Tuesday, October 16, 2018

Propolis Component May Help Treat Endometriosis


Chrysin leads to cell death in endometriosis by regulation of endoplasmic reticulum stress and cytosolic calcium level

J Cell Physiol. 2018 Oct 9

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Chrysin is a natural compound derived from honey, propolis, or passion flowers and has many functional roles, such as antiinflammatory and antiangiogenesis effects. Although endometriosis is a benign gynecological disease, there is a need to identify the pathology and develop a therapy for endometriosis. Elucidating the biological mechanism of chrysin on endometriosis will improve the understanding of endometriosis.

In this study, we confirmed the apoptotic effects of chrysin in human endometriotic cells using End1/E6E7 (endocervix-derived endometriotic cells) and VK2/E6E7 (vaginal mucosa-derived epithelial endometriotic cells).

The results showed that chrysin suppressed the proliferation of endometriosis and induced programmed cell death through changing the cell cycle proportion and increasing the cytosolic calcium level and generation of reactive oxygen species.

In addition, chrysin activated endoplasmic reticulum (ER) stress by stimulating the unfolded protein response proteins, especially the 78-kDa glucose-regulated protein-PRKR-like ER kinase (PERK)-eukaryotic translation initiation factor 2α (eIF2α) pathway in both endometriotic cell lines.

Furthermore, chrysin inactivated the intracellular phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, also known as AKT) signaling pathway in a dose-dependent manner. Collectively, the results of this study indicated that chrysin induced programmed cell death by activating the ER stress response and inactivating the PI3K signaling pathways in human endometriotic cells.

Monday, October 15, 2018

Honey Shows Antifungal Activity

Italian acacia honey exhibits lytic effects against the crayfish pathogens Aphanomyces astaci and Fusarium avenaceum

Lett Appl Microbiol. 2018 Oct 13

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This study purpose was to evaluate the in vitro inhibitory properties of Italian acacia honey extracts against pathogenic aquatic oomycete/fungal isolates that cause different diseases in crayfish, resulting in an elevated mortality rate.

The antimycotic activity of acacia honey aqueous extracts were evaluated against the strain UEF88662 of Aphanomyces astaci (oomycete) and the strain SMM2 of Fusarium avenaceum (fungus). The extracts preparation was carried out with water by a cheap, not complex and organic solvent-free procedure, with low environmental impact and the higher possibility of large-scale reproducibility. The anti-oomycete and antifungal activities were quantitatively evaluated by growth, survival and sporulation microbiological assays.

The extracts displayed a dose-dependent inhibitory efficacy on oomycete and fungal growth and survival, as well as on the production of oomycete and fungal spores. Supported by future in vivo studies, our results encourage the use of natural extracts like honey as innovative tools to counteract mycotic infections.

Saturday, October 13, 2018

Propolis Used to Treat Enlarged Prostate, Dandruff, Acne, Nail Fungus, Toothache, Ear Infections, Gastritis, Chronic Rhinitis

BEES-WORKERS TO NO END PRODUCE IT! FEW PEOPLE KNOW HOW TO TAKE…

October 13, 2018

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Бджоли-робітниці без кінця виробляють його! Мало хто знає, як правильно приймати… 

Propolis is a dark resinous substance produced by bees to glossing over cracks and isolation from foreign objects in the hive. Its other name is bee glue, in ancient times it was called the UGA, bee balm bee or plaster.

Bee glue has very strong antimicrobial properties. Thanks to the propolis the bees in the hive is always clean and pristine. Using propolis, bees mummified any insect or animal, such as a mouse, which they can’t get out of his nest, thus preventing rotting and decay.

THE PROPERTIES OF TINCTURE OF PROPOLIS

Due to its unique properties propolis is able to cope with many internal and external diseases. However, to achieve a positive effect, it must apply correctly. Dry propolis is used quite rarely, most often treatment is with the help of his tinctures.

In late February, I began to treat a sore throat, which worried me, no matter what medications I tried. A friend advised me to take tincture of propolis. I really was hoping for a quick result, but after a couple of days of bothersome pain in the throat disappeared.

