Monday, November 12, 2018

Propolis Beats Anti-Viral Drug Aciclovir in Treating Cold Sores (Herpes Simplex Labialis)


Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage) : Randomized, controlled double-blind study.

Wien Med Wochenschr. 2018 Nov 7

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A lip cream with special propolis extract GH 2002 at a concentration of 0.5% (199 patients) was tested against aciclovir 5% (198 patients) in the treatment of episodes of herpes labialis under double-blind conditions. Upon inclusion, all patients were in the vesicular phase.

Application was five times daily of approximately 0.2 g of cream to the entire upper and lower lip. The primary parameter was the difference in time between groups to complete encrustation or epithelization of the lesions. Secondary endpoints were the course of typical herpes symptoms (pain, burning and itching, tension and swelling), the global assessment of efficacy and the safety of application. The predefined clinical situation was reached after a (median) 3 days with propolis and 4 days with aciclovir (p < 0.0001).

Significant differences in favor of propolis were also found for all secondary parameters. No allergic reactions, local irritations or other adverse events occurred.

Sunday, November 11, 2018

Honey Helps in the Treatment of Scalp Psoriasis

Clinical and Videodermoscopic Evaluation of the Efficacy, Safety, and Tolerability of a Shampoo Containing Ichthyol, Zanthalene, Mandelic Acid, and Honey in the Treatment of Scalp Psoriasis

Skin Appendage Disord. 2018 Oct;4(4):296-300

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Purpose of the Study:

The aim of the present prospective multicenter open study was to clinically and instrumentally evaluate the efficacy, safety, and tolerability of a shampoo, Mellis Cap® shampoo, containing ichthyol, zanthalene, mandelic acid, and honeydew honey in the treatment of mild to moderate scalp psoriasis.

Procedures:

Thirty subjects with mild to moderate psoriasis applied the shampoo three times a week for 12 weeks. The outcome was evaluated at 30 days (T1), 60 days (T2), and 90 days (T3) of treatment, comparing it to baseline (T0) by means of clinical and patients' evaluation, digital photographs, and videodermoscopy.

Results:

Clinical and patients' evaluation showed improvement of scalp psoriasis and itching. This was confirmed by videodermoscopy analysis with a significant reduction of scalp psoriasis severity at T2 and T3 compared to baseline. No side effects were observed or reported.


Conclusions:
Study treatment was well tolerated and showed significant clinical and instrumental improvement of scalp psoriasis. Mellis Cap® shampoo is a good alternative to other medicated shampoos in the treatment of mild to moderate scalp psoriasis.

Saturday, November 10, 2018

Finnish Beekeepers Encouraged to Harvest Pollen and Bee Larvae as Foodstuffs


Grubs, pollen to create new buzz in beekeeping business

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UUTISET

On the heels of crunchy insect bread made from crickets, beekeepers in Finland are now looking to sweeten their margins with grubs and pollen.

Finnish apiarists are inceasingly interested in producing insect-related foodstuffs in addition to honey, according to the Finnish Beekeepers' Association.

"It's a way for beekeepers to get some extra income on top of their honey production," project chief Anneli Salonen from the association told Yle.

Bee-entrepreneurs looking to sweeten their business, are exploring adding protein-rich grubs of drone bees and pollen to their product ranges. Pollen and grub collection does not disturb the life of a beehive, as the worker bees that run much of the hive are undisturbed in the process.

But everyone isn't jumping at a chance to introduce their taste buds to bee larvae...

Introducing 'bee glue'

One of the lesser-known by-products of beekeeping is propolis, a resinous wax known as 'bee glue' that is produced when bees collect resins from trees and other plants.

Propolis has numerous uses both inside a hive as well as on a plate.

"A propolis shell protects the hive and its entry points," Salonen said. "It is also a disinfectant and antibiotic, so it defends the hive against bacteria and microbes. Once stung, bees also coat intruders such as mice with propolis, embalming them in the hive."

Consumers can meanwhile look forward to propolis-based nutritional supplements touted for their anti-inflammatory properties, according to Salonen.

