Journal of Applied Polymer Science, Early View
In this study, nanofiber meshes were produced from aqueous
mixtures of poly(vinyl alcohol) (PVA) and honey via electrospinning. The
Electrospinning process was performed at different PVAs to honey ratios (100/0,
90/10, 80/20, 70/30, and 60/40).
Dexamethasone sodium phosphate was selected as an
anti-inflammatory drug and incorporated in the electrospinning solutions. Its
release behavior was determined. Uniform and smooth nanofibers were formed,
independent of the honey content. In case honey content increased up to 40%,
some spindle-like beads on the fibers were observed. The diameter of
electrospun fibers decreased as the ratio of honey increased. The release
characteristics of the model drug from both the PVA and PVA/honey (80/20)
nanofibrous mats were studied and statistical analysis was performed.
All electrospun fibers exhibited a large initial burst
release at a short time after incubation. The release profile was similar for
both PVA and PVA/honey (80/20) drug-loaded nanofibers.
This study shows that an anti-inflammatory drug can be
released during the initial stages and honey can be used as a natural
antibiotic to improve the wound dressing efficiency and increase the healing
rate.
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