Tincture of propolis once again proved its effectiveness, and I was curious to know what kind of healing properties it possesses. I already own the experience felt, how she copes with the cold, but how else can I use it?

THE USE OF TINCTURE OF PROPOLIS IN VARIOUS DISEASES

With stomatitis

Stomatitis hurts both children and adults. How to get rid of this disease without going to hospital? Really effective treatment — tincture of propolis.

Help with stomatitis rinse the mouth alcohol tincture of propolis. To start razbaby drug. In 1 Cup of warm liquid (milk, water) you need to add 15-20 grams of solution. Do rinse recommend about 1 month. Alcohol tincture is also used in the form of lotions.

Gastritis

Propolis for gastritis helps to relieve inflammation and pain. Thus it can be used with any acidity, including increased.Treatment of gastritis propolis involves strict control of the doctor and several different regimens, which ideally can be individualized after a complete diagnosis.

Chronic gastritis can be treated with 20% alcohol tincture. For this purpose it is necessary to take 40 drops three times per day. Drinking the extract of bee glue takes about two weeks. This assignment to do in normal and high acidity.

For toothache

Teeth and gums is generally a sore subject, and when they get sick, want to climb the wall. But if you have propolis, to relieve pain and make your mouth healthier can be a few procedures.Propolis not just temporarily relieves pain, eliminates unpleasant process, prevents the bacteria to continue the destructive influence to tissues of the tooth.

Rinse your mouth with tincture of propolis for tooth pain 3-4 times a day. So you will remove the inflammation of the gums, destroyed a fair amount of harmful bacteria that will get rid of the pain.

For otitis

For otitis media can be instilled 2 drops of the tincture in each ear to relieve inflammation. When purulent inflammation of the middle ear it is necessary to prepare the cords of the bandage, moisten the cloth in the tincture and insert in the ear for 20 minutes, pre gently clearing the ear pus.


In acute or chronic rhinitis

The mucosa of the nasopharynx — a hotbed of pathogenic microorganisms, which increase the symptoms of disease and weaken the immune system. To accelerate the treatment of chronic rhinitis, nasal wash salt solution with tincture of propolis.1 glass of water, take half a teaspoon of salt and half a teaspoon of tincture of propolis. Rinse nose best using special tools (available at pharmacies). You can use a small teapot infuser.

Got up the spout of the pot into your right nostril, tilt your head to the left, the water should be poured through the left nostril. Then do the same thing, washing the left side...

Friday, October 12, 2018

Bee Venom Helps Treat Atopic Dermatitis (Eczema)

Use of Bee Venom for Topical Treatment in Patients With Atopic Dermatitis

Dermatology Advisor

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The use of bee venom (BV) and its major component, melittin, has proven suitable as an epicutaneous application for the treatment of atopic dermatitis (AD), according to the results of an in vivo and in vitro study conducted in an AD-like model, with findings published in the British Journal of Pharmacology.

The investigators sought to explore the potential pharmacologic effects of bee venom and melittin on 1-chloro-2,4-dinitrobenzene (DNCB)-induced in vivo and tumor necrosis factor-alpha (TNF-α)/tumor necrosis factor-gamma (TNF-γ) in vitro AD-like models of skin disease.

Study results showed that bee venom and melittin possess potent anti-atopic activities, as demonstrated by decreased DNCB-induced AD-like skin lesions in an animal model. In vitro studies that used TNF-α/ TNF-γ–stimulated human keratinocytes revealed that bee venom and melittin inhibit the exaggerated expression of such chemokines as TARC/CCL17 and MDC/CCL22, as well as such pro-inflammatory cytokines as interleukin-1-beta (IL-1β), IL-6, and interferon (IFN)-γ, via blockade of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and signal transducers and activators of transcription (STAT) pathways.

The investigators concluded that since the use of topical agents is often recommended for the treatment of AD, bee venom and melittin are suitable for epicutaneous application. The results of this study showed the ameliorating effects of bee venom and melittin on the DNBC-induced AD-like skin lesions in BALB/c mice and TNF-α/ TNF-γ–stimulated human keratinocyte HaCaT cells.

