Monday, January 26, 2015

Manuka Honey Used to Treat Athlete’s Foot

What Are The Benefits of Manuka Honey?
The Huffington Post Canada, 1/23/2015

Nutritionists have been telling us to avoid processed foods and sugar, so it's no surprise that ingredients from different parts of the world are taking up space in our pantry to replace them.

Manuka honey, which comes from New Zealand, is one of those superfoods that claims to help a host of ailments all in one teaspoonful. It's collected from honeybees that forage at native manuka (or tea tree) trees in New Zealand, according to the NHS. Tea tree is well-known for its antibacterial, antifungal and antiviral activity.

The active ingredient in the honey, methylglyoxal (MG) has been given a rating known as UMF (Unique Manuka Factor), which helps to differentiate the honey between the many fake products sold on the market. A rating of 10 or higher is considered therapeutic, explains…

If you're suffering from a fungal infection like athlete's foot, nail fungus or ringworm, manuka honey could help clear it up. Put the honey on the affected area, instructs, and cover with cotton socks.

Sunday, January 25, 2015

New Manuka Honey Wound Dressings

David Navazio Announces New Gentell Wound Care Products Made With Honey

Gentell Honey Gauze “Manuka” Dressing and Gentell Honey Alginate Dressing, both made with medical grade honey, are designed to treat wet or dry wounds.

Bristol, PA (PRWEB) January 24, 2015

David Navazio, Executive Vice President and Founder of Gentell, Inc. (, a leading manufacturer of wound and skin care products, recently announced the availability of two new wound care products designed to be highly effective in treating both wet and dry wounds.

Gentell Honey Gauze Dressing, impregnated with 100% Leptospermum (Manuka) Medical Grade Honey, helps promote moist healing in challenging wounds and burns exhibiting low volumes of exudate (fluid). Gentell Honey Alginate Dressing, also infused with 100% Leptospermum Medical Grade Honey, supports moist healing in challenging wounds and burns exhibiting higher volumes of exudate. Gentell offers the Honey Gauze Dressing in 4” x 4”, and the Honey Alginate Dressings in 2”x 2” and 4.5” x 4.5” sizes.

“The use of medical grade honey for the treatment of aggressive or chronic wounds is currently resurging in popularity,” David Navazio observed. “A growing number of customers have inquired specifically about wound products designed with medical grade honey. We introduced Gentell gauze and calcium alginate dressings to meet the growing demand.”…

Saturday, January 24, 2015

Honey is a Natural Cure

5 First Aid Options That Are In Your Kitchen Right Now

Health AIM, 1/23/2015

Providing an appropriate first aid is crucial in dealing with a sudden onset of injury or illness. It is always advisable to keep a professional first aid kit to combat major emergencies. But what would you do while dealing with minor ailments that really do not require a visit to the doctor? Here is a list of things that can come in handy while dealing with minor health issues. Interesting thing is that you may already have them in your kitchen.

Honey: Honey is a natural cure, if you are suffering with a terrible hangover. The antioxidants present in honey detoxify the body and provide a soothing effect. The potassium content helps with salt imbalance as well. Manuka honey, extracted from manuka tree common in Australia and New Zealand, can be extremely helpful when it comes to minor wounds and skin infections. The antibacterial properties are a result of a compound called Unique Manuka Factor (UMF)…

Friday, January 23, 2015

Brazilian Red Propolis Prevents Kidney Damage

Brazilian Red Propolis Attenuates Hypertension and Renal Damage in 5/6 Renal Ablation Model
PLoS One. 2015 Jan 21;10(1):e0116535

The pathogenic role of inflammation and oxidative stress in chronic kidney disease (CKD) is well known. Anti-inflammatories and antioxidant drugs has demonstrated significant renoprotection in experimental nephropathies. Moreover, the inclusion of natural antioxidants derived from food and herbal extracts (such as polyphenols, curcumin and lycopene) as an adjuvant therapy for slowing CKD progression has been largely tested. Brazilian propolis is a honeybee product, whose anti-inflammatory, antimicrobial and antioxidant effects have been widely shown in models of sepsis, cancer, skin irritation and liver fibrosis. Furthermore, previous studies demonstrated that this compound promotes vasodilation and reduces hypertension. However, potential renoprotective effects of propolis in CKD have never been investigated.

