Caffeic Acid Phenetyl Ester Accelerates Cutaneous Wound Healing in a Rat Model and Decreases Oxidative Stress
Clinical and Experimental Dermatology, Volume 32 Issue 6 Page 709-715, November 2007
Background. Cutaneous injury causes a depression in antioxidant status, as reactive oxygen species (ROS) are produced in response to injury.
Aim. To determine the effects of caffeic acid phenethyl ester (CAPE), an antioxidant and anti-inflammatory agent, on wound healing in rats…
Results. Wound tissues showed a significant increase in glutathione and nitric oxide levels, and a significant decrease in malondialdehyde levels and superoxide dismutase levels in the CAPE group compared with the control group. Histopathology of the wound tissues displayed rapid epithelium development in the CAPE group compared with the control group.
Conclusion. This study has demonstrated that CAPE partly accelerates full-thickness wound healing by its antioxidant and ROS-scavenging capabilities.