Propolis Blocks Growth of Tumor Blood Vessels

Propolis Suppresses Tumor Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells
Biosci Biotechnol Biochem, 2008 Sep 7.

We have reported that propolis suppresses tumor-induced angiogenesis in vivo and in vitro, but antiangiogenic mechanism of propolis at cellular level remains unclear. In this study, we observed that propolis not only inhibited tube formation but also induced apoptosis of endothelial cells. These results suggest that propolis exerts its antiangiogenic effects at least in part through induction of apoptosis.