Thursday, November 08, 2018

Propolis May Help Treat Necrosis of the Liver


Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis by modulating inflammation-related factors in rats

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J Toxicol Pathol. 2018 Oct;31(4):275-282

Propolis is a resin-like material produced by honey bees from bud exudates and sap of plants and their own secretions. An ethanol extract of Brazilian green propolis (EEBGP) contains prenylated phenylpropanoids and flavonoids and has antioxidative and anti-inflammatory effects.

Acetaminophen (N-acetyl-p-aminophenol; APAP) is a typical hepatotoxic drug, and APAP-treated rats are widely used as a model of drug-induced liver injury. Oxidative stress and inflammatory reactions cause APAP-induced hepatocellular necrosis and are also related to expansion of the lesion. In the present study, we investigated the preventive effects of EEBGP on APAP-induced hepatocellular necrosis in rats and the protective mechanism including the expression of antioxidative enzyme genes and inflammation-related genes.

A histological analysis revealed that administration 0.3% EEBGP in the diet for seven days reduced centrilobular hepatocellular necrosis with inflammatory cell infiltration induced by oral administration of APAP (800 mg/kg) and significantly reduced the area of necrosis. EEBGP administration did not significantly change the mRNA expression levels of antioxidant enzyme genes in the liver of APAP-treated rats but decreased the mRNA expression of cytokines including Il10 and Il1b, with a significant difference in Il10 expression.

In addition, the decrease in the mRNA levels of the Il1b and Il10 genes significantly correlated with the decrease in the percentage of hepatocellular necrosis.

These findings suggest that EEBGP could suppress APAP-induced hepatocellular necrosis by modulating cytokine expression.

Wednesday, November 07, 2018

Propolis as a Probiotic May Boost Gut Microbiota


Resveratrol and propolis: Two promising targets to boost gut microbiota

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05-Nov-2018 By Tingmin Koe

Recent studies have revealed how polyphenols can alter gut microbes, suggesting they are worthy of further examination alongside probiotics to boost health outcomes.

Tuesday, November 06, 2018

Propolis Nanofibers May Help Wound Healing


Electrospinning of zein/propolis nanofibers; antimicrobial properties and morphology investigation

Journal of Materials Science: Materials in Medicine
November 2018, 29:165

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In this work, for the first time, zein nanofiber mats loaded with ethanol extracts propolis (EEP) were successfully produced.

Raw propolis was extracted by ethanol 70% and total flavonoid content was estimated by aluminum chloride colorimetric method. The anti-microbial activity of the EEP was investigated and compared with amoxicillin via zone of inhibition test against various microorganisms included gram-positive: Staphylococcus aureus, Staphylococcus epidermidis, gram-negative: Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa and fungus: Candida albicans.

The EEP showed activity only against gram-positive types and fungus, whereas no activity was observed against gram-negative types. Electrospun zein nanofiber was obtained from 70% ethanolic solutions included different content of zein, 15–40 wt.%. The SEM images revealed a smooth ribbon-like morphology for zein nanofibers without any beads in zein content more than 25 wt.%. As well, the SEM images of electrospun zein nanofibers containing different content of propolis (0–40 wt.% based on the zein content) disclosed the increase in the average size of fibers with propolis content from 264 to 419 nm. This increasing was more probably due to the reduction in ionic conductivity of zein solutions with propolis content.

The proteinic nature of zein along with the antimicrobial activity and the herbal nature of the propolis make the obtained mats promising candidate for more evaluation in wound healing study.

Monday, November 05, 2018

VIDEO: Bee Venom Used to Treat Pain, Lyme Disease, Multiple Sclerosis (MS), Arthritis


Honey Bee’s venom used to treat pain

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PROVIDENCE, R.I. (WJAR) — Local honey has long been touted as a way to treat allergies.

But did you know the honey bee's venom can take the sting out of pain? Or so, some say.

It’s part of apitherapy.

"It's an ancient art in medicine and incorporates all the products of the bee hive as the medicine chest," said Frederique Keller, a licensed acupuncturist in New York and the President of the American Apitherapy Association.

"The venom has 60 identifiable components as well as some unidentifiable ones,” said Keller. “The two biggest ones are appemine and melittin and one is a peptide 401 that's what it's called. It's 100 times more potent than cortisone."...

