh and aged propolis of six different beekeepers, from the same geographical location, were investigated in terms of their phenolic and flavonoid composition and levels of Pb, Cd, and Cr, as well as radical scavenging and antimicrobial activities.
Results. The two groups of propolis had similar qualitative composition by HPLC-PDA and ESI(-)-MS. Fresh propolis and aged propolis show no differences when average values of extraction yield, flavonoids, EC50, or MIC were compared and both types of propolis showed good antimicrobial activity at low concentrations. Only levels of phenolic compounds were higher in fresh propolis.

Conclusion. The propolis samples considered in this study, aged or fresh, had similar qualitative composition, although they were collected in different periods. Samples only differed in their levels of total phenolic content. Moreover, aged propolis conserves significant radical scavenging and antimicrobial properties. We suggest that aged propolis should not be discarded but explored for alternative applications.

Thursday, November 06, 2014

UK Firm Launches Dressing with Honey to Help Healing

Nottingham Post  |  November 04, 2014
CHART-TOPPER Jessie J uses it to keep her voice polished, Olympian Victoria Pendleton swears by it to stave off a cold, and now manuka honey is being added to wound dressings to prevent infections.
Nottinghamshire-based firm Brightwake has developed a new dressing with the honey which could be used to treat ulcers and wounds on people who have undergone surgery.
Manuka honey is known for its medicinal qualities as it is a natural antiseptic.
The dressing, called Actilite Protect, has a silicone layer to stop it sticking to the patient and will be launched at the Wounds UK Annual Conference in Harrogate next week…

Wednesday, November 05, 2014

Bee Venom Therapy in Bahrain

Creating a buzz over bee sting therapy...
By Raji Unnikrishnan, Gulf Daily News, November 04, 2014
A BAHRAIN-BASED bee lover is going against the grain by using the power of stings to bring relief to others.
Frank Ryde keeps more than 50,000 bees in the garden of his home in Sehla.
This one hive, together with the hundreds more he has back home on his estate in the heartlands of Sri Lanka, provide all Mr Ryde needs for his "apitherapy" - the name given to the use of honey bee products for medicinal purposes.
"Bee sting treatment is the best natural medicine and I don't charge people who come to me seeking for cures using bee stings, as I believe this is a God-gifted talent," he said.
"I apply an ice cube on the area where there is pain for a minute so that it becomes numb and then apply the sting.
"The bee venom spreads and the body creates antibodies, which is actually the medication for such ailments."…