Thursday, February 20, 2020

Medical Grade Honey Boosts Healing of Pediatric Abdominal Wounds

Medical grade honey for the treatment of paediatric abdominal wounds: a case series

J Wound Care. 2020 Feb 2;29(2):94-99

OBJECTIVE:

Children are at high risk of injuries and wounds. The application of medical grade honey is a promising approach to improving the healing of wounds of various origin and severity. However, the use of medical grade honey in young paediatric patients remains limited. The aim of this study is to show the safety, efficacy and usefulness of medical grade honey in abdominal wounds, of different causes, in paediatric patients.

METHOD:

This was a prospective, observational case series evaluating five young infants with abdominal wounds at the General Hospital in Thessaloniki. All wounds were treated in the same manner with daily medical grade honey applied to the wound area and closely monitored.

RESULTS:

All treated wounds rapidly presented granulation tissue formation and underwent re-epithelialisation. Peripheral oedema and inflammation decreased upon initial application. Necrotic tissue was effectively debrided when present. Slough was removed and no signs of infection were detected, irrespective of initial wound presentations. Scar formation was minimal and the full range of motion was preserved in all cases.

CONCLUSION:

Based on this case study, medical grade honey is safe and effective in treating different abdominal wounds, including infected or dehisced wounds as well as burns. The easy application and broad applicability make medical grade honey recommendable as a first-line treatment in paediatric patients.

Thursday, February 13, 2020

Potential Benefits of Propolis for Humans

Green Matters

According to WebMD, some people believe that propolis might be inflammatory, that it can help heal skin, and that it can fight bacteria, viruses, and fungi. As the NCBI review added, propolis (and propolis-derived products) are believed by some to have "antiseptic, anti-inflammatory, antioxidant, antibacterial, antimycotic, antifungal, antiulcer, anticancer, and immunomodulatory" properties...

Tuesday, February 11, 2020

Honey Reduces Postoperative Pain after Tonsillectomy (Tonsillitis)


The effect of adjuvant oral application of honey in the management of postoperative pain after tonsillectomy in adults: A pilot study.

PLoS One. 2020 Feb 10;15(2):e0228481

OBJECTIVE:

To analyze the effect of adjuvant oral application of honey for treating postoperative pain after tonsillectomy.

DESIGN:

Single centre prospective cohort study.

SETTING:

Two cohorts of patients after tonsillectomy.

PARTICIPANTS:

56 patients treated with honey 8 times per day (honey group), 18 patients treated without honey (control group); baseline analgesia were non-steroidal anti-inflammatory drugs (NSAID) or coxibs; opioids were used as pro re nata (PRN) medication; mean age 34.4 ± 13.4 years; 36% women.

MAIN OUTCOME MEASURES:

On first to fifth postoperative day, patients rated their pain using the validated questionnaire of the German-wide project Quality Improvement in Postoperative Pain Treatment (QUIPS) including a numeric rating scale (NRS, 0-10) for determination of patient's pain. QUIPS allows standardized assessment of patients' characteristics andpain-associated patient-reported outcomes (PROs). The influence of preoperative and postoperative parameters on patients' postoperative pain were estimated by univariate and multivariate statistical analysis.

RESULTS:

Average pain in activity in the control group was greater than 4 (NRS 4.4 ± 2.4) during the first five postoperative days, with a renewed increase in pain intensity on the fifth day (4.3 ± 2.5). In the honey group, the pain in activity decreased without any further pain increase and was only higher than 4 on the first three postoperative days (4.3 ± 2.1, all p > 0.05). However; neither minimal nor maximal pain were significantly different between both groups on the first postoperative day (p = 0.217, p = 0.980). Over the five postoperative days, the minimal and maximal pain in the honey group decreased continuously and faster than in the control group. With regard to pain-related impairments on the first day, the honey group reported less pain-related sleep disturbance (p = 0.026), as well as significantly fewer episodes of postoperative oral bleeding (p = 0.028) than the control group. Patients without honey consumption had on the first and fifth postoperative day a higher risk of increased minimal pain (OR = -2.424, CI = -4.075 --0.385). Gender was an independent factor for compliance of honey consumption on the second postoperative day (p = 0.037). Men had a lower probability for compliance of honey consumption (OR = -0.288, CI = -2.863 --0.090).