The aim of this study was to evaluate the effects of a subtype of Brazilian propolis, the Red Propolis (RP), in the 5/6 renal ablation model (Nx). Adult male Wistar rats underwent Nx and were divided into untreated (Nx) and RP-treated (Nx+RP) groups, after 30 days of surgery; when rats already exhibited marked hypertension and proteinuria. Animals were observed for 90 days from the surgery day, when Nx+RP group showed significant reduction of hypertension, proteinuria, serum creatinine retention, glomerulosclerosis, renal macrophage infiltration and oxidative stress, compared to age-matched untreated Nx rats, which worsened progressively over time.

In conclusion, RP treatment attenuated hypertension and structural renal damage in Nx model. Reduction of renal inflammation and oxidative stress could be a plausible mechanism to explain this renoprotection.

Thursday, January 22, 2015

Allergy After Ingestion of Bee-Gathered Pollen: Influence of Botanical Origins

Ann Allergy Asthma Immunol, Published Online: January 16, 2015
Bee-gathered pollen is increasingly consumed around the world because of its purported nutritive and therapeutic values. Although rare, ingested pollens can induce severe adverse reactions, particularly in allergic individuals. These risks are exacerbated by the fact that products sold as “bee pollen” are made up of variable content, making them difficult to characterize and standardize. Until recently, several case reports reviewed by Jagdis and Sussman have described anaphylactic reactions after ingesting bee pollen supplements.

Wednesday, January 21, 2015

New Zealand Manuka Trial Scheme Pleasing

Sun Live, 1/21/2015

A trial scheme along a small plantation for manuka honey and oil on the Rangitaiki riverbank is providing pleasing results.

Bay of Plenty Regional Council is working with the Rangitaiki River Forum, Maori Lands Trusts, local landowners, Trust Power and Manuka Bioactives Limited to trial the scheme.

The international market for manuka products is strong and may provide an opportunity for landholders to plant a native species in marginal land areas to generate a small income...

Tuesday, January 20, 2015

Bee Venom May Help Treat Acne

Complementary therapies for acne vulgaris
Cochrane Database Syst Rev. 2015 Jan 19;1:CD009436


Acne is a chronic skin disease characterised by inflamed spots and blackheads on the face, neck, back, and chest. Cysts and scarring can also occur, especially in more severe disease. People with acne often turn to complementary and alternative medicine (CAM), such as herbal medicine, acupuncture, and dietary modifications, because of their concerns about the adverse effects of conventional medicines. However, evidence for CAM therapies has not been systematically assessed.


To assess the effects and safety of any complementary therapies in people with acne vulgaris.


We searched the following databases from inception up to 22 January 2014: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL; 2014,Issue 1), MEDLINE (from 1946), Embase (from 1974), PsycINFO (from 1806), AMED (from 1985), CINAHL (from 1981), Scopus (from 1966), and a number of other databases listed in the Methods section of the review. The Cochrane CAM Field Specialised Register was searched up to May 2014. We also searched five trials registers and checked the reference lists of articles for further references to relevant trials.


We included parallel-group randomised controlled trials (or the first phase data of randomised cross-over trials) of any kind of CAM, compared with no treatment, placebo, or other active therapies, in people with a diagnosis of acne vulgaris.


Three authors collected data from each included trial and evaluated the methodological quality independently. They resolved disagreements by discussion and, as needed, arbitration by another author.


