Friday, May 20, 2022

Bee Bread is Probiotic, Has Multiple Health Benefits

Biotechnological Processes Simulating the Natural Fermentation Process of Bee Bread and Therapeutic Properties-An Overview

Front Nutr. 2022 Apr 27

Recent signs of progress in functional foods and nutraceuticals highlighted the favorable impact of bioactive molecules on human health and longevity. As an outcome of the fermentation process, an increasing interest is developed in bee products.

Bee bread (BB) is a different product intended for humans and bees, resulting from bee pollen's lactic fermentation in the honeycombs, abundant in polyphenols, nutrients (vitamins and proteins), fatty acids, and minerals. BB conservation is correlated to bacteria metabolites, mainly created by Pseudomonas spp., Lactobacillus spp., and Saccharomyces spp., which give lactic acid bacteria the ability to outperform other microbial groups. Because of enzymatic transformations, the fermentation process increases the content of new compounds. After the fermentation process is finalized, the meaningful content of lactic acid and several metabolites prevent the damage caused by various pathogens that could influence the quality of BB.

Over the last few years, there has been an increase in bee pollen fermentation processes to unconventional dietary and functional supplements. The use of the chosen starters improves the bioavailability and digestibility of bioactive substances naturally found in bee pollen. As a consequence of enzymatic changes, the fermentation process enhances BB components and preserves them against loss of characteristics.

In this aspect, the present review describes the current biotechnological advancements in the development of BB rich in beneficial components derived from bee pollen fermentation and its use as a food supplement and probiotic product with increased shelf life and multiple health benefits.

Saturday, April 30, 2022

Propolis Supplementation Beneficial for Patients with Irritable Bowel Syndrome

HCPLive

New research shows propolis could be a useful supplement to help reduce the severity of irritable bowel syndrome (IBS) symptoms.

A team, led by Mahsa Miryan, Student Research Committee, Tabriz University of Medical Sciences, assessed the efficacy of propolis supplementation on the severity of IBS symptoms.

There is now evidence that propolis can modulate gastrointestinal function for patients with IBS.

“Emerging evidence has shown an important role of the modulating GI immune system and gut microbiota using prebiotic and/or probiotic supplements in ameliorating the symptoms of IBS, which has been beneficial for many patients,” the authors wrote. “Dietary polyphenols and their secondary metabolites also have a crucial role in maintaining the balance of the GI microbiome by altering bacterial metabolites that can raise mucin gene expression, resulting in an increase in the thickness of the GI mucosal layer and also reduction in GI inflammation.”...

Thursday, April 28, 2022

Propolis Helps Treat Wounds, Burns, Acne, Herpes


Deccan Herald

...Many systems of medicine use propolis to treat cold-like symptoms, wounds, burns, acne, herpes and other skin conditions. Studies have shown that propolis works against bacteria, viruses, protozoans and fungi, and has antioxidant and anaesthetic prop...




Friday, April 01, 2022

Ukrainian Bees Kill 3 Russian Invaders


DAILY STAR

A freak bee attack in Ukraine has killed three Russian soldiers and left 25 more in hospital needing treatment.

According to Ukrainian news site Kherson News, a bike of black and yellow mini beasts have joined the fight in defending the country from invading forces.

Monday, March 28, 2022

March 30th is World Apitherapy Day - A Series of Lectures by Leading Experts






EN HONOR A NACIMIENTO DEL DR. FILIP TERC, PADRE DE LA APITERAPIA MODERNA.


When/Cuándo: March 30, 2022 (Wednesday), 3 pm Austria time / miércoles 30 de marzo de 2022, 3 pm hora de Austria

5-10 minute presentation in English PowerPoint and any language audio / ponencias orales de 5-10 minutos en cualquier idioma con acompañamiento de PowerPoint en inglés.

The technical details of our meeting:

Detalles técnicos de la reunión:

Start: March 30 (Wednesday) at 15 h. Vienna (Austria) time (6 am in Vancouver, 2 pm in United Kingdom, 9 am in Miami and New York).

End: around 19 h.

The link to the ZOOM platform will be: https://us02web.zoom.us/j/7677675492 Password: 1234

The link to Facebook, for the live transmission will be: https://www.facebook.com/drstangaciu

ESPAÑOL:

Comienzo el 30 de marzo (miércoles) a las 3 pm hora de Austria (10 am en Argentina y Chile, 8 am en Ecuador, 3 pm en España, 7 am en México, 9 am en Miami y Nueva York).