Sunday, November 04, 2018

Propolis Boosts Wound Healing


Transdermal Hydrogel Composed of Polyacrylic Acid Containing Propolis for Wound Healing in a Rat Model

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Macromolecular Research

The aim of this study was to investigate the effect of the Carbopol® hydrogel containing propolis (CHP) on wound healing in a rat model. CHP extracts inhibited nitric oxide production induced by lipopolysaccharide in RAW264.7 cells with a concentration-dependent manner.

Wounds were prepared through excision to remove full-thickness skin of rats k]and then were covered with CHP. The covered wounds showed significantly rapid contraction and closure. Histological tissue examination indicated that CHP induced advanced granulation tissue formation and re-epithelialization in the wound.

These results indicate that CHP may be helpful for the promotion of wound healing.

Saturday, November 03, 2018

Honey May Help Treat Wounds Using Maggot Debridement Therapy

In vitro evaluation of the association of medicinal larvae (Insecta, Diptera, Calliphoridae) and topical agents conventionally used for the treatment of wounds

Acta Trop. 2018 Oct 29. pii: S0001-706X(18)30549-7

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Wound healing is a complex process involving multiple biochemical and cellular events and represents a neglected public health issue. As a consequence, millions of people worldwide suffer from chronic wounds. The search for new treatment alternatives is therefore an important issue.

In the context of wound healing, Maggot Debridement Therapy (MDT) is an inexpensive treatment with few contraindications and very promising results. This study aimed to evaluate the in vitro feasibility and implications of larvae (= MDT) use when combined with topical agents as a strategy to identify additive or synergistic combinations. The weight and survival rate of Cochliomyia macellaria (Fabricius) (Insecta, Diptera, Calliphoridae) larvae reared in an in vitro wound with either honey, hydrogel, 10% papain gel, essential fatty acids (EFA), collagenase, or silver sulfadiazine were evaluated after 24, 48 and 72 h. Hydrogel (for weight: 24 and 72 h; for survival: 24 h) and 10% papain gel (for weight: 48 h; for survival: 48 and 72 h) demonstrated the least interference in larval weight gain and survival rate, when compared to the control group.

The results obtained in this study showed that the combined use of larvae and hydrogel or 10% papain gel may be promising to maximize the tissue repair. Honey, EFA and collagenase could be used to prepare the bed of the dry wounds to receive the MDT.

Friday, November 02, 2018

Brazilian Red Propolis Shows Anti-Bacterial, Anti-Fungal, Antioxidant, and Anti-Cancer Activity


Phytochemical screening and in vitro antibacterial, antifungal, antioxidant and antitumor activities of the red propolis Alagoas

Braz J Biol. 2018 Oct 29. pii: S1519-69842018005029101

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The study aimed to evaluate the antimicrobial activity, antioxidant, toxicity and phytochemical screening of the Red Propolis Alagoas.

Antimicrobial activity was evaluated by disk diffusion method. Determination of antioxidant activity was performed using the DPPH assay (1.1-diphenyl-2-picrylhydrazyl), FTC (ferric thiocyanate) and determination of phenolic compounds by Follin method. Toxicity was performed by the method of Artemia salina and cytotoxicity by MTT method. The phytochemical screening for the detection of allelochemicals was performed.

The ethanol extract of propolis of Alagoas showed significant results for antimicrobial activity, and inhibitory activity for Staphylococcus aureus and Candida krusei. The antioxidant activity of the FTC method was 80% to 108.3% hydrogen peroxide kidnapping, the DPPH method showed an EC50 3.97 mg/mL, the content of total phenolic compounds was determined by calibration curve gallic acid, resulting from 0.0005 mg/100 g of gallic acid equivalent. The extract was non-toxic by A. salina method.

The propolis extract showed high activity with a higher percentage than 75% inhibition of tumor cells OVCAR-8, SF-295 and HCT116. Chemical constituents were observed as flavonones, xanthones, flavonols, and Chalcones Auronas, Catechins and leucoanthocyanidins.

It is concluded that the extract can be tested is considered a potential source of bioactive metabolites.

Thursday, November 01, 2018

Taiwanese Propolis May Help Treat Gout (Gouty Inflammation)


Mechanistic insight into the attenuation of gouty inflammation by Taiwanese green propolis via inhibition of the NLRP3 inflammasome

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J Cell Physiol. 2018 Oct 28

Dysregulation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is involved in many chronic inflammatory diseases, including gouty arthritis. Activation of the NLRP3 inflammasome requires priming and activation signals: the priming signal controls the expression of NLRP3 and interleukin (IL)-1β precursor (proIL-1β), while the activation signal leads to the assembly of the NLRP3 inflammasome and to caspase-1 activation.

