Potential Antidiabetic and Hypolipidemic Effects of Propolis Extract in Streptozotocin-Induced Diabetic RatsPakistan Journal of Pharmaceutical Sciences, Vol. 22, No. 2, April 2009
Free radicals have been implicated in the pathogenesis of diabetes mellitus leading to various complications including atherosclerosis. Propolis was reported to have oxygen radical scavenging activity. The present study was designed to investigate the possible antidiabetic, hypolipidemic and antioxidant effects of ethanolic extract of propolis (EEP)…
Oral administration of propolis extract in doses of 100,200 & 300 mg/kg bwt improved the body and kidney weights, serum glucose, lipid profile, MDA and renal function tests. Renal GSH, SOD and CAT were significantly increased while MDA was markedly reduced. These results may suggest a strong antioxidant effect of propolis which can ameliorate oxidative stress and delay the occurrence of diabetic nephropathy in diabetes mellitus…
In conclusion, EEP offers a promising therapeutic value in prevention of diabetes and dyslipidemic profile. These effects could be mainly attributed to its antioxidant properties as shown by significant quenching impact on the extent of lipid peroxidation along with, enhancement of antioxidant defense systems in pancreatic tissue. Further studies will be needed in future to determine the main active ingredient having the beneficial antidiabetic, hypolipidemic and antioxidant effects.
1 comment:
My father is is 70+ years of age. He is diabetic and normally controls with medication and diet. A few years ago he was attached by killer Bee's and stung over 500 times. He survived through immediate medical attention at the local ER. The extrodinary thing that came from this is that for approx next 6 months his blood sugar level stayed normal without any medication or diet. We beleive there is some relation to the Bee Venom.
David Buckley
davidbuc@gmail.com
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