Monday, February 07, 2011
Journal of Nanobiotechnology, 4 February 2011
The use of natural products based on aqueous extract of propolis and lycopene in the skin's protective mechanisms against UVA radiation was evaluated by means of experimental acute inflammation on rat paw edema.
The purpose of the study is the evaluation of the inoffensiveness of the propolis lycopene system, by evaluating skin level changes and anti-inflammatory action.
The regenerative and protective effect of the aqueous propolis and lycopene extract is due to the fact that it is rich in biologically active substances: tocopherols, flavonoids, amino acids, polyunsaturated fatty acids, the chlorophyll pigment, which are substances with a strong antioxidant action, that contribute to the modification of oxidative stress, especially by reducing the prooxidant processes and enhancing the antioxidant ones.
They participate in the synthesis of the prostaglandins and phospholipids composing the cell membranes and thus enhance the protection mechanisms in the skin. The formulated systems offered a sustained release of the drug, in vitro, for a time period of eight hours. The formulations that were prepared did not have a deteriorating effect on the tissues. They proved a better therapeutic efficiency compared to the standard suspension, because they were superior in improving the monitorized parameters for a longer period of time (24 hours).
The preliminary examination of the tissues shows that the formulations did not produce irritations. The local application of the aqueous propolis and lycopene extract nanoemulsion has a high potential both regarding its efficiency (the analgesic effect) and therapeutic safety. This research demonstrates the fact that the aqueous propolis and lycopene extract nanoemulsions, which are preparations that contain active substances, can confer better therapeutic effects than those of the conventional formulations, because of the local controlled-release of the dozed form, in a longer period of time, which may lead to an improvement of its efficiency and to the skin accepting it more easily, meaning a better compliance.
The information gathered in the present research suggests that the administration of aqueous propolis and lycopene extract nanoemulsion be safe and inoffensive. The preparation can be recommended for further preclinical studies. Lycopene embedded in aqueous propolis extract can be used in pharmaceuticals (targeted medical therapy).