El enlace a la plataforma ZOOM será: https://us02web.zoom.us/j/7677675492 Password: 1234

El enlace a Facebook para la trasmisión en vivo será: https://www.facebook.com/drstangaciu

Thursday, March 24, 2022

Everything to Know About Apitherapy


Medical News Today

Apitherapy is an alternative therapy that uses products made by honeybees for medicinal purposes. These products include honey, beeswax, royal jelly, pollen, propolis, and bee venom. Apitherapists may use a combination of these products, depending on the condition they are treating...

Thursday, March 10, 2022

Video: How Bee Venom May Help Cure Cancer


Researchers from Perth's Harry Perkins Institute of Medical Research have discovered something interesting about bee venom.

WATCH THE VIDEO.

Monday, March 07, 2022

Upcoming Apitherapy Events Worldwide




Beehive Air Therapy Conference, in Spanish

March 19-20

For more details write an email to: DrStangaciu@Gmail.com

***

Beehive Air Therapy Conference, in Romanian

April 2-3

For more details write an email to: DrStangaciu@Gmail.com

***

Intensive Apitherapy Courses in Iran

April 9-13 and April 16-21
For more details write an email to: DrStangaciu@Gmail.com

***

German Apitherapy Workshops

April 24-30

***

International Conference on Propolis

May 5-7
***

First International Conference on Api-Microbiology

May 28-29

For more details write an email to: DrStangaciu@Gmail.com
***

First Api-Pediatry Conference in Arabic

June 29-30

For more details write an email to: DrStangaciu@Gmail.com and Prof. Mamdouh Abdelrhman mamdouh.abdelrhman@gmail.com

Monday, January 24, 2022

Azerbaijan Propolis May Help Treat Moderate-Severe Depression


Propolis add-on therapy alleviates depressive symptoms; A randomized placebo-controlled clinical trial


Phytother Res. 2022 Jan 24

Almost half of the treatments with common antidepressants are failed or result in a relapse of symptoms after cessation. Moreover, the antidepressants side effects rationalize the use of complementary medicine as an adjunctive therapy.

This study aimed to evaluate the efficacy and safety of propolis in complementary therapy of depressive disorder. Chromatography technics were used to detect propolis components. A double-blind, randomized, placebo-controlled trial was designed, and 54 participants were randomly assigned to receive either propolis or Placebo for 6 weeks.

Treatment was defined as a decrease in 17-item Hamilton Depression Scale (HAMD-17) and Beck depression inventory (BDI). On D42, there was a significant reduction in HAMD score in the propolis group compared with the placebo group (p < .0001). HAMD score significantly decreased in the propolis group from 20.92 ± 3.77 on D0 to 10.03 ± 5.55 on D42, and BDI score was improved from 29.25 ± 3.06 on D0 to 14.17 ± 4.86 on D42.

Our findings confirmed that complementary treatment of propolis with SSRIs could safely attenuate symptoms of moderate-severe MDD. These antidepressant effects might result from the rich phenolic acids and flavonoids content of Azerbaijan propolis.

Thursday, January 20, 2022

When will we see bee therapy in Australia?


As you know this week, John has had quite the fantasy with bees and he kept the ball rolling by talking to President of Australian Apitherapy Bridgett Goodwin.

Apitherapy is a branch of medicine alternative medicine that uses honey bee products.

Australia is yet to introduce bee therapy, but Bridgett states there are “many benefits”.

Friday, January 14, 2022

Research: Bee Pollen is a Source of Antioxidants and Antimicrobials


Screening of Plant Pollen Sources, Polyphenolic Compounds, Fatty Acids and Antioxidant/Antimicrobial Activity from Bee Pollen

Molecules 2022, 27(1), 117

In this study, the botanical origin, total flavonoid and phenolic content, antioxidant activity, phenolic profile and fatty acid composition of mixed bee pollen loads collected in Bayburt, Turkey, were determined.

In addition to these assays, antibacterial activity of bee-collected pollen extract (BCPE) against a variety of food-borne pathogenic bacteria was determined in vitro. Pollen loads were classified into five botanical families based on their color: Asteraceae, Fabaceae, Campanulaceae, Cistaceae and Rosaceae.

Total flavonoid, total phenolic, CUPRAC and CERAC concentrations were 173.52 mg GAE/g, 79.21 mg QE/g, 85.59 mg Trolox/g and 118.13 mg Trolox/g, respectively. Twenty-three phenolic compounds were scanned in bee pollen extract by LC-MS/MS, with rutin being the most abundant. Cis-4,7,10,13,16,19 docosahexaenoic acid was the predominant fatty acid, followed by cis-11-eicosenoic acid, palmitic acid, and alfa linolenic acid.