We included 35 studies, with a total of 3227 participants. We evaluated the majority as having unclear risk of selection, attrition, reporting, detection, and other biases. Because of the clinical heterogeneity between trials and the incomplete data reporting, we could only include four trials in two meta-analyses, with two trials in each meta-analysis. The categories of CAM included herbal medicine, acupuncture, cupping therapy, diet, purified bee venom (PBV), and tea tree oil. A pharmaceutical company funded one trial; the other trials did not report their funding sources.Our main primary outcome was 'Improvement of clinical signs assessed through skin lesion counts', which we have reported as 'Change in inflammatory and non-inflammatory lesion counts', 'Change of total skin lesion counts', 'Skin lesion scores', and 'Change of acne severity score'. For 'Change in inflammatory and non-inflammatory lesion counts', we combined 2 studies that compared a low- with a high-glycaemic-load diet (LGLD, HGLD) at 12 weeks and found no clear evidence of a difference between the groups in change in non-inflammatory lesion counts (mean difference (MD) -3.89, 95% confidence interval (CI) -10.07 to 2.29, P = 0.10, 75 participants, 2 trials, low quality of evidence). However, although data from 1 of these 2 trials showed benefit of LGLD for reducing inflammatory lesions (MD -7.60, 95% CI -13.52 to -1.68, 43 participants, 1 trial) and total skin lesion counts (MD -8.10, 95% CI -14.89 to -1.31, 43 participants, 1 trial) for people with acne vulgaris, data regarding inflammatory and total lesion counts from the other study were incomplete and unusable in synthesis.Data from a single trial showed potential benefit of tea tree oil compared with placebo in improving total skin lesion counts (MD -7.53, 95% CI -10.40 to -4.66, 60 participants, 1 trial, low quality of evidence) and acne severity scores (MD -5.75, 95% CI -9.51 to -1.99, 60 participants, 1 trial). Another trial showed pollen bee venom to be better than control in reducing numbers of skin lesions (MD -1.17, 95% CI -2.06 to -0.28, 12 participants, 1 trial).Results from the other 31 trials showed inconsistent effects in terms of whether acupuncture, herbal medicine, or wet-cupping therapy were superior to controls in increasing remission or reducing skin lesions.Twenty-six of the 35 included studies reported adverse effects; they did not report any severe adverse events, but specific included trials reported mild adverse effects from herbal medicines, wet-cupping therapy, and tea tree oil gel.Thirty trials measured two of our secondary outcomes, which we combined and expressed as 'Number of participants with remission'. We were able to combine 2 studies (low quality of evidence), which compared Ziyin Qinggan Xiaocuo Granule and the antibiotic, minocycline (100 mg daily) (worst case = risk ratio (RR) 0.49, 95% CI 0.09 to 2.53, 2 trials, 206 participants at 4 weeks; best case = RR 2.82, 95% CI 0.82 to 9.06, 2 trials, 206 participants at 4 weeks), but there was no clear evidence of a difference between the groups.None of the included studies assessed 'Psychosocial function'.Two studies assessed 'Quality of life', and significant differences in favour of the complementary therapy were found in both of them on 'feelings of self-worth' (MD 1.51, 95% CI 0.88 to 2.14, P < 0.00001, 1 trial, 70 participants; MD 1.26, 95% CI 0.20 to 2.32, 1 trial, 46 participants) and emotional functionality (MD 2.20, 95% CI 1.75 to 2.65, P < 0.00001, 1 trial, 70 participants; MD 0.93, 95% CI 0.17 to 1.69, 1 trial, 46 participants).Because of limitations and concerns about the quality of the included studies, we could not draw a robust conclusion for consistency, size, and direction of outcome effects in this review.


There is some low-quality evidence from single trials that LGLD, tea tree oil, and bee venom may reduce total skin lesions in acne vulgaris, but there is a lack of evidence from the current review to support the use of other CAMs, such as herbal medicine, acupuncture, or wet-cupping therapy, for the treatment of this condition. There is a potential for adverse effects from herbal medicines; however, future studies need to assess the safety of all of these CAM therapies. Methodological and reporting quality limitations in the included studies weakened any evidence. Future studies should be designed to ensure low risk of bias and meet current reporting standards for clinical trials.

