Duration-Dependent Hepatoprotective Effects of Propolis Extract Against Carbon Tetrachloride-Induced Acute Liver Damage IN Rats.
Advances in Therapy, 2007 Sep-Oct;24(5):1136-45
Propolis is a natural product produced by bees that was discovered through the study of traditional cures and knowledge of indigenous people throughout the world. It is rich in vitamins A, B, C, and E, and in amino acids, copper, iron, manganese, and zinc.
The investigators studied the duration-dependent hepatoprotective effects of propolis extract (200 mg/kg, orally) against carbon tetrachloride (CCl(4); 1.5 mL/kg, intraperitoneally)-induced liver damage in rats…
Propolis extract reversed alterations in all parameters when administered within 6, 12, and 24 h of toxicant exposure. Propolis therapy produced duration-dependent protection, with maximal protection achieved at 24 h after CCl(4) exposure. It is believed that propolis in its natural form has general pharmacologic value and marked hepatoprotective potential because of its composition of minerals, flavonoids, and phenolic compounds.