In addition, the agar well diffusion (AWD) and micro-broth dilution methods were used to determine of the antibacterial activity of the BCPE sample. MIC values were observed to vary between 2.5–5 mg/mL for Gram-positive bacteria and 5–10 mg/mL for Gram-negative bacteria.

These findings indicate that bee pollen could be a potential source of antioxidants and antimicrobials.

Wednesday, January 05, 2022

Propolis and Honey Better Than Acyclovir for Treating Cold Sores and Genital Herpes


Effect of honey and propolis, compared to acyclovir, against Herpes Simplex Virus (HSV)-induced lesions: A systematic review and meta-analysis


J Ethnopharmacol. 2021 Dec 26;287:114939

Ethnopharmacological relevance: Apitherapy is a branch of traditional medicine that uses bee products to manage numerous diseases. In this context, the antiherpetic effect of these bee products has been demonstrated in some studies with some controversial results.

Aim of the study: Thus, we conducted a systematic review and meta-analysis to compare the effectiveness of honey and propolis with acyclovir, the reference drug, in the treatment of cold sores and genital herpes.

Materials and methods: The selection of eligible studies was conducted through the search in Pubmed/MEDLINE, Scopus, Cochrane Library, LILACS, and Electronic Scientific Library.

Results: The search yielded 147 articles, of which nine were considered eligible for analysis. The analysis of these studies showed that the healing property of propolis is superior to that obtained for acyclovir (95% CI: 2.70 to 8.25; p = 0.0001). Furthermore, honey also presented a better healing effect than acyclovir against Herpes simplex virus-induced wounds (95% CI: 3.58 to -0.19; p = 0.03), inducing complete re-epithelization of herpetic lesions after 8 days, while for acyclovir, the healing time average was 9 days. It also provoked a similar reduction of pain caused by herpetic compared to acyclovir (95% CI: 2.27 to -0.42; p = 0.18).

Conclusions: Overall, these results confirm the use of honey and propolis as potent antiherpetic agents.

Tuesday, January 04, 2022

Report on the Health Benefits of Bee Products in Boosting Immunity; Treating Cancer, Diabetes, High Cholesterol, High Blood Pressure, Allergies


Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds

J Agric Food Chem. 2022 Jan 2.

Beside honey, honeybees (Apis mellifera L.) are able to produce many byproducts, including bee pollen, propolis, bee bread, royal jelly, and beeswax. Even if the medicinal properties of these byproducts have been recognized for thousands of years by the ancient civilizations, in the modern era, they have a limited use, essentially as nutritional supplements or health products. However, these natural products are excellent sources of bioactive compounds, macro- and micronutrients, that, in a synergistic way, confer multiple biological activities to these byproducts, such as, for example, antimicrobial, antioxidant, and anti-inflammatory properties.

This work aims to update the chemical and phytochemical composition of bee pollen, propolis, bee bread, royal jelly, and beeswax and to summarize the main effects exerted by these byproducts on human health, from the anticancer and immune-modulatory activities to the antidiabetic, hypolipidemic, hypotensive, and anti-allergic properties.

Wednesday, December 22, 2021

Propolis Induces Programmed Death in Human Bladder Cancer Cells


Apoptotic and Anti-angiogenic effects of propolis against human bladder cancer: Molecular docking and in vitro screening


Biomarkers. 2021 Dec 20;1-13

Introduction; Bladder cancer is still of unknown initiation and progression, it is difficult to treat the patient once bladder cancer have a distant metastasis.

Materials and Methods: In the present study, propolis extract was evaluated against bladder cancer cells (T24). Two independent pathways were investigated, apoptosis and angiogenesis, Bax, Bcl-2, P53, and caspase-3 for apoptosis, vascular endothelial growth factor receptor and protein kinase A as angiogenesis potential targets.

Objectives: Molecular docking studies will be conducted for the major known constituents of Egyptian propolis into apoptotic and angiogenic protein targets, to give better insights to the possible binding mode and interactions and investigate the ability of propolis constituents to target both apoptotic and angiogenic pathways.

Results: Propolis showed anti proliferative activity against T24 cancer cell line, IC50 value was 6.36 µg/ml. Also significant effects of propolis on Bax, Bcl-2, P53, and caspase-3 were observed. Discussion: These obtained results proved the ability of propolis to induce cell death. Also it has revealed noticeable effects on protein kinase A and vascular endothelial growth factor receptor.

Conclusion: The obtained results can encourage us to say that propolis extract can induce a programmed cell death in human bladder cancer cells, and also affect angiogenesis.