Monday, January 19, 2015

Royal Jelly Increases Nuclear Maturation and GSH Synthesis

305 royal jelly treatment during oocyte maturation improves in vitro meiotic competence of goat oocytes by influencing intracellular glutathione synthesis and apoptosis gene expression
Reprod Fertil Dev. 2014 Dec;27(1):241. doi: 10.1071/RDv27n1Ab305.

Royal jelly (RJ) is a secretion product from the cephalic glands of nurse bees that has extraordinary properties and remarkable health effects. Over the years, antioxidative and antiapoptotic properties of RJ have been experimentally investigated. Here we hypothesised that supplementary RJ in in vitro maturation (IVM) medium would (i) improve cumulus expansion (ii) oocyte nuclear maturation, (iii) glutathione (GSH) content, and (iv) mitochondrial activity, and (v) also affect the mRNA abundance of the (Bax, Bcl-2, and p53) transcripts involved in oocyte apoptosis.

To test these hypotheses, goat ovaries were collected from a local abattoir and transported to the laboratory. Cumulus-oocyte complexes (COC) with multilayered compact cumulus investment and evenly granulated cytoplasm were selected and randomly allocated to the experiments. To evaluate the effects of RJ on meiotic competence after maturation in vitro, IVM medium was supplemented with concentration of 0.0 (RJ-0), 2.5 (RJ-2.5), 5.0 (RJ-5), and 10.0 (RJ-10) mgmL(-1) of RJ. After IVM, oocytes of each group were evaluated for cumulus expansion (visual assessment), stage of nuclear maturation (Hoechst staining), intracellular level of GSH (Cell Tracker blue staining), mitochondrial activity (MitoTracker Deep Red staining), and relative expression of Bax, Bcl-2, and p53 genes (qRT-PCR assay). Differences were analysed for significance by one-way ANOVA using SAS version 8.0 (SAS Institute Inc., Cary, NC, USA), considering P < 0.05 to be significant. Supplementation of the maturation media with RJ did not appear to affect cumulus expansion (P > 0.05).

Our results revealed that maturation rate was higher (88.0%) in the RJ-10 group when compared with the RJ-2.5 (71.5%) and control (RJ-0) groups (60.0%; P < 0.05), but similar with the RJ-5 group (81%; P > 0.05). A higher (P < 0.05) GSH content was detected when comparisons were made between each concentration of RJ-treated (i.e. RJ-2.5, RJ-5, and RJ-10) oocytes and the control (RJ-0) oocytes; however the differences were not significant when RJ groups were compared. No difference (P>0.05) was observed among RJ-treated and untreated oocytes regarding their mitochondrial activity after IVM. Based on these results, the concentration of 10mgmL(-1) (RJ-10) was selected for evaluation of Bax, Bcl-2, and p53 transcripts abundance.

Our results revealed that the expression of Bax mRNA was decreased (P < 0.05) in RJ-10 group when compared with control (RJ-0) group. Furthermore, there was an increased (P < 0.05) expression of Bcl-2 transcripts in RJ-10 group when compared to the control (RJ-0) group. The p53 transcript also tended to be higher in RJ-10 group than in the control (RJ-0) group, although this difference was not statistically significant (P > 0.05). In conclusion, results of this study showed that adding RJ to maturation medium at optimum concentration increased the nuclear maturation and GSH synthesis, but not activity of the mitochondria; this improvement was associated with expression of apoptosis-related genes in goat oocytes.