CONCLUSION:

There was a trend of reduced postoperative pain after oral honey application. Honey also seems to reduce pain-related impairments. The need for additional opioids on the first day could be reduced. A larger controlled trial is now needed to varify the effect of honey on pain after tonsillectomy.

Friday, February 07, 2020

Royal Jelly may Help Treat Alzheimer's Disease (Memory, Aging, Cognition, Cognitive, Neurodegenerative Diseases)


Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in cognitive function. Intracerebroventricular injection of streptozotocin (icv-STZ) has been used as an experimental model of Sporadic AD (SAD) in rodents and represents a promising tool for etiopathogenic analysis and evaluation of new therapeutic proposals for AD.

The icv-STZ model shows many aspects of SAD abnormalities, resulting in decreased brain glucose and energy metabolism, cognitive impairment, oxidative stress, neuronal loss, and amyloid angiopathy. Royal jelly (RJ), a substance produced by worker honeybees of the Apis mellifera species, has been popularly used for more than 30 years in areas related to health eating and natural medicine.

Researches indicate that RJ has a several pharmacological activities, including neuroprotective and improvement of cognitive function. The objective of this study was to investigate the effects of oral treatment with royal jelly during 2 weeks in Wistar rats submitted to icv-STZ on a working memory and neuroprotection, as evaluated by neurogenesis, neurodegeneration and oxidative stress.

In this study, icv-STZ injection induced deleterious effects in the hippocampus, associated with cognitive impairments, and developed marked neurodegeneration, besides the reduction of neurogenesis and increased oxidative stress.

On the other hand, RJ long-term oral administration induced beneficial effects in animals injured by icv-STZ injection, increasing retention time for working spatial memory, reducing neurodegeneration and oxidative stress level and increasing the proliferation of new neurons in the hippocampus. Thus, RJ promotes beneficial effects on cognitive functions and exhibits a neuroprotective action in the STZ experimental model of SAD

Wednesday, February 05, 2020

Honey Equal to Aspirin in Preventing Cardiovascular Disease (CVD), But Without Side Effects (Heart Disease, Mortality, Antiplatelet)


Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice

Open Access Maced J Med Sci. 2019 Oct 14;7(20):3416-3420

BACKGROUND:

The prevalence of cardiovascular disease (CVD) and its mortality continues to increase. Various studies have shown aspirin can reduce CVD mortality but has adverse side effects. Research on a comparison between aspirin and honey has not been done, but both have antiplatelet effects.

AIM:

This study is aimed to prove the antiplatelet effects on honey and compare the antiplatelet effects of aspirin with honey based on the bleeding time in mice.

METHODS:

This study is a true experimental design with a post-test only control group using 32 male mice, Double Ditsch Webster, ± 3 months old, the weight of 20-30 g, divided into 4 groups. Consisting of a negative control group (placebo), aspirin and honey. The suspension has given orally for 12 days using the probe. The research was conducted at the Laboratory of Pharmacology Department of Pharmacology and Therapeutics Faculty of Medicine, the University of North Sumatra in September until December 2015. The data collected was bleeding time in mice. Data analysed by Shapiro Wilk test, Kruskal Wallis and Mann Whitney.

RESULTS:

The mean bleeding time was a placebo (102.88 seconds), aspirin (369.38 seconds) and honey (304.63 seconds). Mann Whitney test showed significant results in the aspirin and honey groups against the control group (placebo) with p = 0.001. There were no significant differences in the aspirin group against honey (p = 0.172). Honey has an antiplatelet effect in mice. The mean bleeding time in mice given honey is longer or closer to the mean bleeding time in the aspirin group.

CONCLUSION:

The results could be used as a basis for further research to determine its use in humans with cardiovascular disease.

Wednesday, January 29, 2020

Is Honey Effective as a Natural Medicine for Cardiovascular Diseases in Humans?

Honey and Its Phenolic Compounds as an Effective Natural Medicine for Cardiovascular Diseases in Humans?

