A Dipeptide YY Derived from Royal Jelly Proteins Inhibits Renin ActivityInt J Mol Med, 2008 Jun;21(6):677-81
Renin is the rate limiting enzyme in the renin-angiotensin (RA) system that regulates blood pressure and electrolyte balance.
In this study, we investigated the renin inhibitory effect of a royal jelly (RJ)-derived peptide. A dipeptide YY was isolated from the digested fraction of RJ proteins by proteases and was found to inhibit human renin activity.
The inhibition constant (Ki) of YY was estimated to be 10 muM when the Km was 0.16 muM using sheep angiotensinogen as the substrate. The peptide was observed to lower blood pressure in spontaneously hypertensive rats.
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