Sunday, January 18, 2015

Honey, Propolis Component Has Anti-Cancer Activity

Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
Toxicol Lett. 2015 Jan 14. pii: S0378-4274(15)00020-X

Chrysin, a naturally occurring flavone, abundantly found in numerous plant extracts including propolis and in honey is one of the most widely used herbal medicine in Asian countries. Nowadays, chrysin has become the foremost candidate exhibiting health benefits, owing to its multiple bioactivities such as antioxidant, anti-inflammatory, anti-allergic, anti-diabetic, anti-estrogenic, antibacterial and antitumor activities. Anticancer activity is most promising among the multiple pharmacological effects displayed by chrysin. In vitro and in vivo models have shown that chrysin inhibits cancer growth through induction of apoptosis, alteration of cell cycle and inhibition of angiogenesis, invasion and metastasis without causing any toxicity and undesirable side effects to normal cells. Chrysin displays these effects through selective modulation of multiple cell signaling pathways which are linked to inflammation, survival, growth, angiogenesis, invasion and metastasis of cancer cells. This broad spectrum of antitumor activity in conjunction with low toxicity underscores the translational value of chrysin in cancer therapy. The present review highlights the chemopreventive and therapeutic effects, molecular targets and antineoplastic mechanisms that contribute to the observed anticancer activity of chrysin.

Saturday, January 17, 2015

Honey Dressing vs. Povidone Iodine Dressing

November 2014
Dear editor, we would like to discuss on the publication on “Honey Dressing vs. Povidone Iodine Dressing [1].” Gulati et al. concluded that “Honey dressing is highly effective in achieving healing in chronic wounds as compared to Povidone iodine dressing [1].” In fact, the usefulness of honey in wound care is acceptable and honey is widely used. It is approved for the antibacterial activity and proposed to be a good therapeutic agent for infectious diseases [2]. However, the important consideration is the possible contamination of honey. Honey is reported for high contamination by Clostridium pathogen that can cause botulism [3]. To use honey in surgery, good preparation and sanitation control is needed.

Friday, January 16, 2015

Honey a Potential Antigiardial Agent

Antigiardial activity of glycoproteins and glycopeptides from Ziziphus honey
Nat Prod Res. 2015 Jan 14:1-3
Natural honey contains an array of glycoproteins, proteoglycans and glycopeptides. Size-exclusion chromatography fractionated Ziziphus honey proteins into five peaks with molecular masses in the range from 10 to >200 kDa. The fractionated proteins exhibited in vitro activities against Giardia lamblia with IC50 values ≤ 25 μg/mL. Results indicated that honey proteins were more active as antiprotozoal agents than metronidazole. This study indicated the potential of honey proteins and peptides as novel antigiardial agents.

Thursday, January 15, 2015

Bee Venom Accupunture Delay Development and Progression of Neurodegenerative Disorder

Bee Venom Acupuncture Alleviates Experimental Autoimmune Encephalomyelitis by Upregulating Regulatory T Cells and Suppressing Th1 and Th17 Responses

Mol Neurobiol. 2015 Jan 13

The protective and therapeutic mechanism of bee venom acupuncture (BVA) in neurodegenerative disorders is not clear. We investigated whether treatment with BVA (0.25 and 0.8 mg/kg) at the Zusanli (ST36) acupoints, located lateral from the anterior border of the tibia, has a beneficial effect in a myelin basic protein (MBP)68-82-induced acute experimental autoimmune encephalomyelitis (EAE) rat model. Pretreatment (every 3 days from 1 h before immunization) with BVA was more effective than posttreatment (daily after immunization) with BVA with respect to clinical signs (neurological impairment and loss of body weight) of acute EAE rats.

Treatment with BVA at the ST36 acupoint in normal rats did not induce the clinical signs. Pretreatment with BVA suppressed demyelination, glial activation, expression of cytokines [interferon (IFN)-γ, IL-17, IL-17A, tumor necrosis factor-alpha (TNF-α), and IL-1β], chemokines [RANTES, monocyte chemotactic protein-1 (MCP-1), and macrophage inflammatory protein (MIP)-1α], and inducible nitric oxide synthase (iNOS), and activation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB (p65 and phospho-IκBα) signaling pathways in the spinal cord of acute EAE rats.