Nutrients. 2020 Jan 21;12(2). pii: E283

Honey is a sweet, viscous syrup produced by the honey bee (Apis mellifera). It is probably the first natural sweetener ever discovered, and is currently used as a nutritious food supplement and medicinal agent. The aim of the present mini-review is to summarize and update the current knowledge regarding the role of honey in CVDs based on various experimental models. It also describes the role of its phenolic compounds in treating CVDs. Many such phenolic and flavonoid compounds, including quercetin, kaempferol, apigenin, and caffeic acid, have antioxidant and anti-platelet potential, and hence may ameliorate cardiovascular diseases (CVDs) through various mechanisms, such as by decreasing oxidative stress and inhibiting blood platelet activation. However, as the phenolic content of a particular type of honey is not always known, it can be difficult to determine whether any observed effects on the human cardiovascular system may be associated with the consumption of honey or its constituents. Therefore, further experiments in this area are needed.

Thursday, January 23, 2020

Successful Treatment of Lymphocytic Colitis With a Honey Lavage

Inflammatory Bowel Diseases

22 January 2020

To the Editors,

Microscopic colitis is a frequent cause of nonbloody chronic watery diarrhea. The diagnosis of microscopic colitis is based upon mucosal biopsy of the colon with specific histologic features in the mucosa. There are 2 subtypes, collagenous colitis and lymphocytic colitis, based on a subepithelial collagen band and increased intraepithelial lymphocytes, respectively. Although its exact etiology is unknown, the disorder is associated with medication such as nonsteroidal anti-inflammatory drugs and proton pump inhibitors and autoimmune disorders such as celiac disease, polyarthritis, and thyroid disorders. The standard therapy for microscopic colitis consists of glucocorticosteroids, antidiarrheals, and cholestyramine. Although these treatments often cause cessation of symptoms, relapses are seen...

Tuesday, January 21, 2020

Stingless Bee (Kelulut) Honey Reduces Anxiety, Improves Memory

Stingless bee honey reduces anxiety and improves memory of the metabolic disease-induced rats

CNS Neurol Disord Drug Targets. 2020 Jan 16

BACKGROUND:

Evidence suggested the involvement of metabolic syndrome (MetS) in the progression of neurodegenerative diseases through oxidative stress. Consumption of antioxidant compounds was found to be beneficial on brain-health by reducing brain oxidative stress level and improve cognitive performance in animal. Stingless bee honey or locally known as Kelulut honey (KH) exert high phenolic content and widely used as food supplement.

OBJECTIVES:

In this study, we aim investigate the effects of KH on the brain of MetS-induced rats.

METHOD:

Forty male Wistar rats were divided into 5 groups; 8 weeks (C8) and 16 weeks control groups (C16), groups that received high carbohydrate high fructose (HCHF) diet for 8 weeks (MS8) and 16 weeks (MS16), and a group that received HCHF for 16 weeks with KH supplemented for the last 35 days (KH).

RESULTS:

Serum fasting blood glucose decreased in the KH group compared to MS16 group. HDL levels were significantly decreased in MetS groups compared to control groups. Open field experiments showed KH group exhibits less anxious behavior compared to the MetS group. Probe trial of Morris water maze demonstrated significant memory retention of KH group compared to MS16 group. Nissl staining showed significant decrease in pyramidal hippocampal cell in the MS16 compared to KH group.

CONCLUSION:

KH has the ability to normalise blood glucose and reduce serum triglyceride and LDL levels in MetS rats, while behavior studies complement its effect on anxiety and memory. This shows a promising role of KH in attenuating neurodegenerative diseases through the antioxidant activity of its polyphenolic content.

Friday, January 17, 2020

Manuka Honey May Help Treat Colorectal Cancer

The Influence of In Vitro Gastrointestinal Digestion on the Anticancer Activity of Manuka Honey

Antioxidants (Basel). 2020 Jan 10;9(1)

Manuka honey (MH) is a natural food with many beneficial properties to human health, thanks to its high variety of bioactive compounds; however, little is known about its bioaccessibility.

The aim of this study was to evaluate and compare the polyphenol compounds, the antioxidant capacity and the anticancer activity of MH subjected to an in vitro gastrointestinal digestion in human HCT-116 colon cancer cells.