By suppressing production of Th1/Th2–associated and pro-inflammatory cytokines, bee venom and melittin decreased inflammatory symptoms in AD-like skin lesions, resulting in a subsequent reduction in CD4+ T cells, mast cell infiltration, and release of serum immunoglobulin E (IgE). Moreover, bee venom and melittin improved abnormal epidermal differentiation by restoration of filaggrin expression.

'Mad Honey' Heals Infected Wounds

The effect of different types of honey on healing infected wounds

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J Wound Care. 2018 Oct 1;27(Sup10):S18-S25

OBJECTIVE:

To investigate the effects of treatments of 'mad honey', blossom honey and nitrofurazone on infected wound healing.

METHOD:

Male albino Wistar rats were randomly divided into four groups: 'mad honey' (MH), blossom honey (BH), nitrofurazone (N) and control (C). All rats were anaesthetised intraperitoneally. A circular skin incision was made to the back regions. Grafts containing slime-producing Staphylococcus epidermidis were placed on the incision area and then sutured to the skin. Infection in the wound area was confirmed after 48 hours. Wounds were dressed twice daily with the various treatment materials. Rats were randomly euthanised on days 7 or 14, and tissue samples taken. Tissue samples were assessed for hydroxyproline (HP), tensile strength (TS) and macroscopic measurement (area and intensity).

RESULTS:

HP levels were higher in the treatment groups (MH, BH, N) at days 7 and 14 compared with the control group. 'Group x day' interaction was found in the HP levels (p = 0.015). Increases in HP levels in the MH and N groups between days 7 and 14 were significantly higher than those in the other groups (p < 0.05). Intensity was significantly lower in the control group and significantly higher in group MH compared with the other groups. Significant 'group x day' interaction was observed in intensity (p = 0.006). TS was significantly lower on day 7 than on day 14 (p = 0.022). No marked difference was observed between the groups, nor any 'group x day' interaction, in terms of TS.

CONCLUSION:

Honey administration successfully healed infected wounds. However, there was no significant difference between the effect of MH and that of N in terms of wound healing.

Thursday, October 11, 2018

Propolis Accelerates Diabetic Wound Healing


Polysaccharide-based film loaded with vitamin C and propolis: A promising device to accelerate diabetic wound healing

Int J Pharm. 2018 Oct 6. pii: S0378-5173(18)30745-2

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Wound healing can be a painful and time-consuming process in patients with diabetes mellitus. In light of this, the use of wound healing devices could help to accelerate this process. Here, cellulose-based films loaded with vitamin C (VitC) and/or propolis (Prop), two natural compounds with attractive properties were engineered.

The starting materials and the cellulose-based films were characterized in detail. As assessed, vitamin C can be released from the Cel-PVA/VitC and Cel-PVA/VitC/Prop films in a controlled manner. In vitro antibacterial activity studies showed a reduction of bacteria counts (Escherichia coli and Staphylococcus aureus) after Cel-PVA/VitC, Cel-PVA/Prop, and Cel-PVA/VitC/Prop treatments. Moreover, we examined the antibacterial and wound healing properties of the cellulose-based films in a streptozotocin (STZ)-induced diabetic animal model. Diabetic mice exhibited impaired wound healing while the Cel-PVA/VitC/Prop treatment increased the wound closure.

A marked reduction in bacterial counts present in the wound environment of diabetic mice was observed after Cel-PVA/VitC, Cel-PVA/Prop and Cel-PVA/VitC/Prop treatment. Histological analysis demonstrated that the non-treated diabetic mice group did not exhibit adequate wound healing while the treated group with Cel-PVA/VitC and Cel-PVA/VitC/Prop films presented good cicatricial response. Furthermore, these novel eco-friendly films may represent a new therapeutic approach to accelerate diabetic wound healing.

Wednesday, October 10, 2018

6 Ways Manuka Honey Benefits Your Skin, Gut Health, and More (Probiotics, Acne, Wound Healing, Sinus, Diabetes)

Its potent antibacterial properties can treat cuts, calm acne, and bolster probiotics.