Here, we reported the effects of the alcoholic extract of Taiwanese green propolis (TGP) on the NLRP3 inflammasome in vitro and in vivo. TGP inhibited proIL-1β expression by reducing nuclear factor kappa B activation and reactive oxygen species (ROS) production in lipopolysaccharide-activated macrophages. Additionally, TGP also suppressed the activation signal by reducing mitochondrial damage, ROS production, lysosomal rupture, c-Jun N-terminal kinases 1/2 phosphorylation and apoptosis-associated speck-like protein oligomerization.

Furthermore, we found that TGP inhibited the NLRP3 inflammasome partially via autophagy induction. In the in vivo mouse model of uric acid crystal-induced peritonitis, TGP attenuated the peritoneal recruitment of neutrophils, and the levels of IL-1β, active caspase-1, IL-6 and monocyte chemoattractant protein-1 in lavage fluids. As a proof of principle, in this study, we purified a known compound, propolin G, from TGP and identified this compound as a potential inhibitor of the NLRP3 inflammasome.

Our results indicated that TGP might be useful for ameliorating gouty inflammation via inhibition of the NLRP3 inflammasome.

Wednesday, October 31, 2018

Royal Jelly Has Anti-Cancer Effects


Anti-Cancer and Protective Effects of Royal Jelly for Therapy-Induced Toxicities in Malignancies

Int J Mol Sci. 2018 Oct 21;19(10)

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Royal jelly (RJ) is a glandular secretion produced by worker honeybees and is a special food for the queen honeybee. It results in a significant prolongation of the lifespan of the queen honeybee compared with the worker honeybees through anti-inflammatory, anti-oxidant and anti-microbial activities.

Consequently, RJ is used as cosmetic and dietary supplement throughout the world. In addition, in vitro studies and animal experiments have demonstrated that RJ inhibits cell proliferation and stimulates apoptosis in various types of malignant cells and affects the production of various chemokines, anti-oxidants and growth factors and the expression of cancer-related molecules in patients with malignancies, especially in patients treated with anti-cancer agents.

Therefore, RJ is thought to exert anti-cancer effects on tumor growth and exhibit protective functions against drug-induced toxicities. RJ has also been demonstrated to be useful for suppression of adverse events, the maintenance of the quality of life during treatment and the improvement of prognosis in animal models and patients with malignancies.

To understand the mechanisms of the beneficial effects of RJ, knowledge of the changes induced at the molecular level by RJ with respect to cell survival, inflammation, oxidative stress and other cancer-related factors is essential. In addition, the effects of combination therapies of RJ and other anti-cancer agents or natural compounds are important to determine the future direction of RJ-based treatment strategies.

Therefore, in this review, we have covered the following five issues: (1) the anti-cancer effects of RJ and its main component, 10-hydroxy-2-decenoic acid; (2) the protective effects of RJ against anti-cancer agent-induced toxicities; (3) the molecular mechanisms of such beneficial effects of RJ; (4) the safety and toxicity of RJ; and (5) the future directions of RJ-based treatment strategies, with a discussion on the limitations of the study of the biological activities of RJ.

Tuesday, October 30, 2018

Honey Does Not Have Impact on Glucose and Insulin Concentrations in Obese Girls Compared to Sugar

Effect of Honey on Glucose and Insulin Concentrations in Obese Girls

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Eur J Clin Invest. 2018 Oct 28:e13042

BACKGROUND:

Childhood obesity represents a major health problem of our century. The benefits of natural products, such as honey, in the management of obesity have gained renewed interest. In this study, we investigated the effect of honey on glucose and insulin concentrations in obese prepubertal girls.

MATERIALS AND METHODS:

Thirty healthy obese girls aged 10.55 (±SEM:0.34) years with a mean body mass index (BMI) above the 97th centile for age (28.58±1.40 kg/m2 , BMI z-score 2.96) underwent a standard oral glucose tolerance test (OGTT) followed by an oral honey tolerance test (OHTT) two weeks later. Both solutions contained 75g of glucose. Subsequently, subjects were randomized to receive either 15g of honey or 15g of marmalade daily, while both groups complied with dietetic instructions. Six months later all subjects were re-valuated with an OGTT and an OHTT.