Raw MH and digested MH (DMH) were assessed for total polyphenols and flavonoids by spectrophotometric and HPLC-ESI-MS/MS analysis, and total antioxidant capacity (TAC) using different methods. Cell viability, intracellular ROS production, apoptosis, cell cycle and colony formation capacity were tested after treatment with MH or DMH.

Results showed that total polyphenols, total flavonoids and TAC were significantly (p < 0.05) reduced after in vitro digestion. In addition, MH and DMH at 8, 16 and 24 mg/mL had similar effects in inducing intracellular ROS production and in inhibiting the colon formation ability; MH induced a more marked apoptosis compared to DMH, while cell cycle was blocked in S phase by MH and in Sub G1 phase by DMH.

Our results increase knowledge of the effect of gastrointestinal digestion on the biological effect of honey against colorectal cancer.

Thursday, January 09, 2020

Honey Protects Against Toxic Agents


Antidotal or protective effects of honey and one of its major polyphenols, chrysin, against natural and chemical toxicities

Acta Biomed. 2019 Dec 23;90(4):533-550

OBJECTIVE:

Honey and its polyphenolic compounds are of main natural antioxidants that have been used in traditional medicine. The aim of this review was to identify the protective effects of honey and chrysin (a polyphenol available in honey) against the chemical and natural toxic agents.

METHOD:

The scientific databases such as MEDLINE, PubMed, Scopus, Web of Science and Google Scholar were searched to identify studies on the antidotal effects of honey and chrysin against toxic agents.

RESULTS:

This study found that honey had protective activity against toxic agents-induced organ damages by modulating oxidative stress, inflammation, and apoptosis pathways. However, clinical trial studies are needed to confirm the efficacy of honey and chrysin as antidote agents in human intoxication.

CONCLUSION:

Honey and chrysin may be effective against toxic agents. (www.actabiomedica.it).

Thursday, January 02, 2020

Bee Pollen Shows Gut-Protecting Potential


Lipidomics Provides Novel Insights into Understanding the Bee Pollen Lipids Transepithelial Transport and Metabolism in Human Intestinal Cells

J Agric Food Chem. 2019 Dec 26

Bee pollen (BP) shows profound gut-protecting potentials. BP lipids (BPLs) mainly composed by phospholipids and polyunsaturated fatty acids might be one of the important contributors, while how BPL exerts gut-protecting effects and is transported through intestinal cell monolayers need to be investigated.

Here, we exploited a strategy that combines an UPLC-Q-exactive orbitrap/MS-based lipidomics approach with a human intestinal cell (Caco-2) monolayer transport model, to determine the transepithelial transportation of BPL from Camellia sinensis L. (BPL-Cs), in pathological conditions.

The results showed that BPL-Cs protected Caco-2 cells against dextran sulfate sodium (DSS)-induced intestinal barrier dysfunction by improving cell viability, maintaining membrane integrity, increasing tight junctions (ZO-1 and Claudin-1), and eliciting the expressions of antioxidative-related genes (NQO1, Nrf2, Txnrd1, and GSTA1). Lipidomics analysis revealed that DSS suppressed the transport and uptake of most of BPL-Cs including glycerophospholipids, sphingomyelins, and glycosylsphingolipids. Pretreatment with BPL-Cs significantly regulated glycerophospholipid and sphingolipid metabolisms, potentially involved in building permeability barriers and alleviating intestinal oxidative stress.

Finally, eight classes of lipids were identified as the potential biomarkers for evaluating DSS-induced Caco-2 cell dysfunctions and BPL-intervened modulation.

These findings shed light on the development of BPL as gastrointestinal protective food supplements in the future.

Friday, December 27, 2019

Royal Jelly Helps in Cognitive Support, Healing Wounds, Fertility Support, Antioxidant and Anti-Inflammatory Effects, Kidney and Liver Disease Support, Healthy Skin, Energy and Vitality, Digestive Support, Bone Support, Diabetic Support and Protection Against Neurodegenerative Diseases


Royal Jelly Health Benefits: Improves Collagen Levels And Mor

Dec 27, 2019

If you have no idea what royal jelly is, then it might sound like something either prestigious or expensive, sitting atop shelves out of reach of children. After all, it does say ‘royal’ in the name. But if you’re already familiar with what it does, then that opinion might not change at all since unsurprisingly so, royal jelly does deserve its name.