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By Maria Masters, Oct 9, 2018

Honey is one of those products that seems to do it all. It can sweeten any meal, hydrate parched skin, and soothe a sore throat when you’re feeling sick—but one particular honey stands out from the rest. Manuka honey, which is native to New Zealand and parts of Australia, has been gaining lots of buzz in the wellness world for its potent healing properties.

While some celebrities (like Kourtney Kardashian) are huge fans of the stuff, it’s also being researched by otolaryngologists, dermatologists, and nutritionists, many of whom are (at least cautiously) optimistic. Curious? Here’s everything you need to know about Manuka honey, its body-wide health benefits, and where to find it if you want to try it out for yourself.

Manuka is a special type of honey that’s made from bees that pollenate the Manuka plant, a shrub or small tree that’s native to New Zealand and eastern Australia. The Manuka flower produces a nectar that has unique compounds that aren’t as concentrated in other types of honey, including methylglyoxal, which is known for its antibacterial properties.

All genuine Manuka honey products have a Unique Manuka Factor (UMF) placed on the label, a trademark that rates the honey to signify the strength and quality of its signature properties, which is determined through independent testing. It’s these various compounds that have been linked to the health benefits of Manuka honey...

Tuesday, October 09, 2018

Bee Venom Can Kill HIV (AIDS)


Bee venom can kill virus, heals wounds faster

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By AbdulAzeez Bello

Dr Mkabwa Manoko of the University of Dar es Salaam, Tanzania, said bee venom could be used to kill deadly viruses in the body.

Dr. Manoko, also Head of the Department of Crop Sciences and Beekeeping Technology in the university, said this in an interview with the News Agency of Nigeria (NAN) on the sidelines of the just concluded ApiExpo Africa in Abuja.

He noted that honey also had a medicinal value that could be used for wound management without side effect.

The don said more studies and research implementation were required to tap into other potentialities of bees.

“Bees produce a lot of products that have industrial use in the pharmaceutical, food and beverage industries.

“Honey has medicinal property. It can be used for wound management, it is cheap, it takes a short time to heal and has no side effect like other chemicals.

“Bees produce propolis, venom, pollen, and all these are  valuable,” Manoko said.

He added that it was clearly established in research that bee venom had the ability to kill HIV, but not human cells. So it is something that research can explore to see how it can be used in the cure of HIV/AIDS....

Monday, October 08, 2018

Propolis Shows Anti-Inflammatory, Antibiotic, Antioxidative, Anticancer, Antifungal, Anesthetic, and Cytostatic Effects

3.3. Propolis

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Propolis or bee glue is a resinous substance that bees collect from various living plants for construction and adaptation of their nests, consisting of three major components: flavonoids, phenolic compounds, and caffeic acid phenethyl ester (CAPE). As a functional food, it has a range of biological activities such as anti-inflammatory, antibiotic, antioxidative, anticancer, antifungal, anesthetic, and cytostatic effects. In Caco-2 cells and in rats, propolis protects intestinal barrier function by increasing expression of tight junction loci occludin and zonula occluden and activating AMP-activated protein kinase and extracellular regulated protein kinase signaling. In intestinal epithelial cells, CAPE, as an active constituent of honeybee propolis, inhibits nuclear factor- (NF-) κB signaling and TNF-induced and IFN-induced protein- (IP-) 10 expression, independently of p38 mitogen-activated protein kinase (MAPK) and HO-1 signaling pathways, revealing its anti-inflammatory effect.

Sunday, October 07, 2018

Flavanones and Flavones from Bashkir Propolis


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Chemistry of Natural Compounds
September 2018, Volume 54, Issue 5, pp 975–977

Propolis is a product of the honey bee Apis mellifera and has a broad spectrum of biological activity (antimicrobial, antifungal, antitumor, antineurodegenerative, anti-inflammatory, antioxidant, cytotoxic, antituberculosis, antiviral, and immunomodulating) that is widely employed in traditional and folk medicine.