Pretreatment with BVA decreased the number of CD4+, CD4+/IFN-γ+, and CD4+/IL-17+ T cells, but increased the number of CD4+/Foxp3+ T cells in the spinal cord and lymph nodes of acute EAE rats. Treatment with BVA at six placebo acupoints (SP9, GB39, and four non-acupoints) did not have a positive effect in acute EAE rats.

Interestingly, onset and posttreatment with BVA at the ST36 acupoint markedly attenuated neurological impairment in myelin oligodendrocyte glycoprotein (MOG)35-55-induced chronic EAE mice compared to treatment with BVA at six placebo acupoints. Our findings strongly suggest that treatment with BVA with ST36 acupoint could delay or attenuate the development and progression of EAE by upregulating regulatory T cells and suppressing T-helper (Th) 17 and Th1 responses.

These results warrant further investigation of BVA as a treatment for autoimmune disorders of the central nervous system.

Wednesday, January 14, 2015

Honey and Pollen Pose Little Threat Due to Lethality of Bees

Organophosphorus insecticides in honey, pollen and bees (Apis mellifera L.) and their potential hazard to bee colonies in Egypt
Ecotoxicol Environ Saf, 2015 Jan 6;114C:1-8
There is no clear single factor to date that explains colony loss in bees, but one factor proposed is the wide-spread application of agrochemicals. Concentrations of 14 organophosphorous insecticides (OPs) in honey bees (Apis mellifera) and hive matrices (honey and pollen) were measured to assess their hazard to honey bees.
Samples were collected during spring and summer of 2013, from 5 provinces in the middle delta of Egypt. LC/MS-MS was used to identify and quantify individual OPs by use of a modified Quick Easy Cheap Effective Rugged Safe (QuEChERS) method. Pesticides were detected more frequently in samples collected during summer. Pollen contained the greatest concentrations of OPs. Profenofos, chlorpyrifos, malation and diazinon were the most frequently detected OPs. In contrast, ethoprop, phorate, coumaphos and chlorpyrifos-oxon were not detected. A toxic units approach, with lethality as the endpoint was used in an additive model to assess the cumulative potential for adverse effects posed by OPs.
Hazard quotients (HQs) in honey and pollen ranged from 0.01-0.05 during spring and from 0.02-0.08 during summer, respectively. HQs based on lethality due to direct exposure of adult worker bees to OPs during spring and summer ranged from 0.04 to 0.1 for best and worst case respectively. It is concluded that direct exposure and/or dietary exposure to OPs in honey and pollen pose little threat due to lethality of bees in Egypt.

Tuesday, January 13, 2015

March Apitherapy Course in North Carolina

Learn more about Apitherapy for your health and beauty by enrolling in our Apitherapy Course that will be taught in the Lenoir-Rhyne University, Center for Graduate Studies, Asheville, NC.
Within a couple weeks before the class, you will receive a syllabus with information about each section of the course. Your instructors are Lady Spirit Moon, Certified Apitherapist, Master Herbalist, Nutrition Consultant, and Certified Beekeeper; and Dr. Norul Badriah Hassan, pharmacologist from the University of Malaysia, Medical Sciences, and beekeeper.

You will learn how to use all the products from the hive by creating your own formulas for health and beauty. There will also be a demonstration of micro and full bee stings.

The course starts Friday, March 20, 6-9pm; Saturday, March 21, 9 am – 5 pm with a catered lunch; and Sunday, March 22, 9 am-12 am.

Monday, January 12, 2015

Could honeybees help with human hair loss?

Charlotte Observer, 1/11/2015

A substance from honeybee hives might contain clues for developing a potential new therapy for human baldness: a material called propolis that encouraged hair growth in mice.

Propolis is a resinlike material that honeybees use to seal small gaps in their hives. It works as a physical barrier – but also contains active compounds that fight fungal and bacterial invasions. People from ancient times had noticed propolis’ special properties and used it to treat tumors, inflammation and wounds. Research has also shown that the substance promotes the growth of certain cells involved in hair growth, though no one had yet tested whether that in turn would result in new locks...