Why? Simple, because it’s been reported to have anti-diabetic, antioxidant, antibacterial and wound healing properties. And much like honey, it can be eaten too, with the benefit including asthma natural remedy, age-defying treatment, healthy bone development and to boost our immune system, and that’s not even all of it.

Here’s what you need to know about this amazing natural substance.

Royal Jelly

Similar to honey, royal jelly (RJ) is also produced by bees, although this nutritious substance is only produced by young nurse ones from the hive. As a substance, RJ contains a large amount of amino acids, which we can use for both reproduction and healthy cell growth. Bees usually use it for the nutrition of adult queen bees and her larvae. It's the sole food that queen and nurse bees eat all their lives, as well as what larvae eat for three days after hatching. In total, it’s the main food of bees, while honey is used to provide them energy...

Saturday, December 21, 2019

Honey Boosts Effectiveness of Traditional Medicine


Natural deep eutectic characteristics of honey improve the bioactivity and safety of traditional medicines

J Ethnopharmacol. 2019 Dec 11:112460

ETHNOPHARMACOLOGICAL RELEVANCE:

Honey, an important additive with natural deep eutectic solvent (NADES) characteristics, has been used in traditional medicine for thousands of years.

AIM OF THE STUDY:

We investigated the quality-improving effects of honey on Astragali Radix (Mikvetch Root) (RA) as an example.

MATERIALS AND METHODS:

Decoctions of raw RA, fried RA, honey-fried RA, and a man-made- honey-fried RA were prepared and compared in cell-based bioactivity tests, chemical composition tests, as well as a bioavailability test with calycosin-7-O-β-D-glucoside.

RESULTS:

The addition of honey increased the concentrations of active compounds and their oral bioavailability, provided protection against acetylation, and consequently increased their bioactivity. These changes were also observed when a pure NADES-mimicking honey was used.

CONCLUSION:

Our findings provide a potential explanation as to why honey has long been used as traditional medicine additives and rationalize the application of honey and honey-like substance in producing pharmaceuticals.

Wednesday, December 18, 2019

Propolis-Enriched Stingless Bee Honey Successfully Treats Diabetic Foot Ulcer with Exposed Bone

Successful treatment of a diabetic foot ulcer with exposed bone using Trigona honey: a case study

J Wound Care. 2019 Dec 1;28(Sup12):S4-S8

Many studies have shown that honey might improve wound healing. However, its efficacy for large wounds which may be followed by a systemic effect remains unclear. The effectiveness of honey-based dressings in treating large diabetic foot ulcers (DFU) is still unknown.

This study presents the case of a 38-year-old female patient presenting with an extensive infected DFU with exposed bone. The DFU was treated with propolis-enriched Trigona honey, used as a single treatment, in a home visit setting. After two months' follow-up, the wound exhibited complete re-epithelialisation despite the patient's initial poor condition.

Tuesday, December 10, 2019

Manuka Honey Used to Fight Infections in Surgical Dressings


Potential of Manuka Honey as a Natural Polyelectrolyte to Develop Biomimetic Nanostructured Meshes With Antimicrobial Properties

Front. Bioeng. Biotechnol., 04 December 2019

The use of antibiotics has been the cornerstone to prevent bacterial infections; however, the emergency of antibiotic-resistant bacteria is still an open challenge.

This work aimed to develop a delivery system for treating soft tissue infections for: (1) reducing the released antimicrobial amount, preventing drug-related systemic side effects; (2) rediscovering the beneficial effects of naturally derived agents; and (3) preserving the substrate functional properties. For the first time, Manuka honey (MH) was proposed as polyelectrolyte within the layer-by-layer assembly. Biomimetic electrospun poly(ε-caprolactone) meshes were treated via layer-by-layer assembly to obtain a multilayered nanocoating, consisting of MH as polyanion and poly-(allylamine-hydrochloride) as polycation. Physicochemical characterization demonstrated the successful nanocoating formation.

Different cell lines (human immortalized and primary skin fibroblasts, and primary endothelial cells) confirmed positively the membranes cytocompatibility, while bacterial tests using Gram-negative and Gram-positive bacteria demonstrated that the antimicrobial MH activity was dependent on the concentration used and strains tested.