Greater than 500 compounds, of which more than 150 were flavonoids, were identified in the constituents of propolis depending on the geographic location, bee species, and plants.

The chemical composition of Bashkir propolis produced by A. mellifera from plants of the southern Urals (Bashkiria) was studied by us for the first time. Pure flavanones 1–4 and flavones 5 and 6 were isolated and identified.

Saturday, October 06, 2018

Propolis Component May Help Treat Brain Cancers Glioblastoma and Melanoma

Two Deadly Brain Cancers May Have Met Their Match

09/27/2018

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Glioblastoma and Melanoma metastasized to the brain are incredibly deadly brain cancers. However, pharmaceutical company Moleculin Biotech, Inc. hopes the diseases have met their match in a small molecule compound known as WP1066.

The company has initiated a Phase 1 clinical trial of the new first-in-class cancer drug candidate discovered by Professor Waldemar Priebe at The University of Texas MD Anderson Cancer Center. In animal models, WP1066 has shown to both inhibit an important cell signaling protein STAT3 that is involved in cell growth and proliferation, and also stimulate an immune response.

The first glioblastoma patient has received the initial doses of the compound at MD Anderson Cancer Center, and is said to have tolerated the dose well.

“Treating the first brain tumor patient with WP1066 is the start of a very exciting and encouraging program for doctors treating the worst types of brain cancers. There has been very little progress in recent years toward improved therapies for glioblastoma and other aggressive primary or metastatic brain tumors.  WP1066 has shown extremely promising results based on animal studies where we have seen inhibition of tumor growth and improvements in survival,” said Dr. Sandra Silberman, an oncologist and Moleculin’s CMO.

WP1066, which is built from the chemical backbone of the active ingredient in propolis, a natural product of honey bees, not only directly kills tumor cells, but also has the ability to overcome the tumor’s ability to evade the natural immune response, which would otherwise be working to eliminate the cancerous activity....

Friday, October 05, 2018

Propolis is a Natural Antibiotic

BEST NATURAL ANTIBIOTICS

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Antibiotics available in pharmacies should be used only in serious situations. Their uncontrolled use enhances the activity of viruses, fungi and bacteria. However, nature provides us with many antibiotics that are found in plants, roots and flowers. Excessive use of different types of synthetic antibiotics, offered through the pharmacological industry, eventually led to the fact that bacteria and viruses are becoming more resistant to chemicals used against them. Most of us are accustomed to use them in almost all cases, regardless of the scale of the problem. In the case of viral infections antibiotics don’t work.

Their excessive use of harmful bacterial intestinal flora. Therefore, synthetic antibiotics kill the good bacteria that leads to a significant reduction of resistance to all types of infections and diseases. Magicforum found out than you can replace these antibiotics.

Meanwhile, in nature there is a sufficiently large group of so-called natural antibiotics, which not only strengthen the immune system and help cure bacterial infections, but do that without compromising our health. Natural antibiotics contained in many foods and plants, and is an excellent alternative that allows us to take care of health.

Natural antibiotics...

6. Propolis

Propolis serves the bees to strengthen the hive, seals the nest and provides samesite from germs. In its composition it contains about 300 medicinal ingredients. Propolis has a strong antibacterial properties with a wide spectrum of action. It helps in the treatment of infections, gingivitis and periodontitis. It can also be used to treat eczema, boils, and diseases of the gastrointestinal tract. Ideal for strengthening the immune system.

Recipe for propolis tincture: 50 g propolis pour in a quarter of alcohol. Aged for 14 days in a tightly closed container in a cool, dark place, shaking occasionally, 2-3 times a day. Then remove the dark brown liquid from the sludge. Keep tincture in a dark glass bottle. Do not discard the sediment! You can use it to compress with the articular and rheumatic pains...

Thursday, October 04, 2018

Health Benefits of Bee Pollen Enhanced by Fermentation with Kombucha


Bee Collected Pollen with Enhanced Health Benefits, Produced by Fermentation with a Kombucha Consortium

Nutrients 2018, 10(10), 1365

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The bioavailability of pollen bioactive compounds for humans is limited. In this study, our aim was to enhance the health-related benefits of pollen by fermentation with a Kombucha/SCOBY (symbiotic culture of bacteria and yeasts) consortium.