RESULTS:

At the end of the study, all subjects demonstrated a significant reduction in BMI (27.57±1.40, z-score:2.54 vs. 28.58±1.40 kg/m2 , z-score:2.96, P < 0.001), however there were no significant differences in BMI and all parameters tested between the group that received honey and the control group. The areas under the concentration-time curve for glucose and insulin for the entire population were significantly lower following ingestion of honey than glucose solution (P < 0.001) both at the beginning and at the end of study.

CONCLUSIONS:

These findings indicate that honey does not have an effect on stimulated plasma glucose and serum insulin concentrations compared with the standard glucose solution in obese prepubertal girls.

Monday, October 29, 2018

6 Ways to Integrate Manuka Honey Into Your Wellness Routine

Care2

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Historical records of wellness uses for honey date back to the earliest civilizations, showing that honey has been used both as a vehicle for other ingredients and for its therapeutic benefits for centuries. What they prized then is what we prize now: honey’s incredible antimicrobial properties.

Honey’s antimicrobial nature is even more potent in the wellness community’s golden child, manuka honey. This particular honey, which is native to New Zealand, features higher amounts of the active antimicrobial compound, methylglyoxal (MG), which protects against bacteria and boosts production of cells that can repair tissue damaged by infection, as well as the omega-3 fatty acid, DHA. Sweet, right?

All this means that manuka honey can be used as a salve to treat wounds, cuts, acute burns and even bed sores. Put it on a wound and the liquid gets drawn up into the honey, sucking out impurities and protecting the body against infection. Medical grade manuka can also restore the natural pH levels of the skin and remove dead tissues. Hello, skincare!

1. Wash your face.
To use, simply wash your face the same way you would with a normal cleanser. Just wet your face, slather on a dollop of honey, gently massage and rinse throughly with lukewarm water. This is a great method for sensitive skin!

2. Soothe a cough.
Swallow two spoonfuls of honey mixed with milk to soothe a cough or sore throat. It will take out bacteria on the way down, so you get healthy more quickly! Plus, it tastes delicious.

3. Make a face mask.
Mix a heaping tablespoon of manuka honey with some lemon juice and cinnamon. This mixture helps clear pores and will make your skin brighter and glowy...

Sunday, October 28, 2018

Propolis Component May Help Treat Parkinson's Disease (PD)


Caffeic acid improves locomotor activity and lessens inflammatory burden in a mouse model of rotenone-induced nigral neurodegeneration: Relevance to Parkinson's disease therapy

Pharmacol Rep. 2018 Aug 11;71(1):32-41

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BACKGROUND:

Caffeic acid phenethyl ester is found in honey bee propolis. It has immunomodulatory, anti-inflammatory and anti-cancer properties. Rotenone is a pesticide commonly used for inducing experimental Parkinson's disease (PD) due to complex I inhibition and microglia activating properties. The current study examined neuroprotective effect of caffeic acid against rotenone-induced neurodegeneration in groups of seven mice.

METHODS:

Mice received protective doses of caffeic acid (2.5, 5 or 10 mg/kg) daily and nine injections of rotenone (1 mg kg, subcutaneously) - every 48 h. Behavioral evaluation of motor function was done by a battery of tests including open-field test, cylinder test, pole test and rotarod test; all these tests showed motor impairment.

RESULTS:

Assay of striatal dopamine highlighted a significant decrease and increases in inflammatory markers. In addition, histopathological assessment of substantia nigra neurons demonstrated low immunostaining for tyrosine hydroxylase (TH) in rotenone treated mice. PCR analysis highlighted upregulation for genes encoding CD11b (a microglia surface antigen), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and nuclear factor-κB (NFκB). Treatment with caffeic acid (5 or 10 mg/kg) amended most of rotenone-induced motor deficits, lessened microglia expression and inflammatory mediators and improved the nigral TH immunostaining.

CONCLUSION:

These results confirmed the anti-inflammatory activity of caffeic acid and highlighted its neuroprotective activity against rotenone-induced neurodegeneration in mice.