We performed the fermentation of pollen suspended from the beginning with SCOBY on sweetened green tea or on Kombucha vinegar, by adding pollen after 20 days of Kombucha fermentation. We analyzed: formation of bioactive compounds (anti-oxidant polyphenols, soluble silicon, hydroxy-acids, short chain fatty acids—SCFA); parameters related to Kombucha fermentation (dynamics of lactic acid bacteria—LAB, formation of organic acids, soluble sugar evolution on Kombucha vinegar); the influence of Kombucha fermentation on pollen morphology and ultrastructure; in vitro cytotoxic and antitumoral effects of the Kombucha fermented pollen.

The pollen addition increases LAB proportion in the total number of SCOBY microbial strains. SEM images highlight the adhesion of the SCOBY bacteria to pollen. Ultrastructural analysis reveals the release of the pollen content. The content of bioactive compounds (polyphenols, soluble silicon species and SCFA) is higher in the fermented pollen and the product shows a moderate antitumoral effect on Caco-2 cells.

The health benefits of pollen are enhanced by fermentation with a Kombucha consortium.

Wednesday, October 03, 2018

Incorporation of Propolis is a Useful Strategy for Development of Active Packaging with Antioxidant and Antimicrobial Effects

Development of poly(lactic acid) films with propolis as a source of active compounds: Biodegradability, physical, and functional properties

Inc. J. Appl. Polym. Sci. 2018, 135, 47090

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Active films (AFs) using poly(lactic acid) (PLA) as a polymeric matrix containing various propolis concentrations (5, 8.5, and 13%) as the active agent (AA) were developed using a casting method.

The purpose was to determine the effects of the incorporation of AA on the physical properties of the films and to evaluate the antioxidant and antimicrobial activities. Tensile strength and elastic modulus of the AFs decreased relative to the control (PLA without AA). Introducing the active substances from propolis into the PLA also affected its thermal properties (glass transition).

Adding AAs to the polymer generated more opacity with a green‐yellowish color compared to the control. In addition, AFs exhibited reduced water vapor permeability as the AA concentration increased. Biodegradation assay showed that the AFs degraded faster than the control. AFs exhibited antioxidant activity, which was measured as the ability to scavenge free radicals (2,2‐diphenyl‐1‐picrylhydrazyl and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonate)), due to the presence of bioactive compounds (phenolics).

Antimicrobial activity was evaluated against Escherichia coli and showed a reduction over 4‐log cycles.

Therefore, incorporation of propolis is a useful strategy for the development of active packaging with antioxidant and antimicrobial effects, which increase the shelf life of food products.

Tuesday, October 02, 2018

Similarity of Data from Bee Bread with the Same Taxa Collected in India and Romania

Molecules 2018, 23(10), 2491

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Bee Bread samples from Romania and India were analysed by microscopy and High Performance Liquid Chromatography with Diode Array Detection (HPLC/DAD) and compared with pollen from the correspondent taxa.

The quantification of sugars, fructose/glucose ratio, total phenolics and flavonoids was also carried out. From the results was possible to identify Brassica and Eucalyptus samples that present similar HPLC/DAD profiles with the respective ultraviolet (UV) identification of the main compounds as Kaempferol-3-O-glycosides and Hydrocinnamic acid derivatives. The Fructose/Glucose (F/G) ratio and the total amounts of phenolics and flavonoids was in line with the prevalence of the specie identified.

These coincident fingerprints gave the identification of the samples, as was previously proposed for bee pollens. This paper relates for the first time the achievement on the taxon carried out previously only for bee pollens. It was reported for the first time that this phenolic profile remains unchanged in the case of floral pollen (hand collected), bee pollen and bee bread.

Despite the biochemical transformation that occurs during the fermentation of bee bread, it seems that these phenolic compounds are not affected and remain unchanged. Also, variables such as soil and climate do not seem to influence these compounds for